FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2508438596> ?p ?o ?g. }

• W2508438596 endingPage "1544" @default.
• W2508438596 startingPage "1536" @default.
• W2508438596 abstract "A major challenge in early treatment of acute cardiorenal syndrome (CRS) is the lack of predictors for progression of AKI. We aim to investigate the utility of urinary angiotensinogen and other renal injury biomarkers in predicting AKI progression in CRS.In this prospective, multicenter study, we screened 732 adults who admitted for acute decompensated heart failure from September 2011 to December 2014, and evaluated whether renal injury biomarkers measured at time of AKI diagnosis can predict worsening of AKI. In 213 patients who developed Kidney Disease Improving Global Outcomes stage 1 or 2 AKI, six renal injury biomarkers, including urinary angiotensinogen (uAGT), urinary neutrophil gelatinase-associated lipocalin (uNGAL), plasma neutrophil gelatinase-associated lipocalin, urinary IL-18 (uIL-18), urinary kidney injury molecule-1, and urinary albumin-to-creatinine ratio, were measured at time of AKI diagnosis. The primary outcome was AKI progression defined by worsening of AKI stage (50 patients). The secondary outcome was AKI progression with subsequent death (18 patients).After multivariable adjustment, the highest tertile of three urinary biomarkers remained associated with AKI progression compared with the lowest tertile: uAGT (odds ratio [OR], 10.8; 95% confidence interval [95% CI], 3.4 to 34.7), uNGAL (OR, 4.7; 95% CI, 1.7 to 13.4), and uIL-18 (OR, 3.6; 95% CI, 1.4 to 9.5). uAGT was the best predictor for both primary and secondary outcomes with area under the receiver operating curve of 0.78 and 0.85. These three biomarkers improved risk reclassification compared with the clinical model alone, with uAGT performing the best (category-free net reclassification improvement for primary and secondary outcomes of 0.76 [95% CI, 0.46 to 1.06] and 0.93 [95% CI, 0.50 to 1.36]; P<0.001). Excellent performance of uAGT was further confirmed with bootstrap internal validation.uAGT, uNGAL, and uIL-18 measured at time of AKI diagnosis improved risk stratification and identified CRS patients at highest risk of adverse outcomes." @default.
• W2508438596 created "2016-09-16" @default.
• W2508438596 creator A5003449723 @default.
• W2508438596 creator A5011723711 @default.
• W2508438596 creator A5012491543 @default.
• W2508438596 creator A5018802311 @default.
• W2508438596 creator A5025161064 @default.
• W2508438596 creator A5034964067 @default.
• W2508438596 creator A5045479938 @default.
• W2508438596 creator A5047455796 @default.
• W2508438596 creator A5061764811 @default.
• W2508438596 creator A5088893226 @default.
• W2508438596 date "2016-08-18" @default.
• W2508438596 modified "2023-10-14" @default.
• W2508438596 title "Urinary Biomarkers at the Time of AKI Diagnosis as Predictors of Progression of AKI among Patients with Acute Cardiorenal Syndrome" @default.
• W2508438596 cites W106281480 @default.
• W2508438596 cites W1489621351 @default.
• W2508438596 cites W1875039943 @default.
• W2508438596 cites W1969091056 @default.
• W2508438596 cites W1978867866 @default.
• W2508438596 cites W1993823264 @default.
• W2508438596 cites W2010385684 @default.
• W2508438596 cites W2012965629 @default.
• W2508438596 cites W2021907790 @default.
• W2508438596 cites W2026291621 @default.
• W2508438596 cites W2028597433 @default.
• W2508438596 cites W2032409670 @default.
• W2508438596 cites W2034705839 @default.
• W2508438596 cites W2077967941 @default.
• W2508438596 cites W2088741159 @default.
• W2508438596 cites W2092327037 @default.
• W2508438596 cites W2095475542 @default.
• W2508438596 cites W2102671199 @default.
• W2508438596 cites W2103205889 @default.
• W2508438596 cites W2104305817 @default.
• W2508438596 cites W2112316706 @default.
• W2508438596 cites W2113313693 @default.
• W2508438596 cites W2115560634 @default.
• W2508438596 cites W2117440871 @default.
• W2508438596 cites W2119976730 @default.
• W2508438596 cites W2130644475 @default.
• W2508438596 cites W2137489859 @default.
• W2508438596 cites W2138721400 @default.
• W2508438596 cites W2142765620 @default.
• W2508438596 cites W2145506399 @default.
• W2508438596 cites W2155965977 @default.
• W2508438596 cites W2157214848 @default.
• W2508438596 cites W2157871994 @default.
• W2508438596 cites W2159578467 @default.
• W2508438596 cites W2170433159 @default.
• W2508438596 cites W2408374451 @default.
• W2508438596 cites W2418288050 @default.
• W2508438596 cites W2912227678 @default.
• W2508438596 cites W3106889297 @default.
• W2508438596 doi "https://doi.org/10.2215/cjn.00910116" @default.
• W2508438596 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5012473" @default.
• W2508438596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27538426" @default.
• W2508438596 hasPublicationYear "2016" @default.
• W2508438596 type Work @default.
• W2508438596 sameAs 2508438596 @default.
• W2508438596 citedByCount "65" @default.
• W2508438596 countsByYear W25084385962016 @default.
• W2508438596 countsByYear W25084385962017 @default.
• W2508438596 countsByYear W25084385962018 @default.
• W2508438596 countsByYear W25084385962019 @default.
• W2508438596 countsByYear W25084385962020 @default.
• W2508438596 countsByYear W25084385962021 @default.
• W2508438596 countsByYear W25084385962022 @default.
• W2508438596 countsByYear W25084385962023 @default.
• W2508438596 crossrefType "journal-article" @default.
• W2508438596 hasAuthorship W2508438596A5003449723 @default.
• W2508438596 hasAuthorship W2508438596A5011723711 @default.
• W2508438596 hasAuthorship W2508438596A5012491543 @default.
• W2508438596 hasAuthorship W2508438596A5018802311 @default.
• W2508438596 hasAuthorship W2508438596A5025161064 @default.
• W2508438596 hasAuthorship W2508438596A5034964067 @default.
• W2508438596 hasAuthorship W2508438596A5045479938 @default.
• W2508438596 hasAuthorship W2508438596A5047455796 @default.
• W2508438596 hasAuthorship W2508438596A5061764811 @default.
• W2508438596 hasAuthorship W2508438596A5088893226 @default.
• W2508438596 hasBestOaLocation W25084385961 @default.
• W2508438596 hasConcept C126322002 @default.
• W2508438596 hasConcept C156957248 @default.
• W2508438596 hasConcept C20299238 @default.
• W2508438596 hasConcept C2778653478 @default.
• W2508438596 hasConcept C2780306776 @default.
• W2508438596 hasConcept C2780472472 @default.
• W2508438596 hasConcept C2781309322 @default.
• W2508438596 hasConcept C71924100 @default.
• W2508438596 hasConcept C77411442 @default.
• W2508438596 hasConcept C90924648 @default.
• W2508438596 hasConceptScore W2508438596C126322002 @default.
• W2508438596 hasConceptScore W2508438596C156957248 @default.
• W2508438596 hasConceptScore W2508438596C20299238 @default.
• W2508438596 hasConceptScore W2508438596C2778653478 @default.
• W2508438596 hasConceptScore W2508438596C2780306776 @default.
• W2508438596 hasConceptScore W2508438596C2780472472 @default.
• W2508438596 hasConceptScore W2508438596C2781309322 @default.

• next