FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2507788417> ?p ?o ?g. }

• W2507788417 endingPage "3886" @default.
• W2507788417 startingPage "3878" @default.
• W2507788417 abstract "S100 calcium-binding protein B (S100B) is expressed and released by adipocytes, and is positively correlated with body mass index, however, the direct effects of S100B on adipocytes remain unclear. Bone marrow‑derived mesenchymal stem cells have the capacity to differentiate into osteoblasts and adipocytes, which is important for bone metabolism. The current study aimed to determine the effect of S100B on adipogenesis and osteogenesis. The mouse embryo cell line C3H/10T1/2 was used to build cell models with varying levels of S100B protein expression. Western blot analysis was performed to assess the expression of various marker proteins. Oil red O staining and alizarin red S staining were used to detect adipogenesis and osteogenesis, respectively. S100B overexpression was associated with a significant increase in oil red O staining and a significant reduction in alizarin red S staining. Runt‑related transcription factor‑2 and bone morphogenetic protein 2 expression levels were significantly increased in the S100B underexpression group, however not in the S100B overexpression group. By contrast, the expression levels of the adipogenesis markers peroxisome proliferator‑activated receptor γ and CCAAT‑enhancer‑binding protein α was significantly increased in the S100B overexpression group, however not in the S100B underexpression group. Osteogenesis stimulation increased extracellular signal‑regulated kinase (ERK) phosphorylation, and adipogenesis stimulation increased c‑Jun N‑terminal kinase (JNK) phosphorylation. The results suggest that S100B inhibits osteogenesis, however stimulates adipogenesis. The ERK pathway is involved in the regulation of osteogenesis, whereas the JNK pathway is involved in the regulation of adipogenesis." @default.
• W2507788417 created "2016-09-16" @default.
• W2507788417 creator A5011003329 @default.
• W2507788417 creator A5029032414 @default.
• W2507788417 creator A5031493172 @default.
• W2507788417 creator A5031881689 @default.
• W2507788417 creator A5031993303 @default.
• W2507788417 creator A5033902383 @default.
• W2507788417 creator A5043484277 @default.
• W2507788417 creator A5045067652 @default.
• W2507788417 creator A5071787113 @default.
• W2507788417 creator A5087541016 @default.
• W2507788417 creator A5087986828 @default.
• W2507788417 date "2016-09-01" @default.
• W2507788417 modified "2023-10-16" @default.
• W2507788417 title "S100B suppresses the differentiation of C3H/10T1/2 murine embryonic mesenchymal cells into osteoblasts" @default.
• W2507788417 cites W1907219612 @default.
• W2507788417 cites W1964806084 @default.
• W2507788417 cites W1964811649 @default.
• W2507788417 cites W1973604810 @default.
• W2507788417 cites W1974847865 @default.
• W2507788417 cites W1980566571 @default.
• W2507788417 cites W1985091677 @default.
• W2507788417 cites W1990754061 @default.
• W2507788417 cites W2003406206 @default.
• W2507788417 cites W2004906966 @default.
• W2507788417 cites W2008604876 @default.
• W2507788417 cites W2018006618 @default.
• W2507788417 cites W2020217241 @default.
• W2507788417 cites W2029678968 @default.
• W2507788417 cites W2031558243 @default.
• W2507788417 cites W2042142213 @default.
• W2507788417 cites W2046580038 @default.
• W2507788417 cites W2080620471 @default.
• W2507788417 cites W2081318222 @default.
• W2507788417 cites W2083114484 @default.
• W2507788417 cites W2094864260 @default.
• W2507788417 cites W2109934714 @default.
• W2507788417 cites W2126682274 @default.
• W2507788417 cites W2128410834 @default.
• W2507788417 cites W2134847038 @default.
• W2507788417 cites W2151428505 @default.
• W2507788417 cites W2152590344 @default.
• W2507788417 doi "https://doi.org/10.3892/mmr.2016.5697" @default.
• W2507788417 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27601207" @default.
• W2507788417 hasPublicationYear "2016" @default.
• W2507788417 type Work @default.
• W2507788417 sameAs 2507788417 @default.
• W2507788417 citedByCount "9" @default.
• W2507788417 countsByYear W25077884172018 @default.
• W2507788417 countsByYear W25077884172019 @default.
• W2507788417 countsByYear W25077884172020 @default.
• W2507788417 countsByYear W25077884172021 @default.
• W2507788417 countsByYear W25077884172022 @default.
• W2507788417 countsByYear W25077884172023 @default.
• W2507788417 crossrefType "journal-article" @default.
• W2507788417 hasAuthorship W2507788417A5011003329 @default.
• W2507788417 hasAuthorship W2507788417A5029032414 @default.
• W2507788417 hasAuthorship W2507788417A5031493172 @default.
• W2507788417 hasAuthorship W2507788417A5031881689 @default.
• W2507788417 hasAuthorship W2507788417A5031993303 @default.
• W2507788417 hasAuthorship W2507788417A5033902383 @default.
• W2507788417 hasAuthorship W2507788417A5043484277 @default.
• W2507788417 hasAuthorship W2507788417A5045067652 @default.
• W2507788417 hasAuthorship W2507788417A5071787113 @default.
• W2507788417 hasAuthorship W2507788417A5087541016 @default.
• W2507788417 hasAuthorship W2507788417A5087986828 @default.
• W2507788417 hasBestOaLocation W25077884171 @default.
• W2507788417 hasConcept C104317684 @default.
• W2507788417 hasConcept C122927707 @default.
• W2507788417 hasConcept C126322002 @default.
• W2507788417 hasConcept C134018914 @default.
• W2507788417 hasConcept C148738053 @default.
• W2507788417 hasConcept C153911025 @default.
• W2507788417 hasConcept C184235292 @default.
• W2507788417 hasConcept C185592680 @default.
• W2507788417 hasConcept C198826908 @default.
• W2507788417 hasConcept C2780806160 @default.
• W2507788417 hasConcept C55493867 @default.
• W2507788417 hasConcept C57074206 @default.
• W2507788417 hasConcept C71924100 @default.
• W2507788417 hasConcept C86803240 @default.
• W2507788417 hasConcept C95444343 @default.
• W2507788417 hasConcept C97029542 @default.
• W2507788417 hasConceptScore W2507788417C104317684 @default.
• W2507788417 hasConceptScore W2507788417C122927707 @default.
• W2507788417 hasConceptScore W2507788417C126322002 @default.
• W2507788417 hasConceptScore W2507788417C134018914 @default.
• W2507788417 hasConceptScore W2507788417C148738053 @default.
• W2507788417 hasConceptScore W2507788417C153911025 @default.
• W2507788417 hasConceptScore W2507788417C184235292 @default.
• W2507788417 hasConceptScore W2507788417C185592680 @default.
• W2507788417 hasConceptScore W2507788417C198826908 @default.
• W2507788417 hasConceptScore W2507788417C2780806160 @default.
• W2507788417 hasConceptScore W2507788417C55493867 @default.
• W2507788417 hasConceptScore W2507788417C57074206 @default.
• W2507788417 hasConceptScore W2507788417C71924100 @default.
• W2507788417 hasConceptScore W2507788417C86803240 @default.

• next