Matches in SemOpenAlex for { <https://semopenalex.org/work/W2509013293> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2509013293 endingPage "6539" @default.
- W2509013293 startingPage "6539" @default.
- W2509013293 abstract "6539 Background: Disease relapse is a major cause of treatment failure after allogeneic HCT for AML and MDS. Therapeutic options after relapse are limited and the prognosis remains dismal. Methods: We analyzed 245 patients who received allogeneic HCT for MDS/AML using the conditioning regimen of fludarabine 40 mg/m2 and busulfan 130 mg/m2 for four days, between April 2001 and June 2008: 88 patients recurred. Results: Median age was 45 (range:18-66) years. Diagnosis was AML (n=72; 82%) or MDS (n=16; 18%). Donors were related (n=56) or unrelated (n=32). Relapse treatment: 21% (N=18) received supportive care only while 76% (N=67) received salvage (3 patients were lost to follow-up). Median complete remission (CR) duration after first HCT for the recurred group was 4 months; 67% of the patients relapsing <4 months received salvage treatment versus 90% of those that relapsed in >4 months (p=0.02). Salvage included: chemotherapy only (N=31), donor lymphocyte infusion (DLI) with or without chemotherapy (N=11), other (N=3), and second HCT with or without preceding salvage chemotherapy (n=22; 25%). Disease status at second HCT: CR2 (n=5) or active disease (n=17). Median survival after relapse was 3 months; 9 patients are alive (10%; 7 of 9 received second HCT. 2-year over all survival (OS) for second HCT and chemotherapy groups was 45% and 10%, respectively. Whereas 2-year OS was 0% for both DLI and supportive care only group. One-year OS was 45% (N=43) versus 10% (N=45) for patients whose post-transplant remission lasted >4 and <4 months, respectively (P=0.009). Conclusions: Survival after relapse is dictated primarily by post-transplant remission duration. A second HCT holds promise for long-term disease control in a subset of patients. 2-year OS 2-year OS Second allogeneic HCT 45% Chemotherapy 10% Donor lymphocyte infusion (DLI) 0% Supportive care only 0% CR duration after 1st HCT 1-year OS > 4 mo 45% < 4 mo 10% ü(p=0.009) No significant financial relationships to disclose." @default.
- W2509013293 created "2016-09-16" @default.
- W2509013293 creator A5029237145 @default.
- W2509013293 creator A5030208423 @default.
- W2509013293 creator A5030539313 @default.
- W2509013293 creator A5034264716 @default.
- W2509013293 creator A5035482350 @default.
- W2509013293 creator A5048937313 @default.
- W2509013293 creator A5065787605 @default.
- W2509013293 creator A5067807357 @default.
- W2509013293 creator A5068834306 @default.
- W2509013293 creator A5091453183 @default.
- W2509013293 date "2010-05-20" @default.
- W2509013293 modified "2023-09-27" @default.
- W2509013293 title "Treatment of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) relapsing after allogeneic hematopoietic cell transplantation (HCT)." @default.
- W2509013293 doi "https://doi.org/10.1200/jco.2010.28.15_suppl.6539" @default.
- W2509013293 hasPublicationYear "2010" @default.
- W2509013293 type Work @default.
- W2509013293 sameAs 2509013293 @default.
- W2509013293 citedByCount "0" @default.
- W2509013293 crossrefType "journal-article" @default.
- W2509013293 hasAuthorship W2509013293A5029237145 @default.
- W2509013293 hasAuthorship W2509013293A5030208423 @default.
- W2509013293 hasAuthorship W2509013293A5030539313 @default.
- W2509013293 hasAuthorship W2509013293A5034264716 @default.
- W2509013293 hasAuthorship W2509013293A5035482350 @default.
- W2509013293 hasAuthorship W2509013293A5048937313 @default.
- W2509013293 hasAuthorship W2509013293A5065787605 @default.
- W2509013293 hasAuthorship W2509013293A5067807357 @default.
- W2509013293 hasAuthorship W2509013293A5068834306 @default.
- W2509013293 hasAuthorship W2509013293A5091453183 @default.
- W2509013293 hasConcept C126322002 @default.
- W2509013293 hasConcept C141071460 @default.
- W2509013293 hasConcept C2776694085 @default.
- W2509013293 hasConcept C2776755627 @default.
- W2509013293 hasConcept C2777408962 @default.
- W2509013293 hasConcept C2778336483 @default.
- W2509013293 hasConcept C2779263901 @default.
- W2509013293 hasConcept C2779695342 @default.
- W2509013293 hasConcept C2780611847 @default.
- W2509013293 hasConcept C2780775027 @default.
- W2509013293 hasConcept C2781413609 @default.
- W2509013293 hasConcept C2911091166 @default.
- W2509013293 hasConcept C71924100 @default.
- W2509013293 hasConcept C90924648 @default.
- W2509013293 hasConceptScore W2509013293C126322002 @default.
- W2509013293 hasConceptScore W2509013293C141071460 @default.
- W2509013293 hasConceptScore W2509013293C2776694085 @default.
- W2509013293 hasConceptScore W2509013293C2776755627 @default.
- W2509013293 hasConceptScore W2509013293C2777408962 @default.
- W2509013293 hasConceptScore W2509013293C2778336483 @default.
- W2509013293 hasConceptScore W2509013293C2779263901 @default.
- W2509013293 hasConceptScore W2509013293C2779695342 @default.
- W2509013293 hasConceptScore W2509013293C2780611847 @default.
- W2509013293 hasConceptScore W2509013293C2780775027 @default.
- W2509013293 hasConceptScore W2509013293C2781413609 @default.
- W2509013293 hasConceptScore W2509013293C2911091166 @default.
- W2509013293 hasConceptScore W2509013293C71924100 @default.
- W2509013293 hasConceptScore W2509013293C90924648 @default.
- W2509013293 hasIssue "15_suppl" @default.
- W2509013293 hasLocation W25090132931 @default.
- W2509013293 hasOpenAccess W2509013293 @default.
- W2509013293 hasPrimaryLocation W25090132931 @default.
- W2509013293 hasRelatedWork W1955322177 @default.
- W2509013293 hasRelatedWork W1995560966 @default.
- W2509013293 hasRelatedWork W2060940696 @default.
- W2509013293 hasRelatedWork W2069306963 @default.
- W2509013293 hasRelatedWork W2088035700 @default.
- W2509013293 hasRelatedWork W2360634842 @default.
- W2509013293 hasRelatedWork W2405138071 @default.
- W2509013293 hasRelatedWork W2509013293 @default.
- W2509013293 hasRelatedWork W3002680405 @default.
- W2509013293 hasRelatedWork W3174720739 @default.
- W2509013293 hasVolume "28" @default.
- W2509013293 isParatext "false" @default.
- W2509013293 isRetracted "false" @default.
- W2509013293 magId "2509013293" @default.
- W2509013293 workType "article" @default.