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- W2510058837 abstract "Significance Natural killer (NK) cells are well known to serve as effecter cells in Th1-type immune responses, whereas their roles in Th2-type immune responses are largely unknown. In this study, we describe a previously unidentified pathway wherein IL-4, an initiator cytokine of Th2-type immune responses, induces development of highly activated murine NK cells in vivo. We show that IL-4 overexpression remarkably increases tissue-resident macrophages, which contributes to NK-cell proliferation via production of IL-15. The NK cells induced by IL-4 secrete a large amount of IFN-γ in response to IL-12, an initiator cytokine of Th1-type immune responses, and also exhibit high cytotoxicity against tumor cells. These results reveal the novel role of IL-4 in immune responses through the induction of unique NK cells." @default.
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- W2510058837 date "2016-08-22" @default.
- W2510058837 modified "2023-10-17" @default.
- W2510058837 title "NK cells activated by Interleukin-4 in cooperation with Interleukin-15 exhibit distinctive characteristics" @default.
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- W2510058837 doi "https://doi.org/10.1073/pnas.1600112113" @default.
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