FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2509038704> ?p ?o ?g. }

• W2509038704 endingPage "1226" @default.
• W2509038704 startingPage "1220" @default.
• W2509038704 abstract "The contribution of long non-coding RNAs (lncRNAs) to tumorigenesis and metastasis of pancreatic cancer (PC) remains largely unknown. Urothelial cancer-associated 1 (UCA1), which is an originally identified lncRNA in bladder cancer, has be proved to play a pivotal role in bladder cancer progression and embryonic development. In this study, we detected the mRNA expression of UCA1 in 128 PC patients by qRT-PCR, and found that UCA1 expression was significantly, up-regulated in tumor tissues than that in matched adjacent non-tumor tissues (p<0.05). Clinicopathological analysis demonstrated that UCA1 expression in PC significantly correlated with malignant potential factors such as tumor size (p=0.021), depth of invasion (p=0.033), CA19-9 level (p=0.034) and tumor stage (p=0.013). Cox proportional hazards regression analysis also confirmed that high UCA1 expression was an independent prognostic biomarker of PC (p=0.046), which led to an obviously shorter 5-year overall survival (OS) compared to those patients with low UCA1 expressions (p=0.018). Furthermore, we effectively down-regulated UCA1 mRNA expression by transfecting RNA interfere fragments into SW-1990 cells, and our results in vitro indicated that down-regulation of UCA1 could effectively inhibit the cell proliferative activities, induce apoptotic rate and cause cell cycle arrest in PC cells (p<0.05). Meanwhile, UCA1 expression negative-correlated with p27 in PC tissues (r2=0.46, p<0.01), and knockdown of p27 partly abrogated the cell proliferative activities caused by UCA1 (p<0.05). Our results raised the possibility of using UCA1 as a potential prognostic biomarker and therapy target of PC, and down-regulation of UCA1 might be considered to be a novel molecular treatment strategy for patients with PC." @default.
• W2509038704 created "2016-09-16" @default.
• W2509038704 creator A5011040894 @default.
• W2509038704 creator A5016332039 @default.
• W2509038704 creator A5031829937 @default.
• W2509038704 creator A5034329447 @default.
• W2509038704 creator A5050439687 @default.
• W2509038704 creator A5071545452 @default.
• W2509038704 date "2016-10-01" @default.
• W2509038704 modified "2023-10-05" @default.
• W2509038704 title "Long non-coding RNA UCA1 promotes the tumorigenesis in pancreatic cancer" @default.
• W2509038704 cites W1539551850 @default.
• W2509038704 cites W1615726156 @default.
• W2509038704 cites W1971997781 @default.
• W2509038704 cites W1986178550 @default.
• W2509038704 cites W1996207018 @default.
• W2509038704 cites W2006467468 @default.
• W2509038704 cites W2007942290 @default.
• W2509038704 cites W2012020865 @default.
• W2509038704 cites W2018005623 @default.
• W2509038704 cites W2028441878 @default.
• W2509038704 cites W2046381665 @default.
• W2509038704 cites W2049818912 @default.
• W2509038704 cites W2062083667 @default.
• W2509038704 cites W2071040214 @default.
• W2509038704 cites W2078526959 @default.
• W2509038704 cites W2099772080 @default.
• W2509038704 cites W2105592429 @default.
• W2509038704 cites W2107277218 @default.
• W2509038704 cites W2109306765 @default.
• W2509038704 cites W2126246937 @default.
• W2509038704 cites W2137226828 @default.
• W2509038704 cites W2164346983 @default.
• W2509038704 cites W2169961966 @default.
• W2509038704 cites W623874819 @default.
• W2509038704 doi "https://doi.org/10.1016/j.biopha.2016.08.041" @default.
• W2509038704 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27562722" @default.
• W2509038704 hasPublicationYear "2016" @default.
• W2509038704 type Work @default.
• W2509038704 sameAs 2509038704 @default.
• W2509038704 citedByCount "66" @default.
• W2509038704 countsByYear W25090387042017 @default.
• W2509038704 countsByYear W25090387042018 @default.
• W2509038704 countsByYear W25090387042019 @default.
• W2509038704 countsByYear W25090387042020 @default.
• W2509038704 countsByYear W25090387042021 @default.
• W2509038704 countsByYear W25090387042022 @default.
• W2509038704 countsByYear W25090387042023 @default.
• W2509038704 crossrefType "journal-article" @default.
• W2509038704 hasAuthorship W2509038704A5011040894 @default.
• W2509038704 hasAuthorship W2509038704A5016332039 @default.
• W2509038704 hasAuthorship W2509038704A5031829937 @default.
• W2509038704 hasAuthorship W2509038704A5034329447 @default.
• W2509038704 hasAuthorship W2509038704A5050439687 @default.
• W2509038704 hasAuthorship W2509038704A5071545452 @default.
• W2509038704 hasConcept C104317684 @default.
• W2509038704 hasConcept C105580179 @default.
• W2509038704 hasConcept C121608353 @default.
• W2509038704 hasConcept C126322002 @default.
• W2509038704 hasConcept C173396325 @default.
• W2509038704 hasConcept C190283241 @default.
• W2509038704 hasConcept C2779013556 @default.
• W2509038704 hasConcept C2780210213 @default.
• W2509038704 hasConcept C2780352672 @default.
• W2509038704 hasConcept C2781197716 @default.
• W2509038704 hasConcept C29537977 @default.
• W2509038704 hasConcept C502942594 @default.
• W2509038704 hasConcept C54355233 @default.
• W2509038704 hasConcept C55493867 @default.
• W2509038704 hasConcept C555283112 @default.
• W2509038704 hasConcept C62112901 @default.
• W2509038704 hasConcept C62203573 @default.
• W2509038704 hasConcept C67705224 @default.
• W2509038704 hasConcept C71924100 @default.
• W2509038704 hasConcept C86803240 @default.
• W2509038704 hasConceptScore W2509038704C104317684 @default.
• W2509038704 hasConceptScore W2509038704C105580179 @default.
• W2509038704 hasConceptScore W2509038704C121608353 @default.
• W2509038704 hasConceptScore W2509038704C126322002 @default.
• W2509038704 hasConceptScore W2509038704C173396325 @default.
• W2509038704 hasConceptScore W2509038704C190283241 @default.
• W2509038704 hasConceptScore W2509038704C2779013556 @default.
• W2509038704 hasConceptScore W2509038704C2780210213 @default.
• W2509038704 hasConceptScore W2509038704C2780352672 @default.
• W2509038704 hasConceptScore W2509038704C2781197716 @default.
• W2509038704 hasConceptScore W2509038704C29537977 @default.
• W2509038704 hasConceptScore W2509038704C502942594 @default.
• W2509038704 hasConceptScore W2509038704C54355233 @default.
• W2509038704 hasConceptScore W2509038704C55493867 @default.
• W2509038704 hasConceptScore W2509038704C555283112 @default.
• W2509038704 hasConceptScore W2509038704C62112901 @default.
• W2509038704 hasConceptScore W2509038704C62203573 @default.
• W2509038704 hasConceptScore W2509038704C67705224 @default.
• W2509038704 hasConceptScore W2509038704C71924100 @default.
• W2509038704 hasConceptScore W2509038704C86803240 @default.
• W2509038704 hasLocation W25090387041 @default.
• W2509038704 hasLocation W25090387042 @default.
• W2509038704 hasOpenAccess W2509038704 @default.

• next