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- W2509664575 abstract "While the current epigenetic drug development is still largely restricted to target DNA methylome, emerging evidence indicates that histone methylome is indeed another major epigenetic determinant for gene expression and frequently deregulated in acute myeloid leukaemia (AML). The recent advances in dissecting the molecular regulation and targeting histone methylome in AML together with the success in developing lead compounds specific to key histone methylation-modifying enzymes have revealed new opportunities for effective leukaemia treatment. In this article, we will review the emerging functions of histone methyltransferases and histone demethylases in AML, especially MLL-rearranged leukaemia. We will also examine recent preclinical and clinical studies that show significant promises of targeting these histone methylation-modifying enzymes for AML treatment." @default.
- W2509664575 created "2016-09-16" @default.
- W2509664575 creator A5050440806 @default.
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- W2509664575 date "2016-09-05" @default.
- W2509664575 modified "2023-10-13" @default.
- W2509664575 title "Epigenetic therapies by targeting aberrant histone methylome in AML: molecular mechanisms, current preclinical and clinical development" @default.
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- W2509664575 doi "https://doi.org/10.1038/onc.2016.315" @default.
- W2509664575 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5378929" @default.
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