FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2508392020> ?p ?o ?g. }

• W2508392020 abstract "Abstract Background & Aims 18F-fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET-CT) scan has been increasingly used for initial staging and response evaluation in patients with lymphomas, and its clinical utility is well established in Hodgkin’s lymphoma (HL) as well as in diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL). However, its role remains undetermined in marginal zone lymphomas (MZL), due to its relatively low FDG avidity as well as small numbers of patients in the Western countries although it is the most common type of indolent lymphoma in Korea. Thus, we aimed to assess the prognostic significance of PET-CT scan performed after first-line therapy in patients with MZL. Patients & Methods We retrospectively reviewed the medical records of a total of 194 patients with pathologically confirmed MZL in the Asan Medical Center between February 2003 and February 2011. Post-treatment FDG PET-CT scan was defined as which performed during the periods of 2 to 4 weeks after the completion of chemotherapy or 7 to 9 weeks after radiotherapy. Among them, we identified 32 patients with evaluable pretreatment, interim and post-treatment PET-CT scans who received chemotherapy. We investigated the prognostic significance of maximum standardized uptake value (SUVmax) at pretreatment PET-CT and metabolic complete response (mCR) at post-treatment PET-CT. The log-rank test was used to assess the correlation of event-free survival (EFS) and overall survival (OS) with baseline SUVmax or the presence of mCR. All categorical variables were analyzed using Chi-square test or Fisher’s exact test. Results In a total of analyzable 32 patients, histopathologic subtypes of them were as follow: Mucosa-associated lymphoid tissue (MALT) lymphoma (n=14, 43.8%), nodal MZL (n=17, 53.1%), and splenic MZL (n=1, 3.2%). The median SUVmax in pretreatment PET-CT was 5.3 (range, 1.3 – 18.8). There were no significant associations of SUVmax (cutoff: 5.3) at pretreatment PET-CT to mCR in both post-treatment and interim PET-CT scans (p =0.694 and p=0.723, respectively). However, high SUV group (SUVmax at baseline PET-CT >5.3) showed inferior 5-year EFS and OS to low SUV group (¡Â 5.3) with marginal statistical significicance (p=-0.072 and p=0.101, respectively). With a median follow-up duration of 41 months (range, 9 to 99 months), 5-year OS and EFS rate were 87.9% and 43.9%, respectively. 5-year EFS was significantly superior in patients who attained mCR at post-treatment PET-CT (p =0.010, 55.0% to 0%), and also in interim PET-CT (p=0.007, 70.6% to 13.1%). In addition, patients who attained early mCR showed significantly better 5-year EFS than patients of delayed and never mCR groups (p=0.011, 70.6% to 22.5%, and 0%). Conclusion In our study cohort, patients with low SUVmax (¡Â 5.3) in pretreatment PET-CT showed strong trends of superior EFS and OS. More importantly, early attained mCR and mCR at post-treatment PET-CT were independent predictors of higher 5-year EFS rates. Disclosures: No relevant conflicts of interest to declare." @default.
• W2508392020 created "2016-09-16" @default.
• W2508392020 creator A5001984432 @default.
• W2508392020 creator A5002062627 @default.
• W2508392020 creator A5017557363 @default.
• W2508392020 creator A5022379369 @default.
• W2508392020 creator A5032840567 @default.
• W2508392020 creator A5038188064 @default.
• W2508392020 creator A5044958787 @default.
• W2508392020 creator A5049407736 @default.
• W2508392020 creator A5049646227 @default.
• W2508392020 creator A5054938224 @default.
• W2508392020 creator A5075714089 @default.
• W2508392020 creator A5089689144 @default.
• W2508392020 date "2013-11-15" @default.
• W2508392020 modified "2023-09-29" @default.
• W2508392020 title "Prognostic Significance Of Positron Emission Tomography-Computed Tomography In Patients With Marginal Zone Lymphoma" @default.
• W2508392020 doi "https://doi.org/10.1182/blood.v122.21.4324.4324" @default.
• W2508392020 hasPublicationYear "2013" @default.
• W2508392020 type Work @default.
• W2508392020 sameAs 2508392020 @default.
• W2508392020 citedByCount "0" @default.
