FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2509298311> ?p ?o ?g. }

• W2509298311 endingPage "2854" @default.
• W2509298311 startingPage "2838" @default.
• W2509298311 abstract "Previous studies showed that high levels of placenta growth factor (PlGF) correlated with increased plasma levels of endothelin-1 (ET-1), a potent vasoconstrictor, in sickle cell disease (SCD). PlGF-mediated transcription of the ET-1 gene occurs by activation of hypoxia inducible factor 1α (HIF-1α) and posttranscriptionally by microRNA 199a2 (miR-199a2), which targets the 3' untranslated region (UTR) of HIF-1α mRNA. However, relatively less is known about how PlGF represses the expression of miR-199a2 located in the DNM3 opposite strand (DNM3os) transcription unit. Here, we show that PlGF induces the expression of activated transcription factor 3 (ATF3), which, in association with accessory proteins (c-Jun dimerization protein 2 [JDP2], ATF2, and histone deacetylase 6 [HDAC6]), as determined by proteomic analysis, binds to the DNM3os promoter. Furthermore, we show that association of HDAC6 with ATF3 at its binding site in this promoter was correlated with repression of miR-199a2 transcription, as shown by DNM3os transcription reporter and chromatin immunoprecipitation (ChIP) assays. Tubacin, an inhibitor of HDAC6, antagonized PlGF-mediated repression of DNM3os/pre-miR-199a2 transcription with a concomitant reduction in ET-1 levels in cultured endothelial cells. Analysis of lung tissues from Berkeley sickle (BK-SS) mice showed increased levels of ATF3 and increased expression of ET-1. Delivery of tubacin to BK-SS mice significantly attenuated plasma ET-1 and PlGF levels. Our studies demonstrated that ATF3 in conjunction with HDAC6 acts as a transcriptional repressor of the DNM3os/miR-199a2 locus." @default.
• W2509298311 created "2016-09-16" @default.
• W2509298311 creator A5032447166 @default.
• W2509298311 creator A5040157246 @default.
• W2509298311 creator A5040427012 @default.
• W2509298311 creator A5067782844 @default.
• W2509298311 creator A5067822812 @default.
• W2509298311 creator A5087991513 @default.
• W2509298311 date "2016-11-01" @default.
• W2509298311 modified "2023-10-16" @default.
• W2509298311 title "Activated Transcription Factor 3 in Association with Histone Deacetylase 6 Negatively Regulates MicroRNA 199a2 Transcription by Chromatin Remodeling and Reduces Endothelin-1 Expression" @default.
• W2509298311 cites W1520623323 @default.
• W2509298311 cites W1583270829 @default.
• W2509298311 cites W1597678601 @default.
• W2509298311 cites W1875554126 @default.
• W2509298311 cites W1911505241 @default.
• W2509298311 cites W1964318436 @default.
• W2509298311 cites W1966590237 @default.
• W2509298311 cites W1975055822 @default.
• W2509298311 cites W1977708103 @default.
• W2509298311 cites W1977801036 @default.
• W2509298311 cites W1980814594 @default.
• W2509298311 cites W1996182612 @default.
• W2509298311 cites W2008079978 @default.
• W2509298311 cites W2009106854 @default.
• W2509298311 cites W2009826707 @default.
• W2509298311 cites W2009936217 @default.
• W2509298311 cites W2014928050 @default.
• W2509298311 cites W2019583759 @default.
• W2509298311 cites W2019792538 @default.
• W2509298311 cites W2021850499 @default.
• W2509298311 cites W2032360925 @default.
• W2509298311 cites W2032782468 @default.
• W2509298311 cites W203470123 @default.
• W2509298311 cites W2040024980 @default.
• W2509298311 cites W2040323431 @default.
• W2509298311 cites W2044225601 @default.
• W2509298311 cites W2050291403 @default.
• W2509298311 cites W2051114755 @default.
• W2509298311 cites W2051268134 @default.
• W2509298311 cites W2063292874 @default.
• W2509298311 cites W2063338364 @default.
• W2509298311 cites W2065543957 @default.
• W2509298311 cites W2096136598 @default.
• W2509298311 cites W2097881605 @default.
• W2509298311 cites W2098023991 @default.
• W2509298311 cites W2101127235 @default.
• W2509298311 cites W2102489631 @default.
• W2509298311 cites W2103573275 @default.
• W2509298311 cites W2107572492 @default.
• W2509298311 cites W2110315980 @default.
• W2509298311 cites W2115593774 @default.
• W2509298311 cites W2122537353 @default.
• W2509298311 cites W2138057170 @default.
• W2509298311 cites W2138891173 @default.
• W2509298311 cites W2143658931 @default.
• W2509298311 cites W2145221987 @default.
• W2509298311 cites W2147328009 @default.
• W2509298311 cites W2156363416 @default.
• W2509298311 cites W2158013083 @default.
• W2509298311 cites W2163252729 @default.
• W2509298311 cites W2171354819 @default.
• W2509298311 cites W2330978498 @default.
• W2509298311 cites W2739174192 @default.
• W2509298311 doi "https://doi.org/10.1128/mcb.00345-16" @default.
• W2509298311 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5086524" @default.
• W2509298311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27573019" @default.
• W2509298311 hasPublicationYear "2016" @default.
• W2509298311 type Work @default.
• W2509298311 sameAs 2509298311 @default.
• W2509298311 citedByCount "11" @default.
• W2509298311 countsByYear W25092983112017 @default.
• W2509298311 countsByYear W25092983112018 @default.
• W2509298311 countsByYear W25092983112019 @default.
• W2509298311 countsByYear W25092983112020 @default.
• W2509298311 countsByYear W25092983112021 @default.
• W2509298311 crossrefType "journal-article" @default.
• W2509298311 hasAuthorship W2509298311A5032447166 @default.
• W2509298311 hasAuthorship W2509298311A5040157246 @default.
• W2509298311 hasAuthorship W2509298311A5040427012 @default.
• W2509298311 hasAuthorship W2509298311A5067782844 @default.
• W2509298311 hasAuthorship W2509298311A5067822812 @default.
• W2509298311 hasAuthorship W2509298311A5087991513 @default.
• W2509298311 hasBestOaLocation W25092983111 @default.
• W2509298311 hasConcept C101762097 @default.
• W2509298311 hasConcept C104317684 @default.
• W2509298311 hasConcept C111936080 @default.
• W2509298311 hasConcept C132376346 @default.
• W2509298311 hasConcept C134320426 @default.
• W2509298311 hasConcept C150194340 @default.
• W2509298311 hasConcept C153911025 @default.
• W2509298311 hasConcept C191163429 @default.
• W2509298311 hasConcept C20291555 @default.
• W2509298311 hasConcept C2778305200 @default.
• W2509298311 hasConcept C54355233 @default.
• W2509298311 hasConcept C57467964 @default.
• W2509298311 hasConcept C64927066 @default.
• W2509298311 hasConcept C77179829 @default.

• next