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- W2510112960 endingPage "434" @default.
- W2510112960 startingPage "409" @default.
- W2510112960 abstract "Cytoskeletal homeostasis is essential for the development, survival and maintenance of an efficient nervous system. Microtubules are highly dynamic polymers important for neuronal growth, morphology, migration and polarity. In cooperation with several classes of binding proteins, microtubules regulate long-distance intracellular cargo trafficking along axons and dendrites. The importance of a delicate interplay between cytoskeletal components is reflected in several human neurodegenerative disorders linked to abnormal microtubule dynamics, including Parkinson's disease (PD). Mounting evidence now suggests PD pathogenesis might be underlined by early cytoskeletal dysfunction. Advances in genetics have identified PD-associated mutations and variants in genes encoding various proteins affecting microtubule function including the microtubule-associated protein tau. In this review, we highlight the role of microtubules, their major posttranslational modifications and microtubule associated proteins in neuronal function. We then present key evidence on the contribution of microtubule dysfunction to PD. Finally, we discuss how regulation of microtubule dynamics with microtubule-targeting agents and deacetylase inhibitors represents a promising strategy for innovative therapeutic development." @default.
- W2510112960 created "2016-09-16" @default.
- W2510112960 creator A5013834527 @default.
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- W2510112960 creator A5021741148 @default.
- W2510112960 creator A5084264514 @default.
- W2510112960 creator A5091779727 @default.
- W2510112960 date "2016-09-06" @default.
- W2510112960 modified "2023-10-15" @default.
- W2510112960 title "Back to the tubule: microtubule dynamics in Parkinson’s disease" @default.
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