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- W2509533826 abstract "ABSTRACTIntroduction: Free Living Amoebae (FLA) are unicellular protozoa common to most soil and aquatic environments. Only members of the genus Acanthamoeba and the species Naegleria fowleri, Balamuthia mandrillaris and Sappinia diploidea are known to infect humans and other animals, often with fatal consequences. Acanthamoeba species are the causative agents of a sight threating infection of the cornea known as Acanthamoeba keratitis (AK) that mainly affects immunocompetent contact lens wearers and has shown an increased incidence in the recent years worldwide. To date, most of the available treatments and contact lens maintenance solutions are not fully effective against these pathogens.Areas covered: There is a clear need for novel fully effective therapeutic agents against AK. In the recent years the application of ‘phylopharmacology’ and RNAi has shown to be a reliable tool for the elucidation of novel drug targets and therapeutic agents. Current therapeutic options for AK as well as ongoing researc..." @default.
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- W2509533826 date "2016-09-02" @default.
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- W2509533826 title "Therapeutic targets and investigated treatment strategies inAcanthamoebakeratitis" @default.
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- W2509533826 doi "https://doi.org/10.1080/21678707.2016.1230060" @default.
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