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- W2507575989 abstract "This review article describes the role of neutrophils in mucosal injury and the resulting crypt abscesses characteristic of ulcerative colitis. We also review selected biomarkers for monitoring neutrophil presence and activity in the mucosa as well as their potential as therapeutic targets.We have collated and selectively reviewed data on the most prominent well-established and emerging neutrophil-related biomarkers and potential therapeutic targets (calprotectin, lactoferrin, CXCR1, CXCR2, MMP-9, NGAL, elafin, HNE, pANCAs, MPO, CD16, CD177, CD64, HNPs, SLPI and PTX3) in ulcerative colitis.Systemic and intestinal neutrophil activity increases substantially in active ulcerative colitis, driving tissue damage and extra-intestinal manifestations. Calprotectin is a robust neutrophil and disease biomarker, and a few neutrophil-related targets are being clinically explored as therapeutic targets.We propose that targeting neutrophils and their inflammatory mediators per se is an opportunity that should be explored to identify new effective medical therapies. The overall clinical goal for neutrophil-targeted therapy will be to modulate, but not completely silence, neutrophil activity, thereby abolishing the destructive inflammation with associated acute and chronic tissue damage without compromising host-defense." @default.
- W2507575989 created "2016-09-16" @default.
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- W2507575989 date "2016-09-27" @default.
- W2507575989 modified "2023-10-17" @default.
- W2507575989 title "Neutrophils in ulcerative colitis: a review of selected biomarkers and their potential therapeutic implications" @default.
- W2507575989 cites W1501778305 @default.
- W2507575989 cites W1562821701 @default.
- W2507575989 cites W1580622436 @default.
- W2507575989 cites W1678264379 @default.
- W2507575989 cites W1847993443 @default.
- W2507575989 cites W1924115225 @default.
- W2507575989 cites W1949927726 @default.
- W2507575989 cites W1967872091 @default.
- W2507575989 cites W1968062436 @default.
- W2507575989 cites W1974246098 @default.
- W2507575989 cites W1976188452 @default.
- W2507575989 cites W1977160855 @default.
- W2507575989 cites W1977775656 @default.
- W2507575989 cites W1977805207 @default.
- W2507575989 cites W1980242851 @default.
- W2507575989 cites W1982304490 @default.
- W2507575989 cites W1985220113 @default.
- W2507575989 cites W1987159173 @default.
- W2507575989 cites W1988019968 @default.
- W2507575989 cites W1989889358 @default.
- W2507575989 cites W1990852282 @default.
- W2507575989 cites W1991521290 @default.
- W2507575989 cites W1991688187 @default.
- W2507575989 cites W1992347215 @default.
- W2507575989 cites W1993753754 @default.
- W2507575989 cites W1997731852 @default.
- W2507575989 cites W1999413206 @default.
- W2507575989 cites W1999576842 @default.
- W2507575989 cites W2000073606 @default.
- W2507575989 cites W2002157461 @default.
- W2507575989 cites W2004638361 @default.
- W2507575989 cites W2008345543 @default.
- W2507575989 cites W2009672148 @default.
- W2507575989 cites W2012541226 @default.
- W2507575989 cites W2013971617 @default.
- W2507575989 cites W2023878955 @default.
- W2507575989 cites W2025549389 @default.
- W2507575989 cites W2029196664 @default.
- W2507575989 cites W2032380005 @default.
- W2507575989 cites W2033358607 @default.
- W2507575989 cites W2033753616 @default.
- W2507575989 cites W2034252508 @default.
- W2507575989 cites W2037542404 @default.
- W2507575989 cites W2039455576 @default.
- W2507575989 cites W2041191366 @default.
- W2507575989 cites W2042057041 @default.
- W2507575989 cites W2044947405 @default.
- W2507575989 cites W2046106520 @default.
- W2507575989 cites W2046234296 @default.
- W2507575989 cites W2046677507 @default.
- W2507575989 cites W2047061163 @default.
- W2507575989 cites W2048882304 @default.
- W2507575989 cites W2049224342 @default.
- W2507575989 cites W2050610603 @default.
- W2507575989 cites W2051144159 @default.
- W2507575989 cites W2051292920 @default.
- W2507575989 cites W2053043355 @default.
- W2507575989 cites W2054378007 @default.
- W2507575989 cites W2055284977 @default.
- W2507575989 cites W2057141381 @default.
- W2507575989 cites W2059466009 @default.
- W2507575989 cites W2060866852 @default.
- W2507575989 cites W2061837689 @default.
- W2507575989 cites W2061927074 @default.
- W2507575989 cites W2062859142 @default.
- W2507575989 cites W2065784891 @default.
- W2507575989 cites W2068244888 @default.
- W2507575989 cites W2069931076 @default.
- W2507575989 cites W2071030556 @default.
- W2507575989 cites W2071597446 @default.
- W2507575989 cites W2071970004 @default.
- W2507575989 cites W2072766425 @default.
- W2507575989 cites W2074312163 @default.
- W2507575989 cites W2074944880 @default.
- W2507575989 cites W2077187057 @default.
- W2507575989 cites W2081043785 @default.
- W2507575989 cites W2088329704 @default.
- W2507575989 cites W2088874765 @default.
- W2507575989 cites W2091592849 @default.
- W2507575989 cites W2092895549 @default.
- W2507575989 cites W2094436918 @default.
- W2507575989 cites W2098254123 @default.