FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2509290464> ?p ?o ?g. }

• W2509290464 endingPage "152" @default.
• W2509290464 startingPage "138" @default.
• W2509290464 abstract "Background: Chronic HIV disease is associated with neurocognitive impairment and age-related conditions such as frailty. Objective: To determine whether regional brain volumetric changes correlate with frailty parameters in older (≥ 40 years) HIV+ patients on stable combination antiretroviral therapy. Method: Thirty-five HIV-infected participants in the Hawaii Aging with HIV Cohort - Cardiovascular Disease study underwent T1-weighted brain magnetic resonance imaging, frailty assessment and neuropsychological testing. Five physical frailty traits were assessed: low physical activity; exhaustion; unintentional weight loss; weak hand grip strength; slow walking speed. Linear regression quantified cross-sectional relationships of 12 brain regions to walking times and hand grip strength. Results: Participants were 50.6 ± 6.8 years old and 77% had undetectable plasma viral load. One subject was frail (possessing ≥ 3 frailty traits); 23% were pre-frail (1–2 frailty traits) and had worse composite learning and memory z-scores than did non-frail individuals ( p =0.06). Pre-frail or frail subjects had reduced hand grip strength relative to the non-frail group ( p =0.001). Longer walking times (slower gait) related independently to lower volumes of cerebellar white matter ( p <0.001, β=−0.6) and subcortical gray matter ( p <0.05, β=−0.30). Reduced thalamus volume was linked to weaker grip strength ( p < 0.05, β=0.4). Caudate volume was negatively associated with grip strength ( p <0.01, β=−0.5). Conclusion: Volumetric changes in cerebellar white matter and subcortical gray matter, brain regions involved in motor control and cognition, may be connected to frailty development in well-controlled HIV. Gait speed is particularly sensitive to white matter alterations and should be investigated as a predictor of frailty and brain atrophy in chronically infected patients." @default.
• W2509290464 created "2016-09-16" @default.
• W2509290464 creator A5026337679 @default.
• W2509290464 creator A5031947542 @default.
• W2509290464 creator A5047272214 @default.
• W2509290464 creator A5068589340 @default.
• W2509290464 creator A5069175003 @default.
• W2509290464 creator A5071692284 @default.
• W2509290464 creator A5072086085 @default.
• W2509290464 creator A5091124506 @default.
• W2509290464 date "2016-08-29" @default.
• W2509290464 modified "2023-09-26" @default.
• W2509290464 title "Frailty Characteristics in Chronic HIV Patients are Markers of White Matter Atrophy Independently of Age and Depressive Symptoms: A Pilot Study" @default.
• W2509290464 cites W1483299686 @default.
• W2509290464 cites W1519631919 @default.
• W2509290464 cites W1551029662 @default.
• W2509290464 cites W1584481215 @default.
• W2509290464 cites W1606270551 @default.
• W2509290464 cites W1845813830 @default.
• W2509290464 cites W1938453639 @default.
• W2509290464 cites W1964327350 @default.
• W2509290464 cites W1966821136 @default.
• W2509290464 cites W1967548282 @default.
• W2509290464 cites W1975412844 @default.
• W2509290464 cites W1978843018 @default.
• W2509290464 cites W1983302707 @default.
• W2509290464 cites W1988354245 @default.
• W2509290464 cites W1990481190 @default.
• W2509290464 cites W1992214067 @default.
• W2509290464 cites W1995916672 @default.
• W2509290464 cites W1999215283 @default.
• W2509290464 cites W1999501405 @default.
• W2509290464 cites W2004293194 @default.
• W2509290464 cites W2005101532 @default.
• W2509290464 cites W2005399470 @default.
• W2509290464 cites W2008339309 @default.
• W2509290464 cites W2015715875 @default.
• W2509290464 cites W2024087673 @default.
• W2509290464 cites W2024457446 @default.
• W2509290464 cites W2034784218 @default.
• W2509290464 cites W2045271086 @default.
• W2509290464 cites W2046458826 @default.
• W2509290464 cites W2046949039 @default.
• W2509290464 cites W2053934726 @default.
• W2509290464 cites W2054470549 @default.
• W2509290464 cites W2055557609 @default.
• W2509290464 cites W2060052647 @default.
• W2509290464 cites W2067495470 @default.
• W2509290464 cites W2071922584 @default.
• W2509290464 cites W2092569517 @default.
• W2509290464 cites W2099742817 @default.
• W2509290464 cites W2104284834 @default.
• W2509290464 cites W2110724572 @default.
• W2509290464 cites W2111446187 @default.
• W2509290464 cites W2112518510 @default.
• W2509290464 cites W2115118763 @default.
• W2509290464 cites W2115515636 @default.
• W2509290464 cites W2118432137 @default.
• W2509290464 cites W2119958965 @default.
• W2509290464 cites W2132750018 @default.
• W2509290464 cites W2135397849 @default.
• W2509290464 cites W2136162878 @default.
• W2509290464 cites W2142727674 @default.
• W2509290464 cites W2145677576 @default.
• W2509290464 cites W2149192059 @default.
• W2509290464 cites W2150521916 @default.
• W2509290464 cites W2151130155 @default.
• W2509290464 cites W2151721316 @default.
• W2509290464 cites W2157848968 @default.
• W2509290464 cites W2159296038 @default.
• W2509290464 cites W2160884592 @default.
• W2509290464 cites W2162308739 @default.
• W2509290464 cites W2164059021 @default.
• W2509290464 cites W2167898188 @default.
• W2509290464 cites W2240035754 @default.
• W2509290464 cites W2318289184 @default.
• W2509290464 cites W2321011045 @default.
• W2509290464 cites W2409110896 @default.
• W2509290464 cites W2416496664 @default.
• W2509290464 cites W2737966001 @default.
• W2509290464 doi "https://doi.org/10.2174/1874220301603010138" @default.
• W2509290464 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5051693" @default.
• W2509290464 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27721908" @default.
• W2509290464 hasPublicationYear "2016" @default.
• W2509290464 type Work @default.
• W2509290464 sameAs 2509290464 @default.
• W2509290464 citedByCount "14" @default.
• W2509290464 countsByYear W25092904642018 @default.
• W2509290464 countsByYear W25092904642019 @default.
• W2509290464 countsByYear W25092904642020 @default.
• W2509290464 countsByYear W25092904642021 @default.
• W2509290464 countsByYear W25092904642022 @default.
• W2509290464 crossrefType "journal-article" @default.
• W2509290464 hasAuthorship W2509290464A5026337679 @default.
• W2509290464 hasAuthorship W2509290464A5031947542 @default.
• W2509290464 hasAuthorship W2509290464A5047272214 @default.
• W2509290464 hasAuthorship W2509290464A5068589340 @default.
• W2509290464 hasAuthorship W2509290464A5069175003 @default.

• next