FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2510113510> ?p ?o ?g. }

• W2510113510 abstract "JST CREST, Osaka, Japan.Phosphatidylinositol(PtdIns)lipidshavebeenidentifiedaskeysignalingmedi-ators for random cell migration as well as chemoattractant-induced directionalmigration. However, how the PtdIns lipids are organized spatiotemporally toregulate cellular motility and polarity remains to be clarified. Here, we foundthat self-organized waves of PtdIns 3,4,5-trisphosphate [PtdIns(3,4,5)P3] aregenerated spontaneously on the membrane of Dictyostelium cells in theabsence of a chemoattractant. Characteristic oscillatory dynamics within thePtdIns lipids signaling system were determined experimentally by observingthe phenotypicvariability of PtdIns lipid waves in single cells, which exhibitedcharacteristics of a relaxation oscillator. The enzymes phosphatase and tensinhomolog (PTEN) and phosphoinositide-3-kinase (PI3K), which are regulatorsfor PtdIns lipid concentrations along the membrane, were essential for wavegeneration whereas functional actin cytoskeleton was not. Defects in these en-zymes inhibited wave generation as well as actin-based polarization and cellmigration. On the basis of these experimental results, we developed a reac-tion-diffusion model that reproduced the characteristic relaxation oscillationdynamics of the PtdIns lipid system, illustrating that a self-organizationmechanism providesthe basisfor thePtdInslipids signalingsystemto generatespontaneous spatiotemporal signals for random cell migration and thatmolecular noise derived from stochastic fluctuations within the signaling com-ponents gives rise to the variability of these spontaneous signals. PNAS 10712399-12404170-PlatThe Combination of Pulsatile and Switch-Like Behaviors of p53in Response to DNA DamageXiao-Peng Zhang, Feng Liu, Wei Wang.Nanjing University, Nanjing, China.Upon DNA damage, p53 is stabilized and activated to induce diverse cellularoutcomes including cell cycle arrest and apoptosis. The p53 dynamics can ex-hibit distinct modes, depending on cell and stress types. In an analog mode,high (low) levels of p53 lead to cell death (survival) in response to lethal (sub-lethal) DNA damage. By contrast, p53 levels exhibit a series of discrete pulsesinadigitalmode,whereinitisthenumberofp53pulsesthatdeterminesthecellfate [1]. Here, we explore whether both the modes of p53 are exploited in onecellular response. We propose a modular model for the cell fate decision be-tween survival and death, which is governed by the p53 network. At low dam-age levels, p53 levels exhibit few pulses, and the cell returns to normalproliferation after DNA damage is fixed. For irreparable damage, the amountof p53 first displays four pulses and then switches to high levels, and the cellundergoes apoptosis. The negative feedback loop between p53 and Mdm2and that between ATM and p53 via Wip1 are responsible for p53 oscillations,whereas the switching behavior occurs when the positive feedback loop be-tween p53 and PTEN predominates over the negative feedback loops. Sucha combination of pulsatile and switch-like behaviors of p53 may representaflexibleandreliablecontrolmode,avoidingunnecessarycelldeathorpromot-ing execution of apoptosis.This work also underscores that both the nature andstrength of feedback loops determine p53 dynamics.[1] X.-P. Zhang, F. Liu, Z. Cheng, and W. Wang (2009) Cell fate decision me-diated by p53 pulses. Proc. Natl. Acad. Sci. USA. 106, 12245-12250.171-PlatTime-Keeping in the Transcriptional Cascades of the DevelopingC. elegans EmbryoGautham Nair, Arjun Raj.University of Pennsylvania, Philadelphia, PA, USA.Cell differentiation and cell proliferation are coordinated during animal devel-opment by mechanisms that remain largely unknown. We use the fact that thetimespanofdevelopmentinC.eleganscanbevariedsignificantlybychangesintemperature andmutationstodiscernthenatureofthecoordinationmechanismat play in this organism. We have measured time profiles of gene expression inkey organogenesis pathways of C. elegans embryos that have grown underconditions and genetic backgrounds that significantly change the overall rateofdevelopment. We usedthesinglemoleculeRNAfluorescenceinsituhybrid-izationtechniquerecentlydevelopedbyourgrouptoobtainabsoluteRNAtran-scriptnumberswith singlemoleculesensitivity. Thedataallow usto determinetheextenttowhichRNAdynamicsremainlockedtothecellcycleaslifespanisvaried and infer the existence of coordinator processes from changes of appar-ent induction thresholds in transcriptional cascades." @default.
• W2510113510 created "2016-09-16" @default.
• W2510113510 creator A5010301182 @default.
• W2510113510 creator A5014879094 @default.
• W2510113510 creator A5015903700 @default.
• W2510113510 creator A5016744783 @default.
• W2510113510 creator A5019319065 @default.
• W2510113510 creator A5030553603 @default.
• W2510113510 creator A5033354384 @default.
• W2510113510 creator A5042911899 @default.
• W2510113510 creator A5046597133 @default.
• W2510113510 creator A5054885812 @default.
