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- W2510106902 abstract "Background: Homocysteine action in the ischemic stroke (IS) development remains unclear, especially in young adults, where the role of metabolic disorders is more significant. Aims: The study aims to determine the effect of hyperhomocysteinemia on the stroke severity and the risk of disabling neurological deficit in non-cardiembolic stroke in young adults. Design: This is a blinded, randomized study, which enrolled 50 young patients (18-45 years) with non-cardioembolic IS and the control group of 40 patients (46 years and older) with non-cardioembolic IS. Neurological deficit was assessed using NIHSS and mRs scales. Monitoring median was 3 years, evaluation interval was 3 month. Outcomes: Recurrent stroke, TIA, myocardial infarction, persistent disabling deficit (mRs score ≥3 unchanged during 6 month). Results: Regression analysis of data obtained from 50 patients showed that homocysteine level independently affects NIHSS score (R2 = 0.75, p < 0.05) in stroke acute phase, but only in young adults. ROC-curve and logit-regression analysis showed that in young patients homocysteine level over 13.22 mmol/l in the stroke acute phase is a predictor of mRs score ≥3 in 3 month after stroke (OR = 1.9, 95% CI 1.2-6.1, sensitivity 95.8%, specificity 71.4%, p < 0.05). Conclusion: Homocysteine affects the non-cardioembolic IS severity and predicts the disabling deficit in stroke sub-acute phase, but only in young adults. The aim of the future researches should be to determine the effectiveness of B-vitamin supplementation in secondary stroke prevention in young adults." @default.
- W2510106902 created "2016-09-16" @default.
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- W2510106902 date "2015-10-01" @default.
- W2510106902 modified "2023-09-25" @default.
- W2510106902 title "Hyperhomocysteinemia affects the stroke severity and the risk of disabling deficit in non-cardioembolic stroke in young adults" @default.
- W2510106902 doi "https://doi.org/10.1016/j.jns.2015.08.1338" @default.
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