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• W2510108608 abstract "This study presents the first investigation of the antiviral effects of the liposome-encapsulated PolyICLC (LE-PolyICLC) on Dengue virus (DENV) in a mouse model. In vivo efficacy studies showed that LE-PolyICLC acted to increase antiviral mechanisms mainly through promoting cytokine expression associated with innate immunity, such as IFN-γ. In addition, the pro-inflammatory cytokine TNF-α was also increased, while IL-6 level was decreased in serum. The titers of total antibodies against DENV2 in mice were also elevated. Administration of LE-PolyICLC not only alleviated the loss of body weight, degree of morbidity, and pathological damage in brains, but also reduced the viral titers and expression of viral E protein in the brain. Notably, the effectiveness of LE-PolyICLC was better than PolyICLC on the basis of the data presented in this study. These results, therefore, set a foundation for further development of LE-PolyICLC as an attractive candidate of antiviral agents to be used in both prophylactic and therapeutic settings in DENV diseases." @default.
• W2510108608 created "2016-09-16" @default.
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• W2510108608 date "2016-09-01" @default.
• W2510108608 modified "2023-09-26" @default.
• W2510108608 title "Antiviral effects of liposome-encapsulated PolyICLC against Dengue virus in a mouse model" @default.
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• W2510108608 doi "https://doi.org/10.1016/j.bbrc.2016.08.050" @default.
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