• W2510113510 creator A5060470951 @default.
• W2510113510 creator A5061780801 @default.
• W2510113510 creator A5080086756 @default.
• W2510113510 creator A5080542078 @default.
• W2510113510 creator A5089582273 @default.
• W2510113510 date "2011-01-01" @default.
• W2510113510 modified "2023-09-23" @default.
• W2510113510 title "PLATFORM O: Actin & Actin-binding Proteins" @default.
• W2510113510 cites W2068371312 @default.
• W2510113510 hasPublicationYear "2011" @default.
• W2510113510 type Work @default.
• W2510113510 sameAs 2510113510 @default.
• W2510113510 citedByCount "0" @default.
• W2510113510 crossrefType "journal-article" @default.
• W2510113510 hasAuthorship W2510113510A5010301182 @default.
• W2510113510 hasAuthorship W2510113510A5014879094 @default.
• W2510113510 hasAuthorship W2510113510A5015903700 @default.
• W2510113510 hasAuthorship W2510113510A5016744783 @default.
• W2510113510 hasAuthorship W2510113510A5019319065 @default.
• W2510113510 hasAuthorship W2510113510A5030553603 @default.
• W2510113510 hasAuthorship W2510113510A5033354384 @default.
• W2510113510 hasAuthorship W2510113510A5042911899 @default.
• W2510113510 hasAuthorship W2510113510A5046597133 @default.
• W2510113510 hasAuthorship W2510113510A5054885812 @default.
• W2510113510 hasAuthorship W2510113510A5060470951 @default.
• W2510113510 hasAuthorship W2510113510A5061780801 @default.
• W2510113510 hasAuthorship W2510113510A5080086756 @default.
• W2510113510 hasAuthorship W2510113510A5080542078 @default.
• W2510113510 hasAuthorship W2510113510A5089582273 @default.
• W2510113510 hasConcept C125705527 @default.
• W2510113510 hasConcept C142669718 @default.
• W2510113510 hasConcept C1491633281 @default.
• W2510113510 hasConcept C170493617 @default.
• W2510113510 hasConcept C185592680 @default.
• W2510113510 hasConcept C2780610907 @default.
• W2510113510 hasConcept C2993400109 @default.
• W2510113510 hasConcept C54166955 @default.
• W2510113510 hasConcept C55493867 @default.
• W2510113510 hasConcept C58207958 @default.
• W2510113510 hasConcept C62478195 @default.
• W2510113510 hasConcept C86803240 @default.
• W2510113510 hasConcept C95444343 @default.
• W2510113510 hasConceptScore W2510113510C125705527 @default.
• W2510113510 hasConceptScore W2510113510C142669718 @default.
• W2510113510 hasConceptScore W2510113510C1491633281 @default.
• W2510113510 hasConceptScore W2510113510C170493617 @default.
• W2510113510 hasConceptScore W2510113510C185592680 @default.
• W2510113510 hasConceptScore W2510113510C2780610907 @default.
• W2510113510 hasConceptScore W2510113510C2993400109 @default.
• W2510113510 hasConceptScore W2510113510C54166955 @default.
• W2510113510 hasConceptScore W2510113510C55493867 @default.
• W2510113510 hasConceptScore W2510113510C58207958 @default.
• W2510113510 hasConceptScore W2510113510C62478195 @default.
• W2510113510 hasConceptScore W2510113510C86803240 @default.
• W2510113510 hasConceptScore W2510113510C95444343 @default.
• W2510113510 hasLocation W25101135101 @default.
• W2510113510 hasOpenAccess W2510113510 @default.
• W2510113510 hasPrimaryLocation W25101135101 @default.
• W2510113510 hasRelatedWork W1514352851 @default.
• W2510113510 hasRelatedWork W1974640711 @default.
• W2510113510 hasRelatedWork W2016185141 @default.
• W2510113510 hasRelatedWork W2026972975 @default.
• W2510113510 hasRelatedWork W2038772694 @default.
• W2510113510 hasRelatedWork W2038957719 @default.
• W2510113510 hasRelatedWork W2040504910 @default.
• W2510113510 hasRelatedWork W2062489808 @default.
• W2510113510 hasRelatedWork W2076085879 @default.
• W2510113510 hasRelatedWork W2097711594 @default.
• W2510113510 hasRelatedWork W2108863061 @default.
• W2510113510 hasRelatedWork W2120665146 @default.
• W2510113510 hasRelatedWork W2145711932 @default.
• W2510113510 hasRelatedWork W2146749791 @default.
• W2510113510 hasRelatedWork W2167085867 @default.
• W2510113510 hasRelatedWork W2171520735 @default.
• W2510113510 hasRelatedWork W2531015943 @default.
• W2510113510 hasRelatedWork W2794584210 @default.
• W2510113510 hasRelatedWork W89528049 @default.
• W2510113510 hasRelatedWork W2798380729 @default.
• W2510113510 isParatext "false" @default.
• W2510113510 isRetracted "false" @default.
• W2510113510 magId "2510113510" @default.
• W2510113510 workType "article" @default.