FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2508614063> ?p ?o ?g. }

• W2508614063 abstract "Streptococcus pyogenes, or group A Streptococcus (GAS), is a human bacterial pathogen that can manifest as a range of diseases from pharyngitis and impetigo to severe outcomes such as necrotizing fasciitis and toxic shock syndrome. GAS disease remains a global health burden with cases estimated at over 700 million annually and over half a million deaths due to severe infections1. For over 100 years, a clinical hallmark of diagnosis has been the appearance of complete (beta) haemolysis when grown in the presence of blood. This activity is due to the production of a small peptide toxin by GAS known as streptolysin S. Although it has been widely held that streptolysin S exerts its lytic activity through membrane disruption, its exact mode of action has remained unknown. Here, we show, using high-resolution live cell imaging, that streptolysin S induces a dramatic osmotic change in red blood cells, leading to cell lysis. This osmotic change was characterized by the rapid influx of Cl− ions into the red blood cells through SLS-mediated disruption of the major erythrocyte anion exchange protein, band 3. Chemical inhibition of band 3 function significantly reduced the haemolytic activity of streptolysin S, and dramatically reduced the pathology in an in vivo skin model of GAS infection. These results provide key insights into the mechanism of streptolysin S-mediated haemolysis and have implications for the development of treatments against GAS. Streptococcus pyogenes (also known as group A Streptococcus or GAS) streptolysin S (SLS)-mediated red blood cell lysis occurs through disruption of the function of major erythrocyte anion exchange protein, band 3, leading to Cl- ion influx." @default.
• W2508614063 created "2016-09-16" @default.
• W2508614063 creator A5019501202 @default.
• W2508614063 creator A5019533861 @default.
• W2508614063 creator A5020583147 @default.
• W2508614063 creator A5031035805 @default.
• W2508614063 creator A5040088798 @default.
• W2508614063 creator A5044664283 @default.
• W2508614063 creator A5049318806 @default.
• W2508614063 creator A5050593261 @default.
• W2508614063 creator A5068045807 @default.
• W2508614063 creator A5069819135 @default.
• W2508614063 creator A5074871163 @default.
• W2508614063 date "2016-01-18" @default.
• W2508614063 modified "2023-10-17" @default.
• W2508614063 title "Activation of band 3 mediates group A Streptococcus streptolysin S-based beta-haemolysis" @default.
• W2508614063 cites W1011784912 @default.
• W2508614063 cites W1524550442 @default.
• W2508614063 cites W1819300770 @default.
• W2508614063 cites W1954606512 @default.
• W2508614063 cites W1965730980 @default.
• W2508614063 cites W1988056003 @default.
• W2508614063 cites W1988697869 @default.
• W2508614063 cites W2000520621 @default.
• W2508614063 cites W2005309431 @default.
• W2508614063 cites W2021762682 @default.
• W2508614063 cites W2024698360 @default.
• W2508614063 cites W2026838076 @default.
• W2508614063 cites W2039523665 @default.
• W2508614063 cites W2045338471 @default.
• W2508614063 cites W2053819820 @default.
• W2508614063 cites W2058656568 @default.
• W2508614063 cites W2063492068 @default.
• W2508614063 cites W2073406311 @default.
• W2508614063 cites W2073879684 @default.
• W2508614063 cites W2084355320 @default.
• W2508614063 cites W2084552689 @default.
• W2508614063 cites W2107429021 @default.
• W2508614063 cites W2119609891 @default.
• W2508614063 cites W2120656564 @default.
• W2508614063 cites W2125254733 @default.
• W2508614063 cites W2131014711 @default.
• W2508614063 cites W2136900732 @default.
• W2508614063 cites W2144017255 @default.
• W2508614063 cites W2144530802 @default.
• W2508614063 cites W2163167849 @default.
• W2508614063 cites W2171780167 @default.
• W2508614063 cites W2181153785 @default.
• W2508614063 doi "https://doi.org/10.1038/nmicrobiol.2015.4" @default.
• W2508614063 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27571972" @default.
• W2508614063 hasPublicationYear "2016" @default.
• W2508614063 type Work @default.
• W2508614063 sameAs 2508614063 @default.
• W2508614063 citedByCount "21" @default.
• W2508614063 countsByYear W25086140632017 @default.
• W2508614063 countsByYear W25086140632018 @default.
• W2508614063 countsByYear W25086140632019 @default.
• W2508614063 countsByYear W25086140632020 @default.
• W2508614063 countsByYear W25086140632021 @default.
• W2508614063 countsByYear W25086140632022 @default.
• W2508614063 countsByYear W25086140632023 @default.
• W2508614063 crossrefType "journal-article" @default.
• W2508614063 hasAuthorship W2508614063A5019501202 @default.
• W2508614063 hasAuthorship W2508614063A5019533861 @default.
• W2508614063 hasAuthorship W2508614063A5020583147 @default.
• W2508614063 hasAuthorship W2508614063A5031035805 @default.
• W2508614063 hasAuthorship W2508614063A5040088798 @default.
• W2508614063 hasAuthorship W2508614063A5044664283 @default.
• W2508614063 hasAuthorship W2508614063A5049318806 @default.
• W2508614063 hasAuthorship W2508614063A5050593261 @default.
• W2508614063 hasAuthorship W2508614063A5068045807 @default.
• W2508614063 hasAuthorship W2508614063A5069819135 @default.
• W2508614063 hasAuthorship W2508614063A5074871163 @default.
• W2508614063 hasConcept C104317684 @default.
• W2508614063 hasConcept C126322002 @default.
• W2508614063 hasConcept C154317977 @default.
• W2508614063 hasConcept C185592680 @default.
• W2508614063 hasConcept C202751555 @default.
• W2508614063 hasConcept C203014093 @default.
• W2508614063 hasConcept C2776993315 @default.
• W2508614063 hasConcept C2778276568 @default.
• W2508614063 hasConcept C2778811088 @default.
• W2508614063 hasConcept C2779306812 @default.
• W2508614063 hasConcept C2779489039 @default.
• W2508614063 hasConcept C2779902561 @default.
• W2508614063 hasConcept C2780678043 @default.
• W2508614063 hasConcept C2910801743 @default.
• W2508614063 hasConcept C2993175405 @default.
• W2508614063 hasConcept C523546767 @default.
• W2508614063 hasConcept C54355233 @default.
• W2508614063 hasConcept C55493867 @default.
• W2508614063 hasConcept C60987743 @default.
• W2508614063 hasConcept C71924100 @default.
• W2508614063 hasConcept C73588182 @default.
• W2508614063 hasConcept C80595800 @default.
• W2508614063 hasConcept C86803240 @default.
• W2508614063 hasConcept C89423630 @default.
• W2508614063 hasConceptScore W2508614063C104317684 @default.
• W2508614063 hasConceptScore W2508614063C126322002 @default.
• W2508614063 hasConceptScore W2508614063C154317977 @default.

• next