Matches in SemOpenAlex for { <https://semopenalex.org/work/W2509177524> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2509177524 abstract "Taipei Medical University, Taiwan A proliferation of vascular smooth muscle cells (VSMCs) play important roles in the development of cardiovascular diseases. PMC (2,2,5,7,8-pentamethyl6-hydroxychromane) is the most potent hydrophilic derivative of the vitamin E. In this study, we investigated the inhibitory mechanisms of PMC on VSMC proliferation in vitro and in vivo. PMC (20 and 50 μM) obviously suppressed cell proliferation of PDGF-BB-stimulated cells but not resting cells, and arrested cell cycle progression at the G2/M phase. A signifi cant reduction of neointimal formation in carotid arteries was observed in PMC (5 mg/kg/day)-treated rats aft er balloon angioplasty. Activations of STAT3, JAK2, PLCγ1, PKCδ, and ROS, but not ERK1/2, AKT, or PKCα, were markedly inhibited by PMC in PDGF-BB-stimulated VSMCs. Deferoxamine and PMC signifi cantly inhibited the phosphorylation of PLCγ1 and JAK2 and arrested cell cycle progression at the G2/M phase. Th ese events, however, were reversed in the presence of Fe2+. Moreover, PMC directly inhibited hydroxyl radical formation in both the Fenton reaction and VSMCs according to an electron spin resonance study. In conclusion, this study demonstrates for the fi rst time that PMC inhibited VSMC proliferation in vitro, and balloon injury-induced neointimal formation in vivo. Th e inhibitory mechanisms of PMC may be involved in the inhibition of hydroxyl radicalmediated PLCγ1-PKCδ and JAK2-STAT3 activation, and causes cell cycle arrest at the G2/M phase. PMC treatment may represent a novel approach for lowering the risk of or improving the function in abnormal VSMC proliferation-related vascular diseases." @default.
- W2509177524 created "2016-09-16" @default.
- W2509177524 creator A5049989912 @default.
- W2509177524 date "2013-07-15" @default.
- W2509177524 modified "2023-09-24" @default.
- W2509177524 title "Inhibition of vascular smooth muscle cell proliferation of Vitamin E derivative Pentamethyl hydroxychromane" @default.
- W2509177524 hasPublicationYear "2013" @default.
- W2509177524 type Work @default.
- W2509177524 sameAs 2509177524 @default.
- W2509177524 citedByCount "0" @default.
- W2509177524 crossrefType "journal-article" @default.
- W2509177524 hasAuthorship W2509177524A5049989912 @default.
- W2509177524 hasConcept C126322002 @default.
- W2509177524 hasConcept C150903083 @default.
- W2509177524 hasConcept C170493617 @default.
- W2509177524 hasConcept C180361614 @default.
- W2509177524 hasConcept C185592680 @default.
- W2509177524 hasConcept C190283241 @default.
- W2509177524 hasConcept C202751555 @default.
- W2509177524 hasConcept C207001950 @default.
- W2509177524 hasConcept C2775960820 @default.
- W2509177524 hasConcept C2776672577 @default.
- W2509177524 hasConcept C2778923194 @default.
- W2509177524 hasConcept C2779395532 @default.
- W2509177524 hasConcept C29537977 @default.
- W2509177524 hasConcept C2992686903 @default.
- W2509177524 hasConcept C502942594 @default.
- W2509177524 hasConcept C55493867 @default.
- W2509177524 hasConcept C62112901 @default.
- W2509177524 hasConcept C71924100 @default.
- W2509177524 hasConcept C75217442 @default.
- W2509177524 hasConcept C86803240 @default.
- W2509177524 hasConcept C95444343 @default.
- W2509177524 hasConcept C98274493 @default.
- W2509177524 hasConceptScore W2509177524C126322002 @default.
- W2509177524 hasConceptScore W2509177524C150903083 @default.
- W2509177524 hasConceptScore W2509177524C170493617 @default.
- W2509177524 hasConceptScore W2509177524C180361614 @default.
- W2509177524 hasConceptScore W2509177524C185592680 @default.
- W2509177524 hasConceptScore W2509177524C190283241 @default.
- W2509177524 hasConceptScore W2509177524C202751555 @default.
- W2509177524 hasConceptScore W2509177524C207001950 @default.
- W2509177524 hasConceptScore W2509177524C2775960820 @default.
- W2509177524 hasConceptScore W2509177524C2776672577 @default.
- W2509177524 hasConceptScore W2509177524C2778923194 @default.
- W2509177524 hasConceptScore W2509177524C2779395532 @default.
- W2509177524 hasConceptScore W2509177524C29537977 @default.
- W2509177524 hasConceptScore W2509177524C2992686903 @default.
- W2509177524 hasConceptScore W2509177524C502942594 @default.
- W2509177524 hasConceptScore W2509177524C55493867 @default.
- W2509177524 hasConceptScore W2509177524C62112901 @default.
- W2509177524 hasConceptScore W2509177524C71924100 @default.
- W2509177524 hasConceptScore W2509177524C75217442 @default.
- W2509177524 hasConceptScore W2509177524C86803240 @default.
- W2509177524 hasConceptScore W2509177524C95444343 @default.
- W2509177524 hasConceptScore W2509177524C98274493 @default.
- W2509177524 hasLocation W25091775241 @default.
- W2509177524 hasOpenAccess W2509177524 @default.
- W2509177524 hasPrimaryLocation W25091775241 @default.
- W2509177524 hasRelatedWork W1026592741 @default.
- W2509177524 hasRelatedWork W1982422042 @default.
- W2509177524 hasRelatedWork W1996102407 @default.
- W2509177524 hasRelatedWork W2027304700 @default.
- W2509177524 hasRelatedWork W2041255837 @default.
- W2509177524 hasRelatedWork W2109910227 @default.
- W2509177524 hasRelatedWork W2113171186 @default.
- W2509177524 hasRelatedWork W2271441395 @default.
- W2509177524 hasRelatedWork W2290153393 @default.
- W2509177524 hasRelatedWork W2366936996 @default.
- W2509177524 hasRelatedWork W2405477459 @default.
- W2509177524 hasRelatedWork W2472968296 @default.
- W2509177524 hasRelatedWork W2600059493 @default.
- W2509177524 hasRelatedWork W31607730 @default.
- W2509177524 hasRelatedWork W3173715714 @default.
- W2509177524 hasRelatedWork W3198160935 @default.
- W2509177524 hasRelatedWork W338713796 @default.
- W2509177524 hasRelatedWork W339979645 @default.
- W2509177524 hasRelatedWork W638412426 @default.
- W2509177524 hasRelatedWork W3102234597 @default.
- W2509177524 isParatext "false" @default.
- W2509177524 isRetracted "false" @default.
- W2509177524 magId "2509177524" @default.
- W2509177524 workType "article" @default.