Matches in SemOpenAlex for { <https://semopenalex.org/work/W2507608410> ?p ?o ?g. }
- W2507608410 endingPage "1045" @default.
- W2507608410 startingPage "1037" @default.
- W2507608410 abstract "Detection of more than 1,000 different T-cell specificities in parallel facilitates identification of cancer and autoimmune antigens. Identification of the peptides recognized by individual T cells is important for understanding and treating immune-related diseases. Current cytometry-based approaches are limited to the simultaneous screening of 10–100 distinct T-cell specificities in one sample. Here we use peptide–major histocompatibility complex (MHC) multimers labeled with individual DNA barcodes to screen >1,000 peptide specificities in a single sample, and detect low-frequency CD8 T cells specific for virus- or cancer-restricted antigens. When analyzing T-cell recognition of shared melanoma antigens before and after adoptive cell therapy in melanoma patients, we observe a greater number of melanoma-specific T-cell populations compared with cytometry-based approaches. Furthermore, we detect neoepitope-specific T cells in tumor-infiltrating lymphocytes and peripheral blood from patients with non-small cell lung cancer. Barcode-labeled pMHC multimers enable the combination of functional T-cell analysis with large-scale epitope recognition profiling for the characterization of T-cell recognition in various diseases, including in small clinical samples." @default.
- W2507608410 created "2016-09-16" @default.
- W2507608410 creator A5003779074 @default.
- W2507608410 creator A5004154177 @default.
- W2507608410 creator A5004854900 @default.
- W2507608410 creator A5015690017 @default.
- W2507608410 creator A5016475369 @default.
- W2507608410 creator A5017744060 @default.
- W2507608410 creator A5021830443 @default.
- W2507608410 creator A5025825017 @default.
- W2507608410 creator A5033440492 @default.
- W2507608410 creator A5035783276 @default.
- W2507608410 creator A5039990981 @default.
- W2507608410 creator A5045265664 @default.
- W2507608410 creator A5051043977 @default.
- W2507608410 creator A5056525592 @default.
- W2507608410 creator A5057893015 @default.
- W2507608410 creator A5070724436 @default.
- W2507608410 creator A5073926805 @default.
- W2507608410 creator A5082386045 @default.
- W2507608410 date "2016-08-29" @default.
- W2507608410 modified "2023-10-17" @default.
- W2507608410 title "Large-scale detection of antigen-specific T cells using peptide-MHC-I multimers labeled with DNA barcodes" @default.
- W2507608410 cites W1496724330 @default.
- W2507608410 cites W1511171894 @default.
- W2507608410 cites W1540445127 @default.
- W2507608410 cites W1581592894 @default.
- W2507608410 cites W1599999513 @default.
- W2507608410 cites W1821172549 @default.
- W2507608410 cites W1821178503 @default.
- W2507608410 cites W1871621537 @default.
- W2507608410 cites W1929072836 @default.
- W2507608410 cites W1951988019 @default.
- W2507608410 cites W1968657935 @default.
- W2507608410 cites W1969475094 @default.
- W2507608410 cites W1976247253 @default.
- W2507608410 cites W1977281284 @default.
- W2507608410 cites W1978518799 @default.
- W2507608410 cites W1990395260 @default.
- W2507608410 cites W1993238707 @default.
- W2507608410 cites W1994048581 @default.
- W2507608410 cites W1994837401 @default.
- W2507608410 cites W1995138538 @default.
- W2507608410 cites W2013638194 @default.
- W2507608410 cites W2017672874 @default.
- W2507608410 cites W2020050960 @default.
- W2507608410 cites W2024626836 @default.
- W2507608410 cites W2031011895 @default.
- W2507608410 cites W2031970585 @default.
- W2507608410 cites W2041677964 @default.
- W2507608410 cites W2043071551 @default.
- W2507608410 cites W2046407551 @default.
- W2507608410 cites W2047269755 @default.
- W2507608410 cites W2049553585 @default.
- W2507608410 cites W2067069532 @default.
- W2507608410 cites W2069601112 @default.
- W2507608410 cites W2086737677 @default.
- W2507608410 cites W2091266578 @default.
- W2507608410 cites W2104885590 @default.
- W2507608410 cites W2106458784 @default.
- W2507608410 cites W2107018762 @default.
- W2507608410 cites W2114104545 @default.
- W2507608410 cites W2120508717 @default.
- W2507608410 cites W2135937351 @default.
- W2507608410 cites W2139517175 @default.
- W2507608410 cites W2142739377 @default.
- W2507608410 cites W2147401292 @default.
- W2507608410 cites W2150056019 @default.
- W2507608410 cites W2150575159 @default.
- W2507608410 cites W2157384708 @default.
- W2507608410 cites W2170551349 @default.
- W2507608410 cites W2291298003 @default.
- W2507608410 cites W2309691699 @default.
- W2507608410 cites W2560367415 @default.
- W2507608410 doi "https://doi.org/10.1038/nbt.3662" @default.
- W2507608410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27571370" @default.
- W2507608410 hasPublicationYear "2016" @default.
- W2507608410 type Work @default.
- W2507608410 sameAs 2507608410 @default.
- W2507608410 citedByCount "238" @default.
- W2507608410 countsByYear W25076084102017 @default.
- W2507608410 countsByYear W25076084102018 @default.
- W2507608410 countsByYear W25076084102019 @default.
- W2507608410 countsByYear W25076084102020 @default.
- W2507608410 countsByYear W25076084102021 @default.
- W2507608410 countsByYear W25076084102022 @default.
- W2507608410 countsByYear W25076084102023 @default.
- W2507608410 crossrefType "journal-article" @default.
- W2507608410 hasAuthorship W2507608410A5003779074 @default.
- W2507608410 hasAuthorship W2507608410A5004154177 @default.
- W2507608410 hasAuthorship W2507608410A5004854900 @default.
- W2507608410 hasAuthorship W2507608410A5015690017 @default.
- W2507608410 hasAuthorship W2507608410A5016475369 @default.
- W2507608410 hasAuthorship W2507608410A5017744060 @default.
- W2507608410 hasAuthorship W2507608410A5021830443 @default.
- W2507608410 hasAuthorship W2507608410A5025825017 @default.
- W2507608410 hasAuthorship W2507608410A5033440492 @default.
- W2507608410 hasAuthorship W2507608410A5035783276 @default.