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- W2507645504 endingPage "160165" @default.
- W2507645504 startingPage "160165" @default.
- W2507645504 abstract "Classical MHC class II (MHCII) proteins present peptides for CD4 + T-cell surveillance and are by far the most prominent risk factor for a number of autoimmune disorders. To date, many studies have shown that this link between particular MHCII alleles and disease depends on the MHCII's particular ability to bind and present certain peptides in specific physiological contexts. However, less attention has been paid to the non-classical MHCII molecule human leucocyte antigen-DM, which catalyses peptide exchange on classical MHCII proteins acting as a peptide editor. DM function impacts the presentation of both antigenic peptides in the periphery and key self-peptides during T-cell development in the thymus. In this way, DM activity directly influences the response to pathogens, as well as mechanisms of self-tolerance acquisition. While decreased DM editing of particular MHCII proteins has been proposed to be related to autoimmune disorders, no experimental evidence for different DM catalytic properties had been reported until recently. Biochemical and structural investigations, together with new animal models of loss of DM activity, have provided an attractive foundation for identifying different catalytic efficiencies for DM allotypes. Here, we revisit the current knowledge of DM function and discuss how DM function may impart autoimmunity at the organism level." @default.
- W2507645504 created "2016-09-16" @default.
- W2507645504 creator A5033245106 @default.
- W2507645504 creator A5043758537 @default.
- W2507645504 creator A5052564982 @default.
- W2507645504 creator A5054910477 @default.
- W2507645504 creator A5091534159 @default.
- W2507645504 date "2016-08-01" @default.
- W2507645504 modified "2023-09-23" @default.
- W2507645504 title "Human leukocyte Antigen-DM polymorphisms in autoimmune diseases" @default.
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