FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2508124992> ?p ?o ?g. }

• W2508124992 endingPage "71" @default.
• W2508124992 startingPage "58" @default.
• W2508124992 abstract "Abstract Aim The transcriptional cofactor receptor‐interacting protein 140 ( RIP 140) is known as a deleterious regulator of cardiac mitochondrial function and energy metabolic homeostasis. This study revealed that RIP 140 repressed Sirtuin 3 ( SIRT 3), a mitochondrial deacetylase that plays an important role in regulating cardiac function. Methods RIP 140 was overexpressed by adenovirus infection or was knocked down by RNA interference in neonatal rat cardiomyocytes. Results RIP 140 overexpression repressed, while RIP 140 silencing elevated the expression and activity of SIRT 3. Ad‐ RIP 140 enhanced the expressions of the cardiac hypertrophic markers and increased cardiomyocyte surface area, whereas SIRT 3 overexpression prevented the effect of Ad‐ RIP 140. Additionally, SIRT 3 overexpression reversed Ad‐ RIP 140‐induced mitochondrial dysfunction and energy metabolic dysfunction, such as increase in oxidative stress, decrease in mitochondrial membrane potential and ATP production, as well as downregulation of mitochondrial DNA ‐encoded genes and genes related to mitochondrial genome replication and transcription, mitochondrial oxidative phosphorylation and fatty acid oxidation. In contrast, SIRT 3 silencing exacerbated RIP 140‐induced cardiomyocyte hypertrophy and mitochondrial dysfunction. Furthermore, the repression of SIRT 3 by RIP 140 was dependent on estrogen‐related receptor‐α ( ERR α). The involvement of peroxisome proliferator‐activated receptor‐γ coactivator‐1α ( PGC ‐1α) was ruled out of SIRT 3 suppression by RIP 140. RIP 140 and PGC ‐1α might act as functional antagonists on the regulation of SIRT 3. Conclusion This study indicates that suppression of SIRT 3 by RIP 140 facilitates the development of cardiomyocyte hypertrophy, mitochondrial dysfunction and energy metabolic dysfunction. Strategies targeting inhibition of RIP 140 and upregulation of SIRT 3 might improve cardiac energy metabolism and suggest therapeutic potential for heart diseases." @default.
• W2508124992 created "2016-09-16" @default.
• W2508124992 creator A5008707189 @default.
• W2508124992 creator A5009067006 @default.
• W2508124992 creator A5018433390 @default.
• W2508124992 creator A5023522137 @default.
• W2508124992 creator A5027965844 @default.
• W2508124992 creator A5030900462 @default.
• W2508124992 creator A5038096051 @default.
• W2508124992 creator A5061233122 @default.
• W2508124992 creator A5069561260 @default.
• W2508124992 creator A5075417991 @default.
• W2508124992 creator A5082120847 @default.
• W2508124992 date "2016-10-12" @default.
• W2508124992 modified "2023-10-15" @default.
• W2508124992 title "Receptor-interacting Protein 140 represses Sirtuin 3 to facilitate hypertrophy, mitochondrial dysfunction and energy metabolic dysfunction in cardiomyocytes" @default.
• W2508124992 cites W1607149064 @default.
• W2508124992 cites W1965935659 @default.
• W2508124992 cites W1967964480 @default.
• W2508124992 cites W1969437142 @default.
• W2508124992 cites W1970060454 @default.
• W2508124992 cites W1971082641 @default.
• W2508124992 cites W1990295975 @default.
• W2508124992 cites W1996934314 @default.
• W2508124992 cites W2010312612 @default.
• W2508124992 cites W2013841882 @default.
• W2508124992 cites W2016736578 @default.
• W2508124992 cites W2037229939 @default.
• W2508124992 cites W2039374791 @default.
• W2508124992 cites W2039733199 @default.
• W2508124992 cites W2048672285 @default.
• W2508124992 cites W2052751736 @default.
• W2508124992 cites W2055208928 @default.
• W2508124992 cites W2067840834 @default.
• W2508124992 cites W2075747312 @default.
• W2508124992 cites W2084481577 @default.
• W2508124992 cites W2084708023 @default.
• W2508124992 cites W2086183702 @default.
• W2508124992 cites W2086563845 @default.
• W2508124992 cites W2091457094 @default.
• W2508124992 cites W2096192036 @default.
• W2508124992 cites W2097793695 @default.
• W2508124992 cites W2100476416 @default.
• W2508124992 cites W2106085263 @default.
• W2508124992 cites W2117473844 @default.
• W2508124992 cites W2118397007 @default.
• W2508124992 cites W2121314366 @default.
• W2508124992 cites W2130622650 @default.
• W2508124992 cites W2134567873 @default.
• W2508124992 cites W2143958727 @default.
• W2508124992 cites W2153819921 @default.
• W2508124992 cites W219187680 @default.
• W2508124992 doi "https://doi.org/10.1111/apha.12800" @default.
• W2508124992 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27614093" @default.
• W2508124992 hasPublicationYear "2016" @default.
• W2508124992 type Work @default.
• W2508124992 sameAs 2508124992 @default.
• W2508124992 citedByCount "18" @default.
• W2508124992 countsByYear W25081249922017 @default.
• W2508124992 countsByYear W25081249922018 @default.
• W2508124992 countsByYear W25081249922019 @default.
• W2508124992 countsByYear W25081249922020 @default.
• W2508124992 countsByYear W25081249922021 @default.
• W2508124992 countsByYear W25081249922022 @default.
• W2508124992 crossrefType "journal-article" @default.
• W2508124992 hasAuthorship W2508124992A5008707189 @default.
• W2508124992 hasAuthorship W2508124992A5009067006 @default.
• W2508124992 hasAuthorship W2508124992A5018433390 @default.
• W2508124992 hasAuthorship W2508124992A5023522137 @default.
• W2508124992 hasAuthorship W2508124992A5027965844 @default.
• W2508124992 hasAuthorship W2508124992A5030900462 @default.
• W2508124992 hasAuthorship W2508124992A5038096051 @default.
• W2508124992 hasAuthorship W2508124992A5061233122 @default.
• W2508124992 hasAuthorship W2508124992A5069561260 @default.
• W2508124992 hasAuthorship W2508124992A5075417991 @default.
• W2508124992 hasAuthorship W2508124992A5082120847 @default.
• W2508124992 hasConcept C104317684 @default.
• W2508124992 hasConcept C119056186 @default.
• W2508124992 hasConcept C119157956 @default.
• W2508124992 hasConcept C126322002 @default.
• W2508124992 hasConcept C127561419 @default.
• W2508124992 hasConcept C134018914 @default.
• W2508124992 hasConcept C2776536020 @default.
• W2508124992 hasConcept C2780561631 @default.
• W2508124992 hasConcept C28859421 @default.
• W2508124992 hasConcept C55493867 @default.
• W2508124992 hasConcept C71924100 @default.
• W2508124992 hasConcept C86803240 @default.
• W2508124992 hasConcept C95444343 @default.
• W2508124992 hasConceptScore W2508124992C104317684 @default.
• W2508124992 hasConceptScore W2508124992C119056186 @default.
• W2508124992 hasConceptScore W2508124992C119157956 @default.
• W2508124992 hasConceptScore W2508124992C126322002 @default.
• W2508124992 hasConceptScore W2508124992C127561419 @default.
• W2508124992 hasConceptScore W2508124992C134018914 @default.
• W2508124992 hasConceptScore W2508124992C2776536020 @default.
• W2508124992 hasConceptScore W2508124992C2780561631 @default.
• W2508124992 hasConceptScore W2508124992C28859421 @default.

• next