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- W2509919702 abstract "During cellular uptake, diphtheria toxin delivers its catalytic domain DTA from acidified endosomes into the cytosol, which requires reduction of the disulfide linking DTA to the transport domain. In vitro, thioredoxin reduces this disulfide and thioredoxin reductase (TrxR) is part of a cytosolic complex facilitating DTA-translocation. We found that the TrxR-specific inhibitor auranofin prevented DTA delivery into the cytosol and intoxication of HeLa cells with diphtheria toxin, offering perspectives for novel pharmacological strategies against diphtheria." @default.
- W2509919702 created "2016-09-16" @default.
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- W2509919702 date "2016-09-01" @default.
- W2509919702 modified "2023-09-25" @default.
- W2509919702 title "Improving chemical risk assessment through tiered and targeted application of exposure assessment" @default.
- W2509919702 doi "https://doi.org/10.1016/j.toxlet.2016.06.1246" @default.
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