FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W251007907> ?p ?o ?g. }

• W251007907 abstract "Association studies suggest that thyroid hormone receptor β (TRβ) could function as a tumor suppressor in breast cancer development, but unequivocal evidence is still lacking. To understand the role of TRβ in breast tumor development, we adopted the gain-of-function approach by stably expressing the THRB gene in a human breast cancer cell line, MCF-7 (MCF-7-TRβ). Parental MCF-7 cells express the estrogen receptor, but not TRs. MCF-7 cells, stably expressing only the selectable marker, the Neo gene, were also generated as control for comparison (MCF-7-Neo cells). Cell-based studies indicate that the estrogen (E2)-dependent growth of MCF-7 cells was inhibited by the expression of TRβ in the presence of the thyroid hormone (T3). In a xenograft mouse model, large tumors rapidly developed after inoculation of MCF-7-Neo cells in athymic mice. In contrast, markedly smaller tumors (98% smaller) were found when MCF-7-TRβ cells were inoculated in athymic mice, indicating that TRβ inhibited the E2-dependent tumor growth of MCF-7 cells. Further detailed molecular analysis showed that TRβ acted to activate apoptosis and decrease proliferation of tumor cells, resulting in inhibition of tumor growth. The TRβ-mediated inhibition of tumor growth was elucidated via down-regulation of the JAK-STAT-cyclin D pathways. This in vivo evidence shows that TRβ could act as a tumor suppressor in breast tumorigenesis. The present study provides new insights into the role of TR in breast cancer." @default.
• W251007907 created "2016-06-24" @default.
• W251007907 creator A5029282378 @default.
• W251007907 creator A5050397865 @default.
• W251007907 creator A5084518776 @default.
• W251007907 date "2013-01-01" @default.
• W251007907 modified "2023-09-24" @default.
• W251007907 title "Inhibition of estrogen-dependent tumorigenesis by the thyroid hormone receptor β in xenograft models." @default.
• W251007907 cites W146822916 @default.
• W251007907 cites W1539489658 @default.
• W251007907 cites W1550156431 @default.
• W251007907 cites W1573928282 @default.
• W251007907 cites W1858612037 @default.
• W251007907 cites W1872414351 @default.
• W251007907 cites W1974224857 @default.
• W251007907 cites W1996031072 @default.
• W251007907 cites W1998347125 @default.
• W251007907 cites W2003663220 @default.
• W251007907 cites W2005041145 @default.
• W251007907 cites W2010503486 @default.
• W251007907 cites W2012979834 @default.
• W251007907 cites W2020062532 @default.
• W251007907 cites W2021171182 @default.
• W251007907 cites W2021932599 @default.
• W251007907 cites W2032471037 @default.
• W251007907 cites W2040712355 @default.
• W251007907 cites W2042343487 @default.
• W251007907 cites W2042794591 @default.
• W251007907 cites W2043685412 @default.
• W251007907 cites W2048685600 @default.
• W251007907 cites W2049281953 @default.
• W251007907 cites W2054543347 @default.
• W251007907 cites W2064122825 @default.
• W251007907 cites W2064469818 @default.
• W251007907 cites W2066501495 @default.
• W251007907 cites W2081145901 @default.
• W251007907 cites W2088279869 @default.
• W251007907 cites W2099350273 @default.
• W251007907 cites W2103885797 @default.
• W251007907 cites W2105048300 @default.
• W251007907 cites W2107795884 @default.
• W251007907 cites W2108432765 @default.
• W251007907 cites W2115305839 @default.
• W251007907 cites W2117010948 @default.
• W251007907 cites W2118943568 @default.
• W251007907 cites W2119119522 @default.
• W251007907 cites W2120779205 @default.
• W251007907 cites W2127048711 @default.
• W251007907 cites W2136303773 @default.
• W251007907 cites W2138388945 @default.
• W251007907 cites W2138612858 @default.
• W251007907 cites W2152212770 @default.
• W251007907 cites W2154608244 @default.
• W251007907 cites W2160166542 @default.
• W251007907 cites W2463600435 @default.
• W251007907 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3696536" @default.
• W251007907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23841029" @default.
• W251007907 hasPublicationYear "2013" @default.
• W251007907 type Work @default.
• W251007907 sameAs 251007907 @default.
• W251007907 citedByCount "14" @default.
• W251007907 countsByYear W2510079072014 @default.
• W251007907 countsByYear W2510079072015 @default.
• W251007907 countsByYear W2510079072016 @default.
• W251007907 countsByYear W2510079072018 @default.
• W251007907 countsByYear W2510079072019 @default.
• W251007907 countsByYear W2510079072021 @default.
• W251007907 countsByYear W2510079072022 @default.
• W251007907 crossrefType "journal-article" @default.
• W251007907 hasAuthorship W251007907A5029282378 @default.
• W251007907 hasAuthorship W251007907A5050397865 @default.
• W251007907 hasAuthorship W251007907A5084518776 @default.
• W251007907 hasConcept C109115496 @default.
• W251007907 hasConcept C121608353 @default.
• W251007907 hasConcept C126322002 @default.
• W251007907 hasConcept C134018914 @default.
• W251007907 hasConcept C149574134 @default.
• W251007907 hasConcept C23589133 @default.
• W251007907 hasConcept C2777164284 @default.
• W251007907 hasConcept C2779761222 @default.
• W251007907 hasConcept C502942594 @default.
• W251007907 hasConcept C526584372 @default.
• W251007907 hasConcept C530470458 @default.
• W251007907 hasConcept C54355233 @default.
• W251007907 hasConcept C555283112 @default.
• W251007907 hasConcept C62112901 @default.
• W251007907 hasConcept C71924100 @default.
• W251007907 hasConcept C84606932 @default.
• W251007907 hasConcept C86803240 @default.
• W251007907 hasConceptScore W251007907C109115496 @default.
• W251007907 hasConceptScore W251007907C121608353 @default.
• W251007907 hasConceptScore W251007907C126322002 @default.
• W251007907 hasConceptScore W251007907C134018914 @default.
• W251007907 hasConceptScore W251007907C149574134 @default.
• W251007907 hasConceptScore W251007907C23589133 @default.
• W251007907 hasConceptScore W251007907C2777164284 @default.
• W251007907 hasConceptScore W251007907C2779761222 @default.
• W251007907 hasConceptScore W251007907C502942594 @default.
• W251007907 hasConceptScore W251007907C526584372 @default.
• W251007907 hasConceptScore W251007907C530470458 @default.

• next