FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2509313097> ?p ?o ?g. }

• W2509313097 abstract "Event Abstract Back to Event Evaluation of histomorphometric and neurochemical changes in the aluminium treated hippocampus following treatment with Huperzine A Nilesh K. Mitra1* 1 Taylor's University, Department of Anatomy, School of Medicine, Malaysia Aluminium (Al) is used in cooking utensils, as adjuvant in vaccines and is found in drinking water as a flocculent. The neurotoxic symptoms of aluminium exposure include speech disturbances, tremors, psychosis, partial memory loss and cognitive deficits, some of which mimic neurodegenerative diseases like Alzheimer’s and Parkinson’s Diseases. Huperzine A, a lycopodium alkaloid and acetylcholinesterase (AChE) inhibitor has been used as a neuroprotective agent in traditional Chinese medicine. The objective of this study was to determine the effect of Huperzine A on brain AChE and MAO activity and histomorphometry of hippocampal neurons in albino mice pre-treated with Aluminium Chloride. Female ICR mice (22 weeks, n=6) were treated intraperitoneally with Al (30mg/kg) for 14 days followed by post-treatment with saline, Huperzine A (0.5mg/kg), Huperzine A (0.2mg/kg) and Huperzine A (0.1mg/kg)(Al-Hup 0.1) for further 14 days. A control group was treated with saline. AChE and MAO levels were estimated using spectroflurometric methods from blood and brain samples. Thionin stained coronal serial sections (8 µ) of brain samples were used to estimate neuronal density of neurons of hippocampus using NIS Elements Software. Al treated mice showed decrease in serum AChE and increase in brain AChE. Al-Hup 0.1 group showed significant decrease in brain AChE activity. Brain MAO activity was increased by Al treatment, whereas, Huperzine A post–treatment decreased MAO activity significantly. The neuronal density in CA1, CA2 and CA3 areas of hippocampus following Al treatment showed significant reduction (p<0.001). All Huperzine A post-treatment groups showed increase in neuronal density significantly (p<0.001) in the 3 areas compared to Al-saline group. It can be concluded that although Al has a biphasic effect on serum and brain AChE, it has a persistent toxic effect on neurons of hippocampal formation. Huperzine A has neuro-protective effect on Al induced neurotoxicity in hippocampus. Keywords: in vivo, metal, Huperzine A (HupA), Neuroprotection, Hippocampus, Neurotoxin Conference: 14th Meeting of the Asian-Pacific Society for Neurochemistry, Kuala Lumpur, Malaysia, 27 Aug - 30 Aug, 2016. Presentation Type: Poster Presentation Session Topic: 14th Meeting of the Asian-Pacific Society for Neurochemistry Citation: Mitra NK (2016). Evaluation of histomorphometric and neurochemical changes in the aluminium treated hippocampus following treatment with Huperzine A. Conference Abstract: 14th Meeting of the Asian-Pacific Society for Neurochemistry. doi: 10.3389/conf.fncel.2016.36.00110 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 04 Aug 2016; Published Online: 11 Aug 2016. * Correspondence: Prof. Nilesh K Mitra, Taylor's University, Department of Anatomy, School of Medicine, Subang Jaya, Selangor, Malaysia, NileshKumar.Mitra@taylors.edu.my Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Nilesh K Mitra Google Nilesh K Mitra Google Scholar Nilesh K Mitra PubMed Nilesh K Mitra Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
• W2509313097 created "2016-09-16" @default.
• W2509313097 creator A5060760985 @default.
• W2509313097 date "2016-01-01" @default.
• W2509313097 modified "2023-09-27" @default.
• W2509313097 title "Evaluation of histomorphometric and neurochemical changes in the aluminium treated hippocampus following treatment with Huperzine A" @default.
• W2509313097 doi "https://doi.org/10.3389/conf.fncel.2016.36.00110" @default.
• W2509313097 hasPublicationYear "2016" @default.
• W2509313097 type Work @default.
• W2509313097 sameAs 2509313097 @default.
• W2509313097 citedByCount "0" @default.
• W2509313097 crossrefType "journal-article" @default.
• W2509313097 hasAuthorship W2509313097A5060760985 @default.
• W2509313097 hasBestOaLocation W25093130971 @default.
• W2509313097 hasConcept C126322002 @default.
• W2509313097 hasConcept C134018914 @default.
• W2509313097 hasConcept C181199279 @default.
• W2509313097 hasConcept C185592680 @default.
• W2509313097 hasConcept C25498285 @default.
• W2509313097 hasConcept C25876315 @default.
• W2509313097 hasConcept C2776409846 @default.
• W2509313097 hasConcept C2777397205 @default.
• W2509313097 hasConcept C2778816929 @default.
• W2509313097 hasConcept C2779059548 @default.
• W2509313097 hasConcept C2779491297 @default.
• W2509313097 hasConcept C2781161787 @default.
• W2509313097 hasConcept C29730261 @default.
• W2509313097 hasConcept C42219234 @default.
• W2509313097 hasConcept C55493867 @default.
• W2509313097 hasConcept C71924100 @default.
• W2509313097 hasConcept C98274493 @default.
• W2509313097 hasConceptScore W2509313097C126322002 @default.
• W2509313097 hasConceptScore W2509313097C134018914 @default.
• W2509313097 hasConceptScore W2509313097C181199279 @default.
• W2509313097 hasConceptScore W2509313097C185592680 @default.
• W2509313097 hasConceptScore W2509313097C25498285 @default.
• W2509313097 hasConceptScore W2509313097C25876315 @default.
• W2509313097 hasConceptScore W2509313097C2776409846 @default.
• W2509313097 hasConceptScore W2509313097C2777397205 @default.
• W2509313097 hasConceptScore W2509313097C2778816929 @default.
• W2509313097 hasConceptScore W2509313097C2779059548 @default.
• W2509313097 hasConceptScore W2509313097C2779491297 @default.
• W2509313097 hasConceptScore W2509313097C2781161787 @default.
• W2509313097 hasConceptScore W2509313097C29730261 @default.
• W2509313097 hasConceptScore W2509313097C42219234 @default.
• W2509313097 hasConceptScore W2509313097C55493867 @default.
• W2509313097 hasConceptScore W2509313097C71924100 @default.
• W2509313097 hasConceptScore W2509313097C98274493 @default.
• W2509313097 hasLocation W25093130971 @default.
• W2509313097 hasOpenAccess W2509313097 @default.
• W2509313097 hasPrimaryLocation W25093130971 @default.
• W2509313097 hasRelatedWork W1989712097 @default.
• W2509313097 hasRelatedWork W2019049150 @default.
• W2509313097 hasRelatedWork W2082194413 @default.
• W2509313097 hasRelatedWork W2083655129 @default.
• W2509313097 hasRelatedWork W2118070764 @default.
• W2509313097 hasRelatedWork W2509313097 @default.
• W2509313097 hasRelatedWork W294103427 @default.
• W2509313097 hasRelatedWork W2950448583 @default.
• W2509313097 hasRelatedWork W3153987184 @default.
• W2509313097 hasRelatedWork W3205373987 @default.
• W2509313097 hasVolume "10" @default.
• W2509313097 isParatext "false" @default.
• W2509313097 isRetracted "false" @default.
• W2509313097 magId "2509313097" @default.
• W2509313097 workType "article" @default.