Matches in SemOpenAlex for { <https://semopenalex.org/work/W2509849114> ?p ?o ?g. }
- W2509849114 abstract "Amyotrophic lateral sclerosis (ALS) is a fatal, rapidly progressive neurodegenerative disease that mainly affects the motor system. A number of potentially neuroprotective and neurorestorative disease-modifying drugs are currently in clinical development. At present, the evaluation of a drug’s clinical efficacy in ALS is based on the ALS Functional Rating Scale Revised, motor tests and survival. However, these endpoints are general, variable and late-stage measures of the ALS disease process and thus require the long-term assessment of large cohorts. Hence, there is a need for more sensitive radiological biomarkers. Various sequences for magnetic resonance imaging (MRI) of the brain and spinal cord have may have value as surrogate biomarkers for use in future clinical trials. Here, we review the MRI findings in ALS, their clinical correlations, and their limitations and potential role as biomarkers. The PubMed database was screened to identify studies using MRI in ALS. We included general MRI studies with a control group and an ALS group and longitudinal studies even if a control group was lacking. A total of 116 studies were analysed with MRI data and clinical correlations. The most disease-sensitive MRI patterns are in motor regions but the brain is more broadly affected. Despite the existing MRI biomarkers, there is a need for large cohorts with long term MRI and clinical follow-up. MRI assessment could be improved by standardized MRI protocols with multicentre studies." @default.
- W2509849114 created "2016-09-16" @default.
- W2509849114 creator A5011904813 @default.
- W2509849114 creator A5014732002 @default.
- W2509849114 creator A5034858486 @default.
- W2509849114 creator A5040728494 @default.
- W2509849114 creator A5056234955 @default.
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- W2509849114 creator A5068762264 @default.
- W2509849114 creator A5079362824 @default.
- W2509849114 creator A5089570742 @default.
- W2509849114 date "2016-08-27" @default.
- W2509849114 modified "2023-10-09" @default.
- W2509849114 title "The value of magnetic resonance imaging as a biomarker for amyotrophic lateral sclerosis: a systematic review" @default.
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