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- W2507717923 abstract "The bispyranopyrazoles ( 4a , 4b , 4c , 4d , 4e , 4f , 4g ) were synthesized from the reactions of dibenzaldehydes ( 2a , 2b , 2c , 2d , 2e , 2f , 2g ) with 3‐methylpyrazole‐5‐one 3 and malononitrile by refluxing under alcoholic medium. The dibenzaldehydes were obtained from the O‐alkylation of 3‐hydroxybenzaldehyde with suitable 1,ω‐dibromoalkanes under the alkaline conditions in the presence of dry EtOH/DMF. The structures of bisheterocyclics were determined from rigorous analysis of their spectral parameters (IR, 1 H‐NMR, 13 C‐NMR, and ESI‐MS). The newly prepared compounds were screened for their antimicrobial activity against seven bacterial and five fungal strains. The DNA photo cleavage potential of these compounds was also evaluated by using agarose gel electrophoresis, and bispyranopyrazoles 4b , 4d and 4e exhibited significant level of DNA photocleavage activity." @default.
- W2507717923 created "2016-09-16" @default.
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- W2507717923 date "2015-09-30" @default.
- W2507717923 modified "2023-10-05" @default.
- W2507717923 title "Synthesis, Antimicrobial Evaluations, and DNA Photo Cleavage Studies of New Bispyranopyrazoles" @default.
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- W2507717923 doi "https://doi.org/10.1002/jhet.2530" @default.
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