Matches in SemOpenAlex for { <https://semopenalex.org/work/W2508203418> ?p ?o ?g. }
- W2508203418 endingPage "185" @default.
- W2508203418 startingPage "171" @default.
- W2508203418 abstract "Concurrent use of tobacco and alcohol or psychostimulants represents a major public health concern, with use of one substance influencing consumption of the other. Co-abuse of these drugs leads to substantial negative health outcomes, reduced cessation, and high economic costs, but the underlying mechanisms are poorly understood. Epidemiological data suggest that tobacco use during adolescence plays a particularly significant role. Adolescence is a sensitive period of development marked by major neurobiological maturation of brain regions critical for reward processing, learning and memory, and executive function. Nicotine exposure during this time produces a unique and long-lasting vulnerability to subsequent substance use, likely via actions at cholinergic, dopaminergic, and serotonergic systems. In this review, we discuss recent clinical and preclinical data examining the genetic factors and mechanisms underlying co-use of nicotine and alcohol or cocaine and amphetamines. We evaluate the critical role of nicotinic acetylcholine receptors throughout, and emphasize the dearth of preclinical studies assessing concurrent drug exposure. We stress important age and sex differences in drug responses, and highlight a brief, low-dose nicotine exposure paradigm that may better model early use of tobacco products. The escalating use of e-cigarettes among youth necessitates a closer look at the consequences of early adolescent nicotine exposure on subsequent alcohol and drug abuse." @default.
- W2508203418 created "2016-09-16" @default.
- W2508203418 creator A5008628611 @default.
- W2508203418 creator A5063597660 @default.
- W2508203418 creator A5088026484 @default.
- W2508203418 date "2016-08-17" @default.
- W2508203418 modified "2023-09-26" @default.
- W2508203418 title "Mechanisms and genetic factors underlying co-use of nicotine and alcohol or other drugs of abuse" @default.
- W2508203418 cites W1055002487 @default.
- W2508203418 cites W1497924333 @default.
- W2508203418 cites W1555930276 @default.
- W2508203418 cites W1562558986 @default.
- W2508203418 cites W1842999955 @default.
- W2508203418 cites W1851873052 @default.
- W2508203418 cites W1881616800 @default.
- W2508203418 cites W1905173197 @default.
- W2508203418 cites W1936223934 @default.
- W2508203418 cites W1941246444 @default.
- W2508203418 cites W1945666908 @default.
- W2508203418 cites W1964486780 @default.
- W2508203418 cites W1964516189 @default.
- W2508203418 cites W1964806845 @default.
- W2508203418 cites W1965616809 @default.
- W2508203418 cites W1966285913 @default.
- W2508203418 cites W1967487244 @default.
- W2508203418 cites W1967870055 @default.
- W2508203418 cites W1968217212 @default.
- W2508203418 cites W1972401127 @default.
- W2508203418 cites W1972493675 @default.
- W2508203418 cites W1973295491 @default.
- W2508203418 cites W1973357385 @default.
- W2508203418 cites W1974317108 @default.
- W2508203418 cites W1974604729 @default.
- W2508203418 cites W1975812147 @default.
- W2508203418 cites W1976270028 @default.
- W2508203418 cites W1976317891 @default.
- W2508203418 cites W1976681051 @default.
- W2508203418 cites W1977173142 @default.
- W2508203418 cites W1980005460 @default.
- W2508203418 cites W1981574077 @default.
- W2508203418 cites W1981827116 @default.
- W2508203418 cites W1982050055 @default.
- W2508203418 cites W1982214096 @default.
- W2508203418 cites W1982930863 @default.
- W2508203418 cites W1983634188 @default.
- W2508203418 cites W1983676227 @default.
- W2508203418 cites W1984596649 @default.
- W2508203418 cites W1984670879 @default.
- W2508203418 cites W1985408870 @default.
- W2508203418 cites W1985545560 @default.
- W2508203418 cites W1985645068 @default.
- W2508203418 cites W1986230975 @default.
- W2508203418 cites W1987119564 @default.
- W2508203418 cites W1993087404 @default.
- W2508203418 cites W1993352912 @default.
- W2508203418 cites W1993398563 @default.
- W2508203418 cites W1995328406 @default.
- W2508203418 cites W1997302441 @default.
- W2508203418 cites W1998106835 @default.
- W2508203418 cites W1998138099 @default.
- W2508203418 cites W1998145125 @default.
- W2508203418 cites W1998838771 @default.
- W2508203418 cites W1999497444 @default.
- W2508203418 cites W2000139363 @default.
- W2508203418 cites W2000144723 @default.
- W2508203418 cites W2000817992 @default.
- W2508203418 cites W2001913229 @default.
- W2508203418 cites W2003224343 @default.
- W2508203418 cites W2003586902 @default.
- W2508203418 cites W2005542690 @default.
- W2508203418 cites W2005605280 @default.
- W2508203418 cites W2006049216 @default.
- W2508203418 cites W2008134665 @default.
- W2508203418 cites W2008808029 @default.
- W2508203418 cites W2008931571 @default.
- W2508203418 cites W2010561612 @default.
- W2508203418 cites W2011020105 @default.
- W2508203418 cites W2011491858 @default.
- W2508203418 cites W2013221361 @default.
- W2508203418 cites W2015334840 @default.
- W2508203418 cites W2015626914 @default.
- W2508203418 cites W2015725514 @default.
- W2508203418 cites W2016795990 @default.
- W2508203418 cites W2020818929 @default.
- W2508203418 cites W2021463344 @default.
- W2508203418 cites W2021927617 @default.
- W2508203418 cites W2025894240 @default.
- W2508203418 cites W2026049415 @default.
- W2508203418 cites W2026469041 @default.
- W2508203418 cites W2027525002 @default.
- W2508203418 cites W2027726712 @default.
- W2508203418 cites W2028813128 @default.
- W2508203418 cites W2030376896 @default.
- W2508203418 cites W2030813390 @default.
- W2508203418 cites W2031865166 @default.
- W2508203418 cites W2033170773 @default.
- W2508203418 cites W2033698523 @default.
- W2508203418 cites W2033912508 @default.