FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2509522016> ?p ?o ?g. }

• W2509522016 endingPage "e292" @default.
• W2509522016 startingPage "e292" @default.
• W2509522016 abstract "ObjectiveWe aimed to investigate clinical implication of CFTR gene polymorphisms in idiopathic infertile Caucasian-European men.DesignCross-sectional study.Materials and MethodsComplete socio-demographic, clinical and hormonal data from 311 consecutive idiopathic infertile men were analysed. Patients with endocrine disorders, varicocele, and known genetic abnormalities were excluded from the study. The Charlson Comorbidity Index (CCI; categorized 0 vs 1 vs ≥2) was used to score health-significant comorbidities. Testicular volume was recorded using a Prader orchidometer. Serum hormones were always measured in the morning (8-10 am). Analysis of the CFTR gene was performed for every patient through direct gene sequencing from peripheral blood samples. Patients with F508, R117H, and W1282X mutations were excluded from the study. Semen parameters were assessed based on 2010 World Health Organization reference criteria. Descriptive statistics and logistic regression models tested the association between CFTR gene polymorphisms and clinical, seminal, hormonal characteristics in our population.ResultsOf all, 46 (14.8%) men were diagnosed with CFTR polymorphisms. Men with CFTR polymorphisms did not differ from the remaining idiopathic ones except from having lower sperm PT motility (19% vs. 24%; p=0.02). At multivariable logistic regression analysis, the presence of any CFTR gene polymorphism (OR: 1.34; p=0.02) was the only independent predictor of PT motility <32% after accounting for patient age, BMI, FSH, and inhibin B values.ConclusionsCurrent findings suggested an association between CFTR polymorphisms and lower sperm PT motility. Such alteration might contribute to explain a discreet share of idiopathic male infertility. ObjectiveWe aimed to investigate clinical implication of CFTR gene polymorphisms in idiopathic infertile Caucasian-European men. We aimed to investigate clinical implication of CFTR gene polymorphisms in idiopathic infertile Caucasian-European men. DesignCross-sectional study. Cross-sectional study. Materials and MethodsComplete socio-demographic, clinical and hormonal data from 311 consecutive idiopathic infertile men were analysed. Patients with endocrine disorders, varicocele, and known genetic abnormalities were excluded from the study. The Charlson Comorbidity Index (CCI; categorized 0 vs 1 vs ≥2) was used to score health-significant comorbidities. Testicular volume was recorded using a Prader orchidometer. Serum hormones were always measured in the morning (8-10 am). Analysis of the CFTR gene was performed for every patient through direct gene sequencing from peripheral blood samples. Patients with F508, R117H, and W1282X mutations were excluded from the study. Semen parameters were assessed based on 2010 World Health Organization reference criteria. Descriptive statistics and logistic regression models tested the association between CFTR gene polymorphisms and clinical, seminal, hormonal characteristics in our population. Complete socio-demographic, clinical and hormonal data from 311 consecutive idiopathic infertile men were analysed. Patients with endocrine disorders, varicocele, and known genetic abnormalities were excluded from the study. The Charlson Comorbidity Index (CCI; categorized 0 vs 1 vs ≥2) was used to score health-significant comorbidities. Testicular volume was recorded using a Prader orchidometer. Serum hormones were always measured in the morning (8-10 am). Analysis of the CFTR gene was performed for every patient through direct gene sequencing from peripheral blood samples. Patients with F508, R117H, and W1282X mutations were excluded from the study. Semen parameters were assessed based on 2010 World Health Organization reference criteria. Descriptive statistics and logistic regression models tested the association between CFTR gene polymorphisms and clinical, seminal, hormonal characteristics in our population. ResultsOf all, 46 (14.8%) men were diagnosed with CFTR polymorphisms. Men with CFTR polymorphisms did not differ from the remaining idiopathic ones except from having lower sperm PT motility (19% vs. 24%; p=0.02). At multivariable logistic regression analysis, the presence of any CFTR gene polymorphism (OR: 1.34; p=0.02) was the only independent predictor of PT motility <32% after accounting for patient age, BMI, FSH, and inhibin B values. Of all, 46 (14.8%) men were diagnosed with CFTR polymorphisms. Men with CFTR polymorphisms did not differ from the remaining idiopathic ones except from having lower sperm PT motility (19% vs. 24%; p=0.02). At multivariable logistic regression analysis, the presence of any CFTR gene polymorphism (OR: 1.34; p=0.02) was the only independent predictor of PT motility <32% after accounting for patient age, BMI, FSH, and inhibin B values. ConclusionsCurrent findings suggested an association between CFTR polymorphisms and lower sperm PT motility. Such alteration might contribute to explain a discreet share of idiopathic male infertility. Current findings suggested an association between CFTR polymorphisms and lower sperm PT motility. Such alteration might contribute to explain a discreet share of idiopathic male infertility." @default.
