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• W2509888008 abstract "Solid lipid-polymer hybrid nanocarrier (LPN) was previously reported to achieve high siRNA transfection efficiency and induce sustained RNAi-based chemosensitizing effect at cellular level. In this study, our objectives were to evaluate the in vivo biodistribution of LPNs in a prostate cancer model and determine the factors that potentially affect tumor penetration by LPNs. The LPN formulation with the highest transfection efficiency (64%) and stability was selected for the study. Mice bearing tumors of PC-3Mcells were treated with LPNs labeled with IR780 or AF647-siRNA. Near infrared imaging showed that LPNs achieved favorable in vivo biodistribution with high tumor/low organ ratios. LPN accumulation was also observed in liver metastatic tissue. Result of extravasation study confirmed that encapsulated siRNA molecules were able to escape into the tumor tissue at the extravascular area. When LPN levels in large (volume>750mm3) and small (<500mm3) tumors were compared, no significant difference was observed. However, both docetaxel pretreatment (72hbefore LPN) and concurrent docetaxel treatment significantly enhanced the tumor LPN levels by 3.9- and 3.1-fold, respectively (both p<0.01). In conclusion, LPN is a promising carrier system to deliver RNAi therapy to solid malignancies that also receive chemotherapy." @default.
• W2509888008 created "2016-09-16" @default.
• W2509888008 creator A5055417590 @default.
• W2509888008 creator A5056540270 @default.
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• W2509888008 date "2016-11-01" @default.
• W2509888008 modified "2023-09-23" @default.
• W2509888008 title "A biodistribution study of solid lipid-polyethyleneimine hybrid nanocarrier for cancer RNAi therapy" @default.
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• W2509888008 doi "https://doi.org/10.1016/j.ejpb.2016.08.014" @default.
• W2509888008 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5464759" @default.
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