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- W2509007249 abstract "One possibility to optimize the therapeutic application of dopaminergic compounds with a catechol function is the reversible protection of this moiety using a prodrug approach. Important features in this respect are a proper chemical stability in the gastrointestinal tract, an adequate release rate after arrival in the blood stream or the possibility to cross the blood-brain barrier. A HPLC method was developed to measure the hydrolysis of prodrugs of dopamine and epinine directly, The method is based on reversed-phase separation followed by post-column ion-pair extraction with a fluorescent counter-ion, The separation of di-isobutyryl esters of dopamine and epinine is obtained within 10 min while the more hydrophobic dopaminergic esters, di-benzoyl and di-pivaloyl dopamine, are retained for 30 min. The precision of the assay measuring 160 ng dibudop and 100 ng ibopamine was 1.2 and 1.0% respectively. The detection limit of all prodrugs tested was approximately 1O ng." @default.
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- W2509007249 date "1997-06-06" @default.
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- W2509007249 title "Determination of dopaminergic prodrugs by high-performance liquid chromatography followed by post-column ion-pair extraction" @default.
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