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- W2510120973 endingPage "ftw087" @default.
- W2510120973 startingPage "ftw087" @default.
- W2510120973 abstract "The significant and sometimes dramatic rise in the number of circulating white blood cells (leukocytosis) in infants suffering from pertussis (whooping cough) has been recognized for over a century. Although pertussis is a disease that afflicts people of all ages, it can be particularly severe in young infants, and these are the individuals in whom leukocytosis is most pronounced. Very high levels of leukocytosis are associated with poor outcome in infants hospitalized with pertussis and modern treatments are often aimed at reducing the number of leukocytes. Pertussis leukocytosis is caused by pertussis toxin, a soluble protein toxin released by Bordetella pertussis during infection, but the exact mechanisms by which this occurs are still unclear. In this minireview, I discuss the history of clinical and experimental findings on pertussis leukocytosis, possible contributing mechanisms causing this condition and treatments aimed at reducing leukocytosis in hospitalized infants. Since recent studies have detailed significant associations between specific levels of pertussis leukocytosis and fatal outcome, this is a timely review that may stimulate new thinking on how to understand and combat this problem." @default.
- W2510120973 created "2016-09-16" @default.
- W2510120973 creator A5077507710 @default.
- W2510120973 date "2016-09-07" @default.
- W2510120973 modified "2023-10-12" @default.
- W2510120973 title "Pertussis leukocytosis: mechanisms, clinical relevance and treatment" @default.
- W2510120973 cites W1496654715 @default.
- W2510120973 cites W1501500713 @default.
- W2510120973 cites W1574141134 @default.
- W2510120973 cites W1609183689 @default.
- W2510120973 cites W1774826011 @default.
- W2510120973 cites W18518520 @default.
- W2510120973 cites W1861980580 @default.
- W2510120973 cites W1909245876 @default.
- W2510120973 cites W1929164122 @default.
- W2510120973 cites W1965207731 @default.
- W2510120973 cites W1968855909 @default.
- W2510120973 cites W1975998142 @default.
- W2510120973 cites W1993717811 @default.
- W2510120973 cites W1996437233 @default.
- W2510120973 cites W1