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- W2508082603 abstract "The use of medicinal plants is one of the most ancient practices of humanity. The Qualea grandiflora Mart species is popularly used as a medical treatment for asthma, ulcer and inflammatory processes. The porpouse of this work is evaluate the acute toxicity of hydroethanolic Qualea grandiflora Mart leaf extract in Swiss Webster albino mice, by Hippocratic test. The amount of 48 mice were tested, divided into groups, of which 6 groups have been treated using hydro-ethanolic Qualea grandiflora Mart extract (EHEQGM) , in 25, 50, 100, 250, 500 and 1000 mg/kg doses, orally administered and 6 groups have been treated usind EHEQGM intraperitoneal injection, in the same doses. An animal has been used for each dose, receiving dissolvent liquid (distilled water and DMSO, 10 ml/kg). The animals were watched individually, into appropriate cages (open field), instantly, after 15 and 30 minutes and after 1, 2, 4 and 8 hours. They were also watched once per day, during 14 days. Some behavioral changes were noted in both groups and there were deaths in i.p 500/1000 mg/kg groups, but the results of the histopathological examination did not present significant changes in these animals organs. Some noted undesirable effects during this study by assessed parameters show that the use of Qualea grandiflora Mart in high doses should be avoided. Descriptors: Acute Toxicity; Plants, Medicinal; Mice." @default.
- W2508082603 created "2016-09-16" @default.
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- W2508082603 date "2016-01-01" @default.
- W2508082603 modified "2023-09-27" @default.
- W2508082603 title "Toxicidade aguda e avaliação anatomopatológica em camundongos tratados com extrato da Qualea grandiflora Mart Acute toxicity and anatomopathological assessment in mice treated with Qualea grandiflora Mart extract Toxicidad aguda y evaluación anatomopatológica en ratones de laboratorio tratados con extracto de Qualea grandiflora Mart" @default.
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- W2508082603 hasPublicationYear "2016" @default.
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