Matches in SemOpenAlex for { <https://semopenalex.org/work/W2509888465> ?p ?o ?g. }
- W2509888465 abstract "Nucleic acids are prone to structural polymorphism and a number of structures may be formed in addition to the well-known DNA double helix. Among these is a family of nucleic acid four-stranded structures known as G-quadruplexes (G4). These quadruplex structures can be formed by sequences containing repetitive guanine-rich tracks and the analysis of Non-B-DNA database indicated an enrichment of these sequences in genomic regions controlling cellular proliferation, such as for example in the promoter regions of c- MYC, k-RAS, c-KIT, HSP90 and VEGF among others. The broad concept of G4 targeting with small molecules is now generally accepted as a promising novel approach to anticancer therapy and several small molecules with antiproliferative activity in cancer cell lines have also been shown to stabilize these DNA structures, thus suggesting a potential application of G4-interactive small molecules as new anticancer drugs. Herein we review, by targeted oncogene and main chemical scaffold, those G4-interactive small molecules with reported gene expression modulatory activity in cancer cell lines. The data obtained so far are encouraging but further efforts are needed to validate G4 as drug targets and optimize the structure of G4- interactive small molecules into new anticancer drugs. Keywords: Anticancer, oncogenes, transcriptional regulation, quadruplexes, DNA, indoloquinolines, porphyrins, drug target." @default.
- W2509888465 created "2016-09-16" @default.
- W2509888465 creator A5052629340 @default.
- W2509888465 creator A5054088299 @default.
- W2509888465 date "2018-01-11" @default.
- W2509888465 modified "2023-09-23" @default.
- W2509888465 title "Oncogene Expression Modulation in Cancer Cell Lines by DNA G-Quadruplex-Interactive Small Molecules" @default.
- W2509888465 cites W1008864505 @default.
- W2509888465 cites W1146966998 @default.
- W2509888465 cites W1450574606 @default.
- W2509888465 cites W1523506289 @default.
- W2509888465 cites W1568678893 @default.
- W2509888465 cites W1571487648 @default.
- W2509888465 cites W1598901139 @default.
- W2509888465 cites W1752312133 @default.
- W2509888465 cites W1788301610 @default.
- W2509888465 cites W1820187337 @default.
- W2509888465 cites W1851042374 @default.
- W2509888465 cites W1887262817 @default.
- W2509888465 cites W1921143360 @default.
- W2509888465 cites W1943467063 @default.
- W2509888465 cites W1965013034 @default.
- W2509888465 cites W1966035396 @default.
- W2509888465 cites W1967798131 @default.
- W2509888465 cites W1969583921 @default.
- W2509888465 cites W1972311492 @default.
- W2509888465 cites W1974665005 @default.
- W2509888465 cites W1975890865 @default.
- W2509888465 cites W1975972551 @default.
- W2509888465 cites W1976523417 @default.
- W2509888465 cites W1976548990 @default.
- W2509888465 cites W1978670494 @default.
- W2509888465 cites W1979521450 @default.
- W2509888465 cites W1980822832 @default.
- W2509888465 cites W1983338915 @default.
- W2509888465 cites W1983506450 @default.
- W2509888465 cites W1985360090 @default.
- W2509888465 cites W1988316350 @default.
- W2509888465 cites W1989226481 @default.
- W2509888465 cites W1990393306 @default.
- W2509888465 cites W1990635146 @default.
- W2509888465 cites W1991590162 @default.
- W2509888465 cites W1991797965 @default.
- W2509888465 cites W1996112634 @default.
- W2509888465 cites W1996463890 @default.
- W2509888465 cites W1996975096 @default.
- W2509888465 cites W1997923564 @default.
- W2509888465 cites W1998664010 @default.
- W2509888465 cites W1999609185 @default.
- W2509888465 cites W2000292756 @default.
- W2509888465 cites W2005146652 @default.
- W2509888465 cites W2006578412 @default.
- W2509888465 cites W2007634776 @default.
- W2509888465 cites W2007965495 @default.
- W2509888465 cites W2010106126 @default.
- W2509888465 cites W2011215127 @default.
- W2509888465 cites W2011886148 @default.
- W2509888465 cites W2011924190 @default.
- W2509888465 cites W2012353207 @default.
- W2509888465 cites W2014917043 @default.
- W2509888465 cites W2016003976 @default.
- W2509888465 cites W2016968345 @default.
- W2509888465 cites W2018937138 @default.
- W2509888465 cites W2020038227 @default.
- W2509888465 cites W2021191052 @default.
- W2509888465 cites W2021817265 @default.
- W2509888465 cites W2022287291 @default.
- W2509888465 cites W2024582476 @default.
- W2509888465 cites W2024811932 @default.
- W2509888465 cites W2025541400 @default.
- W2509888465 cites W2026290591 @default.
- W2509888465 cites W2026996188 @default.
- W2509888465 cites W2028923735 @default.
- W2509888465 cites W2028942646 @default.
- W2509888465 cites W2030493864 @default.
- W2509888465 cites W2031467156 @default.
- W2509888465 cites W2032972450 @default.
- W2509888465 cites W2033106731 @default.
- W2509888465 cites W2034218185 @default.
- W2509888465 cites W2035030010 @default.
- W2509888465 cites W2035156990 @default.
- W2509888465 cites W2037411295 @default.
- W2509888465 cites W2037827118 @default.
- W2509888465 cites W2038502978 @default.
- W2509888465 cites W2041626076 @default.
- W2509888465 cites W2041682746 @default.
- W2509888465 cites W2042399343 @default.
- W2509888465 cites W2043588576 @default.
- W2509888465 cites W2043720815 @default.
- W2509888465 cites W2044279725 @default.
- W2509888465 cites W2044333356 @default.
- W2509888465 cites W2044480512 @default.
- W2509888465 cites W2045782790 @default.
- W2509888465 cites W2048286707 @default.
- W2509888465 cites W2050913592 @default.
- W2509888465 cites W2051300646 @default.
- W2509888465 cites W2052024409 @default.
- W2509888465 cites W2054177711 @default.
- W2509888465 cites W2054243678 @default.
- W2509888465 cites W2054452888 @default.