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- W2510103481 abstract "We hypothesized that the viscoelastic properties of the respiratory system should have significant implications for the energetically optimal frequency of breathing, in view of the fact that these properties cause marked dependencies of over- all system resistance and elastance on frequency. To test our hypothesis we simulated two models of canine and human res- piratory system mechanics durin.g sinusoidal breathing and cal- culated the inspiratory work (W1) and pressure-time integral (PTI) per minute under both resting and exercise conditions. The two models werea two-compartment viscoelastic model and a single-compartment model. Requiring minute alveolar venti- lation to be fixed, we found that both models predicted almost identical optimum breathing frequencies. The calculated PTI was very insensitive to increases in breathing frequency above the optimal frequencies, while 14/z was found to increase slowly with frequency above its optimum. In contrast, both ~ and PTI increased sharply as frequency decreased below their re- spective optima. A sensitivity analysis showed that the model predictions were very insensitive to the elastance and resistance values chosen to characterize tissue viscoelasticity. We conclude that the 14el criterion for choosing the frequency of breathing is compatible with observations in nature, whereas the optimal frequency predictions of the PTI are rather too high. Both cri- teria allow for a fairly wide margin of choice in frequency above the optimum values without incurring excessive additional en- ergy expenditure. Furthermore, contrary to our expectations, the viscoelastic properties of the respiratory system tissues do not pose a noticeable problem to the respiratory controller in terms of energy expenditure. Keywords-Work of breathing, Inspiratory pressure-time in- tegral, Respiratory modeling, Dogs, Humans." @default.
- W2510103481 created "2016-09-16" @default.
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- W2510103481 date "1993-01-01" @default.
- W2510103481 modified "2023-09-27" @default.
- W2510103481 title "Influence of the Viscoelastic Properties of the Respiratory System on the Energetically Optimum Breathing Frequency" @default.
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