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• W2507430173 endingPage "87" @default.
• W2507430173 startingPage "71" @default.
• W2507430173 abstract "Tyrosine kinase inhibitors (TKIs) targeting the BCR-ABL1 oncoprotein represent an outstanding progress in chronic myeloid leukemia (CML), and long-term survival without transformation to blast phase CML has become a reality. However, the majority of patients need to be treated during their entire lifespan; thus, the outcome does not solely depend on treatment efficacy but also on how well therapy is tolerated. TKIs have shown an overall favorable safety profile in clinical trials. Although many patients may encounter drug-related adverse events, these usually occur early after treatment initiation, are mild to moderate in intensity, and resolve spontaneously or are easily controlled with adequate supportive care. Whenever treatment interruption is necessary, reexposition to the same TKI or switch to an alternative TKI is successful in the majority of the cases. However, long-term tolerability and safety issues have not been fully elucidated at present, especially for new-generation TKIs. Recent evidence has emerged that these new agents may sometimes impinge on vital organs such as the heart and lung in an irreversible fashion especially when comorbidities are present; thus, decision regarding of which TKI should be used must take into account disease-related, TKI-related, and patient-related variables. The purpose of this article is to provide an up-to-date review of common adverse events associated with TKIs and how these events may be optimally managed." @default.
• W2507430173 created "2016-09-16" @default.
• W2507430173 creator A5055797334 @default.
• W2507430173 date "2016-01-01" @default.
• W2507430173 modified "2023-09-25" @default.
• W2507430173 title "Management of Adverse Events Associated with ATP-Competitive BCR-ABL1 Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia" @default.
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• W2507430173 doi "https://doi.org/10.1007/978-3-319-33198-0_5" @default.
• W2507430173 hasPublicationYear "2016" @default.
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