FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2508196303> ?p ?o ?g. }

• W2508196303 endingPage "4496" @default.
• W2508196303 startingPage "4489" @default.
• W2508196303 abstract "Type 2 diabetes is associated with a higher risk for major osteoporotic fracture (MOF) and hip fracture than predicted by the World Health Organization fracture risk assessment (FRAX) tool.The objective of the study was to examine the impact of diabetes duration on fracture risk.Using a clinical dual-energy x-ray absorptiometry registry linked with the Manitoba administrative databases, we identified all women age 40 years or older with 10 or more years of prior health care coverage undergoing hip dual-energy x-ray absorptiometry measurements (1996-2013). Incident MOF and incident hip fractures were each studied over 7 years. Cox proportional hazards models were adjusted for FRAX (FRAX adjusted) and then FRAX plus comorbidity, falls, osteoporosis therapy, or insulin (fully adjusted). FRAX calibration was assessed comparing observed vs predicted probabilities.There were 49 098 women without and 8840 women with diabetes (31.4% >10 y duration; 20.1% 5-10 y; 23.7% <5 y; 24.8% new onset). In FRAX-adjusted analyses, only duration longer than 10 years was associated with a higher risk for MOF (hazard ratio [HR] 1.47, 95% confidence interval [CI] 1.30-1.66), and this was similar in the fully adjusted models (HR 1.34, 95% CI 1.17-1.54). In contrast, a higher risk for hip fracture was seen for all durations in a dose-dependent fashion (eg, FRAX adjusted HR 2.10, 95% CI 1.71-2.59 for duration >10 y vs HR 1.32, 95% CI 1.03-1.69 for new onset). FRAX significantly underestimated the MOF risk (calibration ratio 1.24, 95% CI 1.08-1.39) and hip fracture risk (1.93, 95% CI 1.50-2.35) in those with a diabetes duration longer than 10 years.Diabetes is a FRAX-independent risk factor for MOF only in women with a long duration of diabetes, but diabetes increases hip fracture risk, regardless of duration. Those with diabetes longer than 10 years are at particularly high risk of fracture, and this elevated risk is currently underestimated by FRAX." @default.
• W2508196303 created "2016-09-16" @default.
• W2508196303 creator A5024756058 @default.
• W2508196303 creator A5037004738 @default.
• W2508196303 creator A5053331431 @default.
• W2508196303 creator A5059888726 @default.
• W2508196303 creator A5067563008 @default.
• W2508196303 creator A5075674266 @default.
• W2508196303 creator A5082999537 @default.
• W2508196303 creator A5089741816 @default.
• W2508196303 date "2016-11-01" @default.
• W2508196303 modified "2023-09-23" @default.
• W2508196303 title "Longer Duration of Diabetes Strongly Impacts Fracture Risk Assessment: The Manitoba BMD Cohort" @default.
• W2508196303 cites W1562584460 @default.
• W2508196303 cites W1972328688 @default.
• W2508196303 cites W1978759916 @default.
• W2508196303 cites W1979347479 @default.
• W2508196303 cites W1988666864 @default.
• W2508196303 cites W1993857965 @default.
• W2508196303 cites W2008679328 @default.
• W2508196303 cites W2009804188 @default.
• W2508196303 cites W2024736284 @default.
• W2508196303 cites W2055675683 @default.
• W2508196303 cites W2057210449 @default.
• W2508196303 cites W2067733022 @default.
• W2508196303 cites W2076599880 @default.
• W2508196303 cites W2091232091 @default.
• W2508196303 cites W2091272943 @default.
• W2508196303 cites W2092233526 @default.
• W2508196303 cites W2096966227 @default.
• W2508196303 cites W2116288435 @default.
• W2508196303 cites W2119946053 @default.
• W2508196303 cites W2125637498 @default.
• W2508196303 cites W2141260918 @default.
• W2508196303 cites W2147642606 @default.
• W2508196303 cites W2150333580 @default.
• W2508196303 cites W2152158955 @default.
• W2508196303 cites W2157441025 @default.
• W2508196303 cites W2203793870 @default.
• W2508196303 cites W2327858603 @default.
• W2508196303 cites W2413491805 @default.
• W2508196303 doi "https://doi.org/10.1210/jc.2016-2569" @default.
• W2508196303 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5095256" @default.
• W2508196303 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27603908" @default.
• W2508196303 hasPublicationYear "2016" @default.
• W2508196303 type Work @default.
• W2508196303 sameAs 2508196303 @default.
• W2508196303 citedByCount "85" @default.
• W2508196303 countsByYear W25081963032017 @default.
• W2508196303 countsByYear W25081963032018 @default.
• W2508196303 countsByYear W25081963032019 @default.
• W2508196303 countsByYear W25081963032020 @default.
• W2508196303 countsByYear W25081963032021 @default.
• W2508196303 countsByYear W25081963032022 @default.
• W2508196303 countsByYear W25081963032023 @default.
• W2508196303 crossrefType "journal-article" @default.
• W2508196303 hasAuthorship W2508196303A5024756058 @default.
• W2508196303 hasAuthorship W2508196303A5037004738 @default.
• W2508196303 hasAuthorship W2508196303A5053331431 @default.
• W2508196303 hasAuthorship W2508196303A5059888726 @default.
• W2508196303 hasAuthorship W2508196303A5067563008 @default.
• W2508196303 hasAuthorship W2508196303A5075674266 @default.
• W2508196303 hasAuthorship W2508196303A5082999537 @default.
• W2508196303 hasAuthorship W2508196303A5089741816 @default.
• W2508196303 hasBestOaLocation W25081963031 @default.
• W2508196303 hasConcept C126322002 @default.
• W2508196303 hasConcept C134018914 @default.
• W2508196303 hasConcept C201903717 @default.
• W2508196303 hasConcept C207103383 @default.
• W2508196303 hasConcept C2776541429 @default.
• W2508196303 hasConcept C2776886416 @default.
• W2508196303 hasConcept C2777180221 @default.
• W2508196303 hasConcept C2777525943 @default.
• W2508196303 hasConcept C2778885795 @default.
• W2508196303 hasConcept C2779159551 @default.
• W2508196303 hasConcept C2781440623 @default.
• W2508196303 hasConcept C2994343686 @default.
• W2508196303 hasConcept C44249647 @default.
• W2508196303 hasConcept C50382708 @default.
• W2508196303 hasConcept C555293320 @default.
• W2508196303 hasConcept C71924100 @default.
• W2508196303 hasConcept C72563966 @default.
• W2508196303 hasConceptScore W2508196303C126322002 @default.
• W2508196303 hasConceptScore W2508196303C134018914 @default.
• W2508196303 hasConceptScore W2508196303C201903717 @default.
• W2508196303 hasConceptScore W2508196303C207103383 @default.
• W2508196303 hasConceptScore W2508196303C2776541429 @default.
• W2508196303 hasConceptScore W2508196303C2776886416 @default.
• W2508196303 hasConceptScore W2508196303C2777180221 @default.
• W2508196303 hasConceptScore W2508196303C2777525943 @default.
• W2508196303 hasConceptScore W2508196303C2778885795 @default.
• W2508196303 hasConceptScore W2508196303C2779159551 @default.
• W2508196303 hasConceptScore W2508196303C2781440623 @default.
• W2508196303 hasConceptScore W2508196303C2994343686 @default.
• W2508196303 hasConceptScore W2508196303C44249647 @default.
• W2508196303 hasConceptScore W2508196303C50382708 @default.
• W2508196303 hasConceptScore W2508196303C555293320 @default.
• W2508196303 hasConceptScore W2508196303C71924100 @default.

• next