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- W2508746147 abstract "Natural selection should be studied as an edd in itself, and this requires rigorous e qerimental tests of theoretical models linking molecular phenotypes to differences irr fitness. We describe the experimental ckfication of one such model and there6y demonstrate that the causal relations between genotype and fitness need not be as hopelessly complex as many have assumed. The model uses metabolic control theory to link enzyme activity to metabolic flux and then assumes that fitness is proportional to flux. The model was tested using the pathlcay for the uptake and metabolism o. growth-rate-limiting concentrations of Ioctose in E. co/i inha6iting chemostats. hlany of the properties expected of natural sc>lection are manifest in this system. _. Only two questions can be asked about natural selection: what are its causes and what are its effects? The laws of population and quantitative genetics describe the effects of natural selection and are usually invoked when demonstrating the actlon of natural selection in nature’. These laws are called ‘consequence laws’, to distinguish them from the ‘y;ource laws’ that determine the causes of natural selection*. Attempts to delineate these source" @default.
- W2508746147 created "2016-09-16" @default.
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- W2508746147 date "1990-01-01" @default.
- W2508746147 modified "2023-09-27" @default.
- W2508746147 title "Enzyme Activity and Fitness" @default.
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