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• W2508171925 abstract "In systems biology, network models are often used to study interactions among cellular components, a salient aim being to develop drugs and therapeutic mechanisms to change the dynamical behavior of the network to avoid undesirable phenotypes. Owing to limited knowledge, model uncertainty is commonplace and network dynamics can be updated in different ways, thereby giving multiple dynamic trajectories, that is, dynamics uncertainty. In this manuscript, we propose an experimental design method that can effectively reduce the dynamics uncertainty and improve performance in an interaction-based network. Both dynamics uncertainty and experimental error are quantified with respect to the modeling objective, herein, therapeutic intervention. The aim of experimental design is to select among a set of candidate experiments the experiment whose outcome, when applied to the network model, maximally reduces the dynamics uncertainty pertinent to the intervention objective." @default.
• W2508171925 created "2016-09-16" @default.
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• W2508171925 date "2018-01-01" @default.
• W2508171925 modified "2023-09-26" @default.
• W2508171925 title "Optimal Objective-Based Experimental Design for Uncertain Dynamical Gene Networks with Experimental Error" @default.
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• W2508171925 doi "https://doi.org/10.1109/tcbb.2016.2602873" @default.
• W2508171925 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5845823" @default.
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