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• W2509486054 startingPage "5023" @default.
• W2509486054 abstract "PD-L1 is an immunoinhibitory molecule that suppresses the activation of T cells, leading to the progression of tumors. Overexpression of PD-L1 in cancers such as gastric cancer, hepatocellular carcinoma, renal cell carcinoma, esophageal cancer, pancreatic cancer, ovarian cancer, and bladder cancer is associated with poor clinical outcomes. In contrast, PD-L1 expression correlates with better clinical outcomes in breast cancer and merkel cell carcinoma. The prognostic value of PD-L1 expression in lung cancer, colorectal cancer, and melanoma is controversial. Blocking antibodies that target PD-1 and PD-L1 have achieved remarkable response rates in cancer patients who have PD-L1-overexpressing tumors. However, using PD-L1 as an exclusive predictive biomarker for cancer immunotherapy is questionable due to the low accuracy of PD-L1 immunohistochemistry staining. Factors that affect the accuracy of PD-L1 immunohistochemistry staining are as follows. First, antibodies used in different studies have different sensitivity. Second, in different studies, the cut-off value of PD-L1 staining positivity is different. Third, PD-L1 expression in tumors is not uniform, and sampling time and location may affect the results of PD-L1 staining. Therefore, better understanding of tumor microenvironment and use of other biomarkers such as gene marker and combined index are necessary to better identify patients who will benefit from PD-1/PD-L1 checkpoint blockade therapy." @default.
• W2509486054 created "2016-09-16" @default.
• W2509486054 creator A5006822602 @default.
• W2509486054 creator A5006945544 @default.
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• W2509486054 creator A5086069157 @default.
• W2509486054 date "2016-08-01" @default.
• W2509486054 modified "2023-10-14" @default.
• W2509486054 title "PD-L1 expression in human cancers and its association with clinical outcomes" @default.
• W2509486054 cites W10477029 @default.
• W2509486054 cites W115125409 @default.
• W2509486054 cites W150408279 @default.
• W2509486054 cites W1513769484 @default.
• W2509486054 cites W1538902372 @default.
• W2509486054 cites W1893566975 @default.
• W2509486054 cites W1940241680 @default.
• W2509486054 cites W1966648901 @default.
• W2509486054 cites W1969765578 @default.
• W2509486054 cites W1971208896 @default.
• W2509486054 cites W1972882573 @default.
• W2509486054 cites W1975731864 @default.
• W2509486054 cites W1975916903 @default.
• W2509486054 cites W1976269164 @default.
• W2509486054 cites W1977381583 @default.
• W2509486054 cites W1977927677 @default.
• W2509486054 cites W1978857579 @default.
• W2509486054 cites W1979140041 @default.
• W2509486054 cites W1983093014 @default.
• W2509486054 cites W1990779902 @default.
• W2509486054 cites W1991235944 @default.
• W2509486054 cites W1994238092 @default.
• W2509486054 cites W1996145004 @default.
• W2509486054 cites W1996374378 @default.
• W2509486054 cites W1997462426 @default.
• W2509486054 cites W1998466036 @default.
• W2509486054 cites W1999075493 @default.
• W2509486054 cites W2005401733 @default.
• W2509486054 cites W2007980875 @default.
• W2509486054 cites W2009392040 @default.
• W2509486054 cites W2010492098 @default.
• W2509486054 cites W2016983859 @default.
• W2509486054 cites W2029086221 @default.
• W2509486054 cites W2030820484 @default.
• W2509486054 cites W2031391029 @default.
• W2509486054 cites W2033672531 @default.
• W2509486054 cites W2035660473 @default.
• W2509486054 cites W2036489403 @default.
• W2509486054 cites W2039614598 @default.
• W2509486054 cites W2040793402 @default.
• W2509486054 cites W2044184535 @default.
• W2509486054 cites W2049078823 @default.
• W2509486054 cites W2050302729 @default.
• W2509486054 cites W2052727153 @default.
• W2509486054 cites W2053353274 @default.
• W2509486054 cites W2053366731 @default.
• W2509486054 cites W2057499380 @default.
• W2509486054 cites W2057893793 @default.
• W2509486054 cites W2062952095 @default.
• W2509486054 cites W2066671159 @default.
• W2509486054 cites W2068081619 @default.
• W2509486054 cites W2070414437 @default.
• W2509486054 cites W2073382063 @default.
• W2509486054 cites W2073571081 @default.
• W2509486054 cites W2076308913 @default.
• W2509486054 cites W2081070412 @default.
• W2509486054 cites W2086437355 @default.
• W2509486054 cites W2097855813 @default.
• W2509486054 cites W2099751212 @default.
• W2509486054 cites W2104347254 @default.
• W2509486054 cites W2105396178 @default.
• W2509486054 cites W2105567953 @default.
• W2509486054 cites W2107564997 @default.
• W2509486054 cites W2112121482 @default.
• W2509486054 cites W2112927491 @default.
• W2509486054 cites W2115961668 @default.
• W2509486054 cites W2118982164 @default.
• W2509486054 cites W2121770645 @default.
• W2509486054 cites W2122639773 @default.
• W2509486054 cites W2128540669 @default.
• W2509486054 cites W2130207101 @default.
• W2509486054 cites W2136313650 @default.
• W2509486054 cites W2142160537 @default.
• W2509486054 cites W2143163879 @default.
• W2509486054 cites W2147592245 @default.
• W2509486054 cites W2150575159 @default.
• W2509486054 cites W2152061559 @default.
• W2509486054 cites W2155464214 @default.
• W2509486054 cites W2156353875 @default.
• W2509486054 cites W2156383220 @default.
• W2509486054 cites W2158348986 @default.
• W2509486054 cites W2161558877 @default.
• W2509486054 cites W2161765043 @default.
• W2509486054 cites W2162667703 @default.
• W2509486054 cites W2165625761 @default.
• W2509486054 cites W2171081063 @default.
• W2509486054 cites W2171480930 @default.
• W2509486054 cites W2171651941 @default.
• W2509486054 cites W2560367415 @default.

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