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- W2507933604 abstract "A general and simple synthesis of 2,4,6-trisubstituted pyridines and fused pyridine-2-ones from bromoacetic acid is developed via a DMAP-promoted in situ activation strategy. In this protocol, readily accessible bromoacetic acid has been effectively employed as a 2C synthon to undergo formal [2+4] cycloadditions with diverse acyclic and cyclic 1-azadienes. Low costs of the reagents and materials, mild reaction conditions and broad functional-group tolerance make this protocol applicable for practical and scalable synthesis." @default.
- W2507933604 created "2016-09-16" @default.
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- W2507933604 date "2016-10-01" @default.
- W2507933604 modified "2023-10-03" @default.
- W2507933604 title "DMAP-promoted in situ activation of bromoacetic acid as a 2-carbon synthon for facile synthesis of pyridines and fused pyridin-2-ones" @default.
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- W2507933604 doi "https://doi.org/10.1016/j.tet.2016.08.062" @default.
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