Matches in SemOpenAlex for { <https://semopenalex.org/work/W2507562897> ?p ?o ?g. }
- W2507562897 abstract "It has been observed that the efficacy of dipeptidyl peptidase-4 (DPP-4) inhibitors as compared to the placebo groups in some clinical trials conducted in China is weaker than that in trials conducted outside China, leading to the suspicion that this may be caused by differential Glycosylated Hemoglobin (HbA1c) response in the placebo arm of DPP-4 inhibitor clinical trials conducted in China compared to other countries. We searched published articles and other documents related to phase III placebo-control trials of DPP-4 inhibitors in Type 2 diabetes mellitus (T2DM). We included studies from different countries and compared those conducted in China to those conducted in other countries. Meta-regression analysis was used to analyze the HbA1c response in the placebo arms. A total of 66 studies met the inclusion criteria and 10 were conducted within China. There were a total of 8303 participants (mean age 56, male 57 %) in placebo groups. The pooled change in HbA1c for the placebo groups of 10 trials conducted in patients with T2DM in China was 0.26 % (95 % CI [-0.36 %, -0.16 %], p-value < 0.001), compared to 0.015 % (95 % CI [-0.05 %, 0.08 %], p-value is 0.637) for 56 trials conducted outside of China. The difference of placebo effect between trials conducted in and outside China is -0.273 % (95 % CI [-0.42 %, -0.13 %], p-value is less than 0.001) while after excluding trials conducted in Japan, the difference is -0.203 % (95 % CI [-0.35 %, -0.06 %], p-value is 0.005). They are both statistically significant. The meta-analysis in the article demonstrates that there is statistically significant difference in the HbA1c response in the placebo arm of DPP-4 inhibitor clinical trials conducted in China compared to other countries. This differential HbA1c response in the placebo arm should be taken into consideration by both experimenters and medical decision makers when future DPP-4 studies are conducted in China." @default.
- W2507562897 created "2016-09-16" @default.
- W2507562897 creator A5013542379 @default.
- W2507562897 creator A5026144038 @default.
- W2507562897 creator A5033790908 @default.
- W2507562897 creator A5063687516 @default.
- W2507562897 creator A5084406173 @default.
- W2507562897 creator A5084703143 @default.
- W2507562897 date "2016-09-07" @default.
- W2507562897 modified "2023-10-10" @default.
- W2507562897 title "Differential HbA1c response in the placebo arm of DPP-4 inhibitor clinical trials conducted in China compared to other countries: a systematic review and meta-analysis" @default.
- W2507562897 cites W1480729244 @default.
- W2507562897 cites W1546635462 @default.
- W2507562897 cites W1585447752 @default.
- W2507562897 cites W1703986290 @default.
- W2507562897 cites W1857972531 @default.
- W2507562897 cites W1967847357 @default.
- W2507562897 cites W1968350300 @default.
- W2507562897 cites W1969389642 @default.
- W2507562897 cites W1970406523 @default.
- W2507562897 cites W1972215659 @default.
- W2507562897 cites W1973383046 @default.
- W2507562897 cites W1977619586 @default.
- W2507562897 cites W1981024765 @default.
- W2507562897 cites W1986215651 @default.
- W2507562897 cites W1994832750 @default.
- W2507562897 cites W2005379446 @default.
- W2507562897 cites W2006925617 @default.
- W2507562897 cites W2016691199 @default.
- W2507562897 cites W2025791731 @default.
- W2507562897 cites W2027249582 @default.
- W2507562897 cites W2037029106 @default.
- W2507562897 cites W2038693293 @default.
- W2507562897 cites W2038915028 @default.
- W2507562897 cites W2038953694 @default.
- W2507562897 cites W2042160152 @default.
- W2507562897 cites W2043326088 @default.
- W2507562897 cites W2045063167 @default.
- W2507562897 cites W2045321591 @default.
- W2507562897 cites W2047353065 @default.
- W2507562897 cites W2049323977 @default.
- W2507562897 cites W2051462052 @default.
- W2507562897 cites W2059245135 @default.
- W2507562897 cites W2059431020 @default.
- W2507562897 cites W2061865937 @default.
- W2507562897 cites W2067579363 @default.
- W2507562897 cites W2074142099 @default.
- W2507562897 cites W2081947250 @default.
- W2507562897 cites W2083808413 @default.
- W2507562897 cites W2085862152 @default.
- W2507562897 cites W2090078712 @default.
- W2507562897 cites W2092918268 @default.
- W2507562897 cites W2092920113 @default.
- W2507562897 cites W2101246901 @default.
- W2507562897 cites W2103058881 @default.
- W2507562897 cites W2104053168 @default.
- W2507562897 cites W2107992917 @default.
- W2507562897 cites W2109911153 @default.
- W2507562897 cites W2115176755 @default.
- W2507562897 cites W2118701488 @default.
- W2507562897 cites W2121242002 @default.
- W2507562897 cites W2126930838 @default.
- W2507562897 cites W2128648250 @default.
- W2507562897 cites W2129578585 @default.
- W2507562897 cites W2133244310 @default.
- W2507562897 cites W2135804687 @default.
- W2507562897 cites W2138801798 @default.
- W2507562897 cites W2138983478 @default.
- W2507562897 cites W2139923324 @default.
- W2507562897 cites W2140480989 @default.
- W2507562897 cites W2141946042 @default.
- W2507562897 cites W2145335273 @default.
- W2507562897 cites W2146898936 @default.
- W2507562897 cites W2157823046 @default.
- W2507562897 cites W2158727328 @default.
- W2507562897 cites W2164282118 @default.
- W2507562897 cites W2165727615 @default.
- W2507562897 cites W2166173635 @default.
- W2507562897 cites W2167621077 @default.
- W2507562897 cites W2171512247 @default.
- W2507562897 cites W2181940024 @default.
- W2507562897 cites W2188407105 @default.
- W2507562897 cites W2325963726 @default.
- W2507562897 cites W3210417240 @default.
- W2507562897 cites W4378093237 @default.
- W2507562897 doi "https://doi.org/10.1186/s40360-016-0084-7" @default.
- W2507562897 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5013632" @default.
- W2507562897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27600598" @default.
- W2507562897 hasPublicationYear "2016" @default.
- W2507562897 type Work @default.
- W2507562897 sameAs 2507562897 @default.
- W2507562897 citedByCount "5" @default.
- W2507562897 countsByYear W25075628972018 @default.
- W2507562897 countsByYear W25075628972020 @default.
- W2507562897 countsByYear W25075628972023 @default.
- W2507562897 crossrefType "journal-article" @default.
- W2507562897 hasAuthorship W2507562897A5013542379 @default.
- W2507562897 hasAuthorship W2507562897A5026144038 @default.
- W2507562897 hasAuthorship W2507562897A5033790908 @default.
- W2507562897 hasAuthorship W2507562897A5063687516 @default.