• W2509522016 created "2016-09-16" @default.
• W2509522016 creator A5019599701 @default.
• W2509522016 creator A5021227506 @default.
• W2509522016 creator A5039363062 @default.
• W2509522016 creator A5072937184 @default.
• W2509522016 creator A5076870899 @default.
• W2509522016 date "2016-09-01" @default.
• W2509522016 modified "2023-09-29" @default.
• W2509522016 title "CFTR gene polymorphism are associated with reduced sperm progressive motility in idiopathic infertile men" @default.
• W2509522016 doi "https://doi.org/10.1016/j.fertnstert.2016.07.829" @default.
• W2509522016 hasPublicationYear "2016" @default.
• W2509522016 type Work @default.
• W2509522016 sameAs 2509522016 @default.
• W2509522016 citedByCount "0" @default.
• W2509522016 crossrefType "journal-article" @default.
• W2509522016 hasAuthorship W2509522016A5019599701 @default.
• W2509522016 hasAuthorship W2509522016A5021227506 @default.
• W2509522016 hasAuthorship W2509522016A5039363062 @default.
• W2509522016 hasAuthorship W2509522016A5072937184 @default.
• W2509522016 hasAuthorship W2509522016A5076870899 @default.
• W2509522016 hasBestOaLocation W25095220161 @default.
• W2509522016 hasConcept C126322002 @default.
• W2509522016 hasConcept C134018914 @default.
• W2509522016 hasConcept C151956035 @default.
• W2509522016 hasConcept C16685009 @default.
• W2509522016 hasConcept C2777338322 @default.
• W2509522016 hasConcept C2777589648 @default.
• W2509522016 hasConcept C2777632594 @default.
• W2509522016 hasConcept C2777688143 @default.
• W2509522016 hasConcept C2779234561 @default.
• W2509522016 hasConcept C2781087480 @default.
• W2509522016 hasConcept C2908647359 @default.
• W2509522016 hasConcept C29456083 @default.
• W2509522016 hasConcept C54355233 @default.
• W2509522016 hasConcept C71924100 @default.
• W2509522016 hasConcept C86803240 @default.
• W2509522016 hasConcept C99454951 @default.
• W2509522016 hasConceptScore W2509522016C126322002 @default.
• W2509522016 hasConceptScore W2509522016C134018914 @default.
• W2509522016 hasConceptScore W2509522016C151956035 @default.
• W2509522016 hasConceptScore W2509522016C16685009 @default.
• W2509522016 hasConceptScore W2509522016C2777338322 @default.
• W2509522016 hasConceptScore W2509522016C2777589648 @default.
• W2509522016 hasConceptScore W2509522016C2777632594 @default.
• W2509522016 hasConceptScore W2509522016C2777688143 @default.
• W2509522016 hasConceptScore W2509522016C2779234561 @default.
• W2509522016 hasConceptScore W2509522016C2781087480 @default.
• W2509522016 hasConceptScore W2509522016C2908647359 @default.
• W2509522016 hasConceptScore W2509522016C29456083 @default.
• W2509522016 hasConceptScore W2509522016C54355233 @default.
• W2509522016 hasConceptScore W2509522016C71924100 @default.
• W2509522016 hasConceptScore W2509522016C86803240 @default.
• W2509522016 hasConceptScore W2509522016C99454951 @default.
• W2509522016 hasIssue "3" @default.
• W2509522016 hasLocation W25095220161 @default.
• W2509522016 hasOpenAccess W2509522016 @default.
• W2509522016 hasPrimaryLocation W25095220161 @default.
• W2509522016 hasRelatedWork W1984646459 @default.
• W2509522016 hasRelatedWork W2014345024 @default.
• W2509522016 hasRelatedWork W2051884628 @default.
• W2509522016 hasRelatedWork W2079606162 @default.
• W2509522016 hasRelatedWork W2086718560 @default.
• W2509522016 hasRelatedWork W2355242135 @default.
• W2509522016 hasRelatedWork W3025888088 @default.
• W2509522016 hasRelatedWork W3131956893 @default.
• W2509522016 hasRelatedWork W3214279461 @default.
• W2509522016 hasRelatedWork W4283261506 @default.
• W2509522016 hasVolume "106" @default.
• W2509522016 isParatext "false" @default.
• W2509522016 isRetracted "false" @default.
• W2509522016 magId "2509522016" @default.
• W2509522016 workType "article" @default.