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- W2508298397 abstract "Normal progression of genetic recombination requires timely degradation of many proteins, but little is known about the proteolytic mechanism. The ARA BIDOPSIS SKP1-LIKE1 (ASK1) protein is a compo nent of the Skpl-Cullin-F-box-protein (SCF) ubiquitin ligases that target a variety of proteins for degradation via the 26S proteasome pathway. Previous studies indi cate that the early defects of the mutant askl-1 occur in a prophase-I period overlapping with the period of homologous recombination. We provide evidence in this report that ASK1 is predominately expressed from lep totene to pachytene, and negatively regulates recombi nation. First, the ASK1 transcript was found not to co exist with that of its closest homolog ASK2 only during prophase I of male meiosis, suggesting that ASK1 is functionally non-redundant only in prophase I. Second, the peak level of an ASK 1-green fluorescence protein (GFP) fusion protein expressed by an ASK1 promoter region occurred only from leptotene to pachytene. The ASK 1-GFP in a dominant negative fashion resulted in abnormal tetrads resembling those of the askl-1 mutant, supporting that the expression timing of the ASK 1-GFP in male meiocytes reflects the expression timing of the endogenous ASK1. Lastly, using a marker for recom bination events, a significant increase in recombination frequency was detected in plants heterozygous for askl 1. These results indicate that ASK1 normally plays a repressive role in male recombination in Arabidopsis." @default.
- W2508298397 created "2016-09-16" @default.
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- W2508298397 date "2006-01-01" @default.
- W2508298397 modified "2023-09-27" @default.
- W2508298397 title "The ARABIDOPSIS SKP1-LIKE1 (ASK1) protein acts predominately from leptotene to pachytene and represses homologous recombination" @default.
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