• W2508392020 crossrefType "journal-article" @default.
• W2508392020 hasAuthorship W2508392020A5001984432 @default.
• W2508392020 hasAuthorship W2508392020A5002062627 @default.
• W2508392020 hasAuthorship W2508392020A5017557363 @default.
• W2508392020 hasAuthorship W2508392020A5022379369 @default.
• W2508392020 hasAuthorship W2508392020A5032840567 @default.
• W2508392020 hasAuthorship W2508392020A5038188064 @default.
• W2508392020 hasAuthorship W2508392020A5044958787 @default.
• W2508392020 hasAuthorship W2508392020A5049407736 @default.
• W2508392020 hasAuthorship W2508392020A5049646227 @default.
• W2508392020 hasAuthorship W2508392020A5054938224 @default.
• W2508392020 hasAuthorship W2508392020A5075714089 @default.
• W2508392020 hasAuthorship W2508392020A5089689144 @default.
• W2508392020 hasConcept C10515644 @default.
• W2508392020 hasConcept C126322002 @default.
• W2508392020 hasConcept C126838900 @default.
• W2508392020 hasConcept C144301174 @default.
• W2508392020 hasConcept C199374082 @default.
• W2508392020 hasConcept C2775842073 @default.
• W2508392020 hasConcept C2777058707 @default.
• W2508392020 hasConcept C2778559949 @default.
• W2508392020 hasConcept C2779338263 @default.
• W2508392020 hasConcept C2989005 @default.
• W2508392020 hasConcept C38180746 @default.
• W2508392020 hasConcept C66339696 @default.
• W2508392020 hasConcept C71924100 @default.
• W2508392020 hasConceptScore W2508392020C10515644 @default.
• W2508392020 hasConceptScore W2508392020C126322002 @default.
• W2508392020 hasConceptScore W2508392020C126838900 @default.
• W2508392020 hasConceptScore W2508392020C144301174 @default.
• W2508392020 hasConceptScore W2508392020C199374082 @default.
• W2508392020 hasConceptScore W2508392020C2775842073 @default.
• W2508392020 hasConceptScore W2508392020C2777058707 @default.
• W2508392020 hasConceptScore W2508392020C2778559949 @default.
• W2508392020 hasConceptScore W2508392020C2779338263 @default.
• W2508392020 hasConceptScore W2508392020C2989005 @default.
• W2508392020 hasConceptScore W2508392020C38180746 @default.
• W2508392020 hasConceptScore W2508392020C66339696 @default.
• W2508392020 hasConceptScore W2508392020C71924100 @default.
• W2508392020 hasLocation W25083920201 @default.
• W2508392020 hasOpenAccess W2508392020 @default.
• W2508392020 hasPrimaryLocation W25083920201 @default.
• W2508392020 hasRelatedWork W1577052032 @default.
• W2508392020 hasRelatedWork W1788986263 @default.
• W2508392020 hasRelatedWork W1998024510 @default.
• W2508392020 hasRelatedWork W201456048 @default.
• W2508392020 hasRelatedWork W2023406498 @default.
• W2508392020 hasRelatedWork W2518372085 @default.
• W2508392020 hasRelatedWork W2552834691 @default.
• W2508392020 hasRelatedWork W2562483421 @default.
• W2508392020 hasRelatedWork W2587181712 @default.
• W2508392020 hasRelatedWork W2913435023 @default.
• W2508392020 hasRelatedWork W2978428646 @default.
• W2508392020 hasRelatedWork W3028832267 @default.
• W2508392020 hasRelatedWork W3029222696 @default.
• W2508392020 hasRelatedWork W3029468956 @default.
• W2508392020 hasRelatedWork W3029700663 @default.
• W2508392020 hasRelatedWork W3030018262 @default.
• W2508392020 hasRelatedWork W3030305290 @default.
• W2508392020 hasRelatedWork W3032777672 @default.
• W2508392020 hasRelatedWork W3196729012 @default.
• W2508392020 hasRelatedWork W336839387 @default.
• W2508392020 isParatext "false" @default.
• W2508392020 isRetracted "false" @default.
• W2508392020 magId "2508392020" @default.
• W2508392020 workType "article" @default.