FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2507601502> ?p ?o ?g. }

• W2507601502 endingPage "e0161096" @default.
• W2507601502 startingPage "e0161096" @default.
• W2507601502 abstract "Chromatin remodelling is essential for cardiac development. Interestingly, the role of histone chaperones has not been investigated in this regard. HIRA is a member of the HUCA (HIRA/UBN1/CABIN1/ASF1a) complex that deposits the variant histone H3.3 on chromatin independently of replication. Lack of HIRA has general effects on chromatin and gene expression dynamics in embryonic stem cells and mouse oocytes. Here we describe the conditional ablation of Hira in the cardiogenic mesoderm of mice. We observed surface oedema, ventricular and atrial septal defects and embryonic lethality. We identified dysregulation of a subset of cardiac genes, notably upregulation of troponins Tnni2 and Tnnt3, involved in cardiac contractility and decreased expression of Epha3, a gene necessary for the fusion of the muscular ventricular septum and the atrioventricular cushions. We found that HIRA binds GAGA rich DNA loci in the embryonic heart, and in particular a previously described enhancer of Tnni2/Tnnt3 (TTe) bound by the transcription factor NKX2.5. HIRA-dependent H3.3 enrichment was observed at the TTe in embryonic stem cells (ESC) differentiated toward cardiomyocytes in vitro. Thus, we show here that HIRA has locus-specific effects on gene expression and that histone chaperone activity is vital for normal heart development, impinging on pathways regulated by an established cardiac transcription factor." @default.
• W2507601502 created "2016-09-16" @default.
• W2507601502 creator A5006975414 @default.
• W2507601502 creator A5029919093 @default.
• W2507601502 creator A5032920346 @default.
• W2507601502 creator A5048715246 @default.
• W2507601502 creator A5056234717 @default.
• W2507601502 creator A5057285218 @default.
• W2507601502 creator A5058357613 @default.
• W2507601502 creator A5060218195 @default.
• W2507601502 creator A5082440058 @default.
• W2507601502 creator A5087843623 @default.
• W2507601502 date "2016-08-12" @default.
• W2507601502 modified "2023-10-17" @default.
• W2507601502 title "HIRA Is Required for Heart Development and Directly Regulates Tnni2 and Tnnt3" @default.
• W2507601502 cites W1520697307 @default.
• W2507601502 cites W1820593444 @default.
• W2507601502 cites W1964378643 @default.
• W2507601502 cites W1965767695 @default.
• W2507601502 cites W1967444593 @default.
• W2507601502 cites W1970916644 @default.
• W2507601502 cites W1979211289 @default.
• W2507601502 cites W1982160073 @default.
• W2507601502 cites W1987855481 @default.
• W2507601502 cites W1993913999 @default.
• W2507601502 cites W1994222671 @default.
• W2507601502 cites W1994995054 @default.
• W2507601502 cites W2009989504 @default.
• W2507601502 cites W2013799203 @default.
• W2507601502 cites W2026865013 @default.
• W2507601502 cites W2029151607 @default.
• W2507601502 cites W2035215912 @default.
• W2507601502 cites W2047575279 @default.
• W2507601502 cites W2052204674 @default.
• W2507601502 cites W2057516068 @default.
• W2507601502 cites W2064382418 @default.
• W2507601502 cites W2066236382 @default.
• W2507601502 cites W2075928340 @default.
• W2507601502 cites W2085315537 @default.
• W2507601502 cites W2096378879 @default.
• W2507601502 cites W2096725497 @default.
• W2507601502 cites W2099188975 @default.
• W2507601502 cites W2103978268 @default.
• W2507601502 cites W2108592161 @default.
• W2507601502 cites W2111452249 @default.
• W2507601502 cites W2133460513 @default.
• W2507601502 cites W2136623765 @default.
• W2507601502 cites W2141002059 @default.
• W2507601502 cites W2142958173 @default.
• W2507601502 cites W2146735843 @default.
• W2507601502 cites W2150438590 @default.
• W2507601502 cites W2158653767 @default.
• W2507601502 cites W2160358323 @default.
• W2507601502 cites W2169357646 @default.
• W2507601502 cites W2169367914 @default.
• W2507601502 cites W2171770969 @default.
• W2507601502 cites W417902414 @default.
• W2507601502 doi "https://doi.org/10.1371/journal.pone.0161096" @default.
• W2507601502 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4982693" @default.
• W2507601502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27518902" @default.
• W2507601502 hasPublicationYear "2016" @default.
• W2507601502 type Work @default.
• W2507601502 sameAs 2507601502 @default.
• W2507601502 citedByCount "25" @default.
• W2507601502 countsByYear W25076015022017 @default.
• W2507601502 countsByYear W25076015022018 @default.
• W2507601502 countsByYear W25076015022019 @default.
• W2507601502 countsByYear W25076015022020 @default.
• W2507601502 countsByYear W25076015022021 @default.
• W2507601502 countsByYear W25076015022022 @default.
• W2507601502 countsByYear W25076015022023 @default.
• W2507601502 crossrefType "journal-article" @default.
• W2507601502 hasAuthorship W2507601502A5006975414 @default.
• W2507601502 hasAuthorship W2507601502A5029919093 @default.
• W2507601502 hasAuthorship W2507601502A5032920346 @default.
• W2507601502 hasAuthorship W2507601502A5048715246 @default.
• W2507601502 hasAuthorship W2507601502A5056234717 @default.
• W2507601502 hasAuthorship W2507601502A5057285218 @default.
• W2507601502 hasAuthorship W2507601502A5058357613 @default.
• W2507601502 hasAuthorship W2507601502A5060218195 @default.
• W2507601502 hasAuthorship W2507601502A5082440058 @default.
• W2507601502 hasAuthorship W2507601502A5087843623 @default.
• W2507601502 hasBestOaLocation W25076015021 @default.
• W2507601502 hasConcept C104317684 @default.
• W2507601502 hasConcept C111936080 @default.
• W2507601502 hasConcept C116186050 @default.
• W2507601502 hasConcept C145103041 @default.
• W2507601502 hasConcept C51183755 @default.
• W2507601502 hasConcept C54355233 @default.
• W2507601502 hasConcept C62425271 @default.
• W2507601502 hasConcept C64927066 @default.
• W2507601502 hasConcept C6997183 @default.
• W2507601502 hasConcept C74581901 @default.
• W2507601502 hasConcept C8035138 @default.
• W2507601502 hasConcept C83482732 @default.
• W2507601502 hasConcept C83640560 @default.
• W2507601502 hasConcept C86339819 @default.
• W2507601502 hasConcept C86803240 @default.

• next