FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2508431504> ?p ?o ?g. }

• W2508431504 endingPage "267" @default.
• W2508431504 startingPage "261" @default.
• W2508431504 abstract "During an infection or inflammation, several drug-metabolizing enzymes in the liver are down-regulated, including cytochrome P450 iso-enzymes. Since voriconazole is extensively metabolized by cytochrome P450 iso-enzymes, the metabolism of voriconazole can be influenced during inflammation via reduced clearance of the drug, resulting in higher voriconazole trough concentrations.To investigate prospectively the influence of inflammation on voriconazole metabolism and voriconazole trough concentrations.A prospective observational study was performed at the University Medical Center Groningen. Patients were eligible for inclusion if they were ≥18 years old and treated with voriconazole. Voriconazole and voriconazole-N-oxide concentrations were determined in discarded blood samples. To determine the degree of inflammation, C-reactive protein (CRP) concentrations were used. Subsequently, a longitudinal data analysis was performed to assess the effect of inflammation on the metabolic ratio and voriconazole trough concentration.Thirty-four patients were included. In total 489 voriconazole trough concentrations were included in the longitudinal data analysis. This analysis showed that inflammation, reflected by CRP concentrations, significantly influenced the metabolic ratio, voriconazole trough concentration and voriconazole-N-oxide concentration (all P < 0.001), when corrected for other factors that could influence voriconazole metabolism. The metabolic ratio was decreased by 0.99229N and the voriconazole-N-oxide concentration by 0.99775N, while the voriconazole trough concentration was increased by 1.005321N, where N is the difference in CRP units (in mg/L).This study shows that voriconazole metabolism is decreased during inflammation, resulting in higher voriconazole trough concentrations. Therefore, frequent monitoring of voriconazole serum concentrations is recommended during and following severe inflammation." @default.
• W2508431504 created "2016-09-16" @default.
• W2508431504 creator A5000820066 @default.
• W2508431504 creator A5003744221 @default.
• W2508431504 creator A5003929307 @default.
• W2508431504 creator A5018163150 @default.
• W2508431504 creator A5032436027 @default.
• W2508431504 creator A5049690412 @default.
• W2508431504 creator A5052959441 @default.
• W2508431504 creator A5060465721 @default.
• W2508431504 creator A5087697755 @default.
• W2508431504 date "2016-09-06" @default.
• W2508431504 modified "2023-10-16" @default.
• W2508431504 title "Voriconazole metabolism is influenced by severe inflammation: a prospective study" @default.
• W2508431504 cites W101668356 @default.
• W2508431504 cites W1768679997 @default.
• W2508431504 cites W1890388819 @default.
• W2508431504 cites W2015870178 @default.
• W2508431504 cites W2016465981 @default.
• W2508431504 cites W2031785695 @default.
• W2508431504 cites W2035610264 @default.
• W2508431504 cites W2036323185 @default.
• W2508431504 cites W2044634578 @default.
• W2508431504 cites W2051816101 @default.
• W2508431504 cites W2054565825 @default.
• W2508431504 cites W2063905878 @default.
• W2508431504 cites W2071524497 @default.
• W2508431504 cites W2071582918 @default.
• W2508431504 cites W2081558811 @default.
• W2508431504 cites W2097124667 @default.
• W2508431504 cites W2101089712 @default.
• W2508431504 cites W2103641008 @default.
• W2508431504 cites W2104880893 @default.
• W2508431504 cites W2108102291 @default.
• W2508431504 cites W2112271094 @default.
• W2508431504 cites W2116635252 @default.
• W2508431504 cites W2121237805 @default.
• W2508431504 cites W2123134253 @default.
• W2508431504 cites W2126153244 @default.
• W2508431504 cites W2130328040 @default.
• W2508431504 cites W2139365607 @default.
• W2508431504 cites W2148605276 @default.
• W2508431504 cites W2149095487 @default.
• W2508431504 cites W2149613723 @default.
• W2508431504 cites W2149640380 @default.
• W2508431504 cites W2162857158 @default.
• W2508431504 cites W2165158988 @default.
• W2508431504 cites W2165405846 @default.
• W2508431504 cites W2253099550 @default.
• W2508431504 cites W2285757988 @default.
• W2508431504 cites W2317184793 @default.
• W2508431504 cites W2490208522 @default.
• W2508431504 cites W4237615604 @default.
• W2508431504 cites W572885427 @default.
• W2508431504 doi "https://doi.org/10.1093/jac/dkw349" @default.
• W2508431504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27601292" @default.
• W2508431504 hasPublicationYear "2016" @default.
• W2508431504 type Work @default.
• W2508431504 sameAs 2508431504 @default.
• W2508431504 citedByCount "108" @default.
• W2508431504 countsByYear W25084315042017 @default.
• W2508431504 countsByYear W25084315042018 @default.
• W2508431504 countsByYear W25084315042019 @default.
• W2508431504 countsByYear W25084315042020 @default.
• W2508431504 countsByYear W25084315042021 @default.
• W2508431504 countsByYear W25084315042022 @default.
• W2508431504 countsByYear W25084315042023 @default.
• W2508431504 crossrefType "journal-article" @default.
• W2508431504 hasAuthorship W2508431504A5000820066 @default.
• W2508431504 hasAuthorship W2508431504A5003744221 @default.
• W2508431504 hasAuthorship W2508431504A5003929307 @default.
• W2508431504 hasAuthorship W2508431504A5018163150 @default.
• W2508431504 hasAuthorship W2508431504A5032436027 @default.
• W2508431504 hasAuthorship W2508431504A5049690412 @default.
• W2508431504 hasAuthorship W2508431504A5052959441 @default.
• W2508431504 hasAuthorship W2508431504A5060465721 @default.
• W2508431504 hasAuthorship W2508431504A5087697755 @default.
• W2508431504 hasBestOaLocation W25084315041 @default.
• W2508431504 hasConcept C112705442 @default.
• W2508431504 hasConcept C126322002 @default.
• W2508431504 hasConcept C16005928 @default.
• W2508431504 hasConcept C185592680 @default.
• W2508431504 hasConcept C2776914184 @default.
• W2508431504 hasConcept C2779548794 @default.
• W2508431504 hasConcept C2780690907 @default.
• W2508431504 hasConcept C2910800852 @default.
• W2508431504 hasConcept C71924100 @default.
• W2508431504 hasConcept C90924648 @default.
• W2508431504 hasConcept C98274493 @default.
• W2508431504 hasConceptScore W2508431504C112705442 @default.
• W2508431504 hasConceptScore W2508431504C126322002 @default.
• W2508431504 hasConceptScore W2508431504C16005928 @default.
• W2508431504 hasConceptScore W2508431504C185592680 @default.
• W2508431504 hasConceptScore W2508431504C2776914184 @default.
• W2508431504 hasConceptScore W2508431504C2779548794 @default.
• W2508431504 hasConceptScore W2508431504C2780690907 @default.
• W2508431504 hasConceptScore W2508431504C2910800852 @default.
• W2508431504 hasConceptScore W2508431504C71924100 @default.

• next