Matches in SemOpenAlex for { <https://semopenalex.org/work/W2509875655> ?p ?o ?g. }
- W2509875655 abstract "Abstract Heparanase (HPSE) is the only endo-β-D-glucuronidase that is correlated with the progression of neuroblastoma (NB), the most common extracranial malignancy in childhood. However, the mechanisms underlying HPSE expression in NB still remain largely unknown. Herein, through analyzing cis -regulatory elements and mining public microarray datasets, we identified SMAD family member 4 (Smad4) as a crucial transcription regulator of HPSE in NB. We demonstrated that Smad4 repressed the HPSE expression at the transcriptional levels in NB cells. Mechanistically, Smad4 suppressed the HPSE expression through directly binding to its promoter and repressing the lymphoid enhancer binding factor 1 (LEF1)-facilitated transcription of HPSE via physical interaction. Gain- and loss-of-function studies demonstrated that Smad4 inhibited the growth, invasion, metastasis, and angiogenesis of NB cells in vitro and in vivo . Restoration of HPSE expression prevented the NB cells from changes in these biological features induced by Smad4. In clinical NB specimens, Smad4 was under-expressed and inversely correlated with HPSE levels, while LEF1 was highly expressed and positively correlated with HPSE expression. Patients with high Smad4 expression, low LEF1 or HPSE levels had greater survival probability. These results demonstrate that Smad4 suppresses the tumorigenesis and aggressiveness of NB through repressing the HPSE expression." @default.
- W2509875655 created "2016-09-16" @default.
- W2509875655 creator A5034556779 @default.
- W2509875655 creator A5037798401 @default.
- W2509875655 creator A5038851564 @default.
- W2509875655 creator A5040024882 @default.
- W2509875655 creator A5052157386 @default.
- W2509875655 creator A5058060903 @default.
- W2509875655 creator A5061672936 @default.
- W2509875655 creator A5070527724 @default.
- W2509875655 creator A5074839030 @default.
- W2509875655 creator A5074894865 @default.
- W2509875655 creator A5087070308 @default.
- W2509875655 date "2016-09-06" @default.
- W2509875655 modified "2023-10-12" @default.
- W2509875655 title "Smad4 suppresses the tumorigenesis and aggressiveness of neuroblastoma through repressing the expression of heparanase" @default.
- W2509875655 cites W1526312778 @default.
- W2509875655 cites W1539038113 @default.
- W2509875655 cites W1575139878 @default.
- W2509875655 cites W1595424060 @default.
- W2509875655 cites W1667991218 @default.
- W2509875655 cites W1869301205 @default.
- W2509875655 cites W1973186568 @default.
- W2509875655 cites W1977001186 @default.
- W2509875655 cites W1978851875 @default.
- W2509875655 cites W1983542744 @default.
- W2509875655 cites W1985237160 @default.
- W2509875655 cites W1986936841 @default.
- W2509875655 cites W1993951400 @default.
- W2509875655 cites W1996269830 @default.
- W2509875655 cites W1999909894 @default.
- W2509875655 cites W2010117209 @default.
- W2509875655 cites W2012836529 @default.
- W2509875655 cites W2018631055 @default.
- W2509875655 cites W2022064394 @default.
- W2509875655 cites W2026151657 @default.
- W2509875655 cites W2037810072 @default.
- W2509875655 cites W2046931245 @default.
- W2509875655 cites W2048248981 @default.
- W2509875655 cites W2048489220 @default.
- W2509875655 cites W2051045103 @default.
- W2509875655 cites W2052096221 @default.
- W2509875655 cites W2062110955 @default.
- W2509875655 cites W2063628317 @default.
- W2509875655 cites W2065741271 @default.
- W2509875655 cites W2075497099 @default.
- W2509875655 cites W2076097930 @default.
- W2509875655 cites W2078518265 @default.
- W2509875655 cites W2097775173 @default.
- W2509875655 cites W2100522747 @default.
- W2509875655 cites W2103031848 @default.
- W2509875655 cites W2106452303 @default.
- W2509875655 cites W2114264336 @default.
- W2509875655 cites W2117040837 @default.
- W2509875655 cites W2122523193 @default.
- W2509875655 cites W2123018511 @default.
- W2509875655 cites W2124280040 @default.
- W2509875655 cites W2126140637 @default.
- W2509875655 cites W2129560190 @default.
- W2509875655 cites W2133598334 @default.
- W2509875655 cites W2136270229 @default.
- W2509875655 cites W2143147807 @default.
- W2509875655 cites W2146029811 @default.
- W2509875655 cites W2147415210 @default.
- W2509875655 cites W2147769151 @default.
- W2509875655 cites W2148123056 @default.
- W2509875655 cites W2153550523 @default.
- W2509875655 cites W2156764890 @default.
- W2509875655 cites W2165575535 @default.
- W2509875655 cites W2166541157 @default.
- W2509875655 cites W2169195119 @default.
- W2509875655 cites W2326280462 @default.
- W2509875655 cites W2409030188 @default.
- W2509875655 cites W4235438234 @default.
- W2509875655 cites W640275200 @default.
- W2509875655 doi "https://doi.org/10.1038/srep32628" @default.
- W2509875655 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5011643" @default.
- W2509875655 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27595937" @default.
- W2509875655 hasPublicationYear "2016" @default.
- W2509875655 type Work @default.
- W2509875655 sameAs 2509875655 @default.
- W2509875655 citedByCount "15" @default.
- W2509875655 countsByYear W25098756552017 @default.
- W2509875655 countsByYear W25098756552018 @default.
- W2509875655 countsByYear W25098756552020 @default.
- W2509875655 countsByYear W25098756552021 @default.
- W2509875655 countsByYear W25098756552022 @default.
- W2509875655 crossrefType "journal-article" @default.
- W2509875655 hasAuthorship W2509875655A5034556779 @default.
- W2509875655 hasAuthorship W2509875655A5037798401 @default.
- W2509875655 hasAuthorship W2509875655A5038851564 @default.
- W2509875655 hasAuthorship W2509875655A5040024882 @default.
- W2509875655 hasAuthorship W2509875655A5052157386 @default.
- W2509875655 hasAuthorship W2509875655A5058060903 @default.
- W2509875655 hasAuthorship W2509875655A5061672936 @default.
- W2509875655 hasAuthorship W2509875655A5070527724 @default.
- W2509875655 hasAuthorship W2509875655A5074839030 @default.
- W2509875655 hasAuthorship W2509875655A5074894865 @default.
- W2509875655 hasAuthorship W2509875655A5087070308 @default.
- W2509875655 hasBestOaLocation W25098756551 @default.