Matches in SemOpenAlex for { <https://semopenalex.org/work/W2507551170> ?p ?o ?g. }
- W2507551170 endingPage "34" @default.
- W2507551170 startingPage "25" @default.
- W2507551170 abstract "Toll-like receptors (TLRs) are central players in the innate immune system in response to a wide range of pathogen infection. Among various TLRs, TLR4 plays a key role in recognition of bacterial lipopolysaccharides (LPS). In the present study, we identified and characterized a novel TLR4 homologue (maTLR4b) in blunt snout bream (Megalobrama amblycephala) which was significantly distinct from previously reported M. amblycephala TLR4 (tentatively named maTLR4a). The results showed that the complete cDNA sequence of maTLR4b was 3261 bp with an open reading frame encoding a polypeptide of 820 amino acids, and that its genomic sequence was 3793 bp, which had 3 exons. Structurally, the deduced maTLR4b protein showed a typical TLR domain architecture, including a signal peptide, eight leucine-rich repeats (LRRs) in the extracellular region, a transmembrane domain, and a Toll-Interleukin 1 receptor (TIR) domain in the cytoplasmic region. Phylogenetic analysis revealed that all TLR4s from teleost fish formed a monophyletic clade. Both maTLR4a and maTLR4b were divided into two distinct branches, and showed the highest level of similarity with the grass carp TLR4.2 and TLR4.4 homologue, respectively. MaTLR4b was constitutively expressed in all healthy tissues tested although at different levels. After LPS stimulation, the expression levels were significantly up-regulated in spleen, and peaked at 4 h between maTLR4a and maTLR4b, but with a distinct and complementary expression patterns. Taken together, these results suggested that maTLR4b is indeed a functional homologue of TLR4 in other species, which may play vital role in innate immune." @default.
- W2507551170 created "2016-09-16" @default.
- W2507551170 creator A5004854548 @default.
- W2507551170 creator A5021232560 @default.
- W2507551170 creator A5033195034 @default.
- W2507551170 creator A5046072624 @default.
- W2507551170 creator A5052272892 @default.
- W2507551170 creator A5052383678 @default.
- W2507551170 creator A5060214273 @default.
- W2507551170 creator A5065821874 @default.
- W2507551170 creator A5074074463 @default.
- W2507551170 creator A5083858884 @default.
- W2507551170 date "2016-10-01" @default.
- W2507551170 modified "2023-10-10" @default.
- W2507551170 title "Identification and characterization of a novel Toll-like receptor 4 homologue in blunt snout bream, Megalobrama amblycephala" @default.
- W2507551170 cites W1481839642 @default.
- W2507551170 cites W1519754349 @default.
- W2507551170 cites W1966006200 @default.
- W2507551170 cites W1967696649 @default.
- W2507551170 cites W1968693613 @default.
- W2507551170 cites W1970836984 @default.
- W2507551170 cites W1971455275 @default.
- W2507551170 cites W1976300852 @default.
- W2507551170 cites W1977698433 @default.
- W2507551170 cites W1979759393 @default.
- W2507551170 cites W2001256354 @default.
- W2507551170 cites W2004622806 @default.
- W2507551170 cites W2004773897 @default.
- W2507551170 cites W2012795602 @default.
- W2507551170 cites W2025370517 @default.
- W2507551170 cites W2033023829 @default.
- W2507551170 cites W2033605140 @default.
- W2507551170 cites W2057002887 @default.
- W2507551170 cites W2061100655 @default.
- W2507551170 cites W2065319257 @default.
- W2507551170 cites W2070841084 @default.
- W2507551170 cites W2080532845 @default.
- W2507551170 cites W2081110616 @default.
- W2507551170 cites W2082476225 @default.
- W2507551170 cites W2087368694 @default.
- W2507551170 cites W2091398245 @default.
- W2507551170 cites W2094201044 @default.
- W2507551170 cites W2094505564 @default.
- W2507551170 cites W2095886784 @default.
- W2507551170 cites W2097098907 @default.
- W2507551170 cites W2106882534 @default.
- W2507551170 cites W2107277218 @default.
- W2507551170 cites W2109491705 @default.
- W2507551170 cites W2114637517 @default.
- W2507551170 cites W2115185894 @default.
- W2507551170 cites W2129319296 @default.
- W2507551170 cites W2139319766 @default.
- W2507551170 cites W2143135577 @default.
- W2507551170 cites W2152207030 @default.
- W2507551170 cites W2323625036 @default.
- W2507551170 cites W635454128 @default.
- W2507551170 doi "https://doi.org/10.1016/j.fsi.2016.08.015" @default.
- W2507551170 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27514781" @default.
- W2507551170 hasPublicationYear "2016" @default.
- W2507551170 type Work @default.
- W2507551170 sameAs 2507551170 @default.
- W2507551170 citedByCount "10" @default.
- W2507551170 countsByYear W25075511702017 @default.
- W2507551170 countsByYear W25075511702018 @default.
- W2507551170 countsByYear W25075511702020 @default.
- W2507551170 countsByYear W25075511702022 @default.
- W2507551170 countsByYear W25075511702023 @default.
- W2507551170 crossrefType "journal-article" @default.
- W2507551170 hasAuthorship W2507551170A5004854548 @default.
- W2507551170 hasAuthorship W2507551170A5021232560 @default.
- W2507551170 hasAuthorship W2507551170A5033195034 @default.
- W2507551170 hasAuthorship W2507551170A5046072624 @default.
- W2507551170 hasAuthorship W2507551170A5052272892 @default.
- W2507551170 hasAuthorship W2507551170A5052383678 @default.
- W2507551170 hasAuthorship W2507551170A5060214273 @default.
- W2507551170 hasAuthorship W2507551170A5065821874 @default.
- W2507551170 hasAuthorship W2507551170A5074074463 @default.
- W2507551170 hasAuthorship W2507551170A5083858884 @default.
- W2507551170 hasConcept C104317684 @default.
- W2507551170 hasConcept C10858879 @default.
- W2507551170 hasConcept C118892022 @default.
- W2507551170 hasConcept C136449434 @default.
- W2507551170 hasConcept C153911025 @default.
- W2507551170 hasConcept C167625842 @default.
- W2507551170 hasConcept C170493617 @default.
- W2507551170 hasConcept C2776070231 @default.
- W2507551170 hasConcept C2776709828 @default.
- W2507551170 hasConcept C2778130612 @default.
- W2507551170 hasConcept C47289529 @default.
- W2507551170 hasConcept C54355233 @default.
- W2507551170 hasConcept C86803240 @default.
- W2507551170 hasConceptScore W2507551170C104317684 @default.
- W2507551170 hasConceptScore W2507551170C10858879 @default.
- W2507551170 hasConceptScore W2507551170C118892022 @default.
- W2507551170 hasConceptScore W2507551170C136449434 @default.
- W2507551170 hasConceptScore W2507551170C153911025 @default.
- W2507551170 hasConceptScore W2507551170C167625842 @default.
- W2507551170 hasConceptScore W2507551170C170493617 @default.