FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2509721407> ?p ?o ?g. }

• W2509721407 endingPage "i780" @default.
• W2509721407 startingPage "i772" @default.
• W2509721407 abstract "Abstract Motivation Understanding the temporal behaviour of biological regulatory networks requires the integration of molecular information into a formal model. However, the analysis of model dynamics faces a combinatorial explosion as the number of regulatory components and interactions increases. Results We use model-checking techniques to verify sophisticated dynamical properties resulting from the model regulatory structure in the absence of kinetic assumption. We demonstrate the power of this approach by analysing a logical model of the molecular network controlling mammalian cell cycle. This approach enables a systematic analysis of model properties, the delineation of model limitations, and the assessment of various refinements and extensions based on recent experimental observations. The resulting logical model accounts for the main irreversible transitions between cell cycle phases, the sequential activation of cyclins, and the inhibitory role of Skp2, and further emphasizes the multifunctional role for the cell cycle inhibitor Rb. Availability and Implementation The original and revised mammalian cell cycle models are available in the model repository associated with the public modelling software GINsim (http://ginsim.org/node/189). Contact thieffry@ens.fr Supplementary information Supplementary data are available at Bioinformatics online." @default.
• W2509721407 created "2016-09-16" @default.
• W2509721407 creator A5000983836 @default.
• W2509721407 creator A5021141408 @default.
• W2509721407 creator A5035962405 @default.
• W2509721407 creator A5081933836 @default.
• W2509721407 date "2016-08-29" @default.
• W2509721407 modified "2023-10-05" @default.
• W2509721407 title "Logical model specification aided by model-checking techniques: application to the mammalian cell cycle regulation" @default.
• W2509721407 cites W1270845237 @default.
• W2509721407 cites W1914412773 @default.
• W2509721407 cites W1966383348 @default.
• W2509721407 cites W1969154599 @default.
• W2509721407 cites W1969727436 @default.
• W2509721407 cites W1970096724 @default.
• W2509721407 cites W1977198605 @default.
• W2509721407 cites W1986759841 @default.
• W2509721407 cites W1986960362 @default.
• W2509721407 cites W1996931202 @default.
• W2509721407 cites W1998798121 @default.
• W2509721407 cites W1999330214 @default.
• W2509721407 cites W2004006412 @default.
• W2509721407 cites W2004497068 @default.
• W2509721407 cites W2009307226 @default.
• W2509721407 cites W2011075906 @default.
• W2509721407 cites W2019630846 @default.
• W2509721407 cites W2031369606 @default.
• W2509721407 cites W2035233115 @default.
• W2509721407 cites W2041289840 @default.
• W2509721407 cites W2041652145 @default.
• W2509721407 cites W2044583546 @default.
• W2509721407 cites W2046538693 @default.
• W2509721407 cites W2052540412 @default.
• W2509721407 cites W2053961182 @default.
• W2509721407 cites W2056040174 @default.
• W2509721407 cites W2056164539 @default.
• W2509721407 cites W2075269458 @default.
• W2509721407 cites W2080921790 @default.
• W2509721407 cites W2091841161 @default.
• W2509721407 cites W2097144068 @default.
• W2509721407 cites W2102628825 @default.
• W2509721407 cites W2112651905 @default.
• W2509721407 cites W2114342401 @default.
• W2509721407 cites W2119874496 @default.
• W2509721407 cites W2120709000 @default.
• W2509721407 cites W2131029596 @default.
• W2509721407 cites W2131463591 @default.
• W2509721407 cites W2132935366 @default.
• W2509721407 cites W2136977672 @default.
• W2509721407 cites W2137590391 @default.
• W2509721407 cites W2139391027 @default.
• W2509721407 cites W2142400903 @default.
• W2509721407 cites W2151962896 @default.
• W2509721407 cites W2152028923 @default.
• W2509721407 cites W2154281042 @default.
• W2509721407 cites W2157947216 @default.
• W2509721407 cites W2163931326 @default.
• W2509721407 cites W2297772255 @default.
• W2509721407 cites W2436013910 @default.
• W2509721407 cites W58125149 @default.
• W2509721407 doi "https://doi.org/10.1093/bioinformatics/btw457" @default.
• W2509721407 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27587700" @default.
• W2509721407 hasPublicationYear "2016" @default.
• W2509721407 type Work @default.
• W2509721407 sameAs 2509721407 @default.
• W2509721407 citedByCount "37" @default.
• W2509721407 countsByYear W25097214072016 @default.
• W2509721407 countsByYear W25097214072018 @default.
• W2509721407 countsByYear W25097214072019 @default.
• W2509721407 countsByYear W25097214072020 @default.
• W2509721407 countsByYear W25097214072021 @default.
• W2509721407 countsByYear W25097214072022 @default.
• W2509721407 countsByYear W25097214072023 @default.
• W2509721407 crossrefType "journal-article" @default.
• W2509721407 hasAuthorship W2509721407A5000983836 @default.
• W2509721407 hasAuthorship W2509721407A5021141408 @default.
• W2509721407 hasAuthorship W2509721407A5035962405 @default.
• W2509721407 hasAuthorship W2509721407A5081933836 @default.
• W2509721407 hasBestOaLocation W25097214071 @default.
• W2509721407 hasConcept C110251889 @default.
• W2509721407 hasConcept C115903868 @default.
• W2509721407 hasConcept C1491633281 @default.
• W2509721407 hasConcept C199360897 @default.
• W2509721407 hasConcept C203702819 @default.
• W2509721407 hasConcept C2777904410 @default.
• W2509721407 hasConcept C29537977 @default.
• W2509721407 hasConcept C41008148 @default.
• W2509721407 hasConcept C54355233 @default.
• W2509721407 hasConcept C67186912 @default.
• W2509721407 hasConcept C70721500 @default.
• W2509721407 hasConcept C80444323 @default.
• W2509721407 hasConcept C86803240 @default.
• W2509721407 hasConceptScore W2509721407C110251889 @default.
• W2509721407 hasConceptScore W2509721407C115903868 @default.
• W2509721407 hasConceptScore W2509721407C1491633281 @default.
• W2509721407 hasConceptScore W2509721407C199360897 @default.
• W2509721407 hasConceptScore W2509721407C203702819 @default.
• W2509721407 hasConceptScore W2509721407C2777904410 @default.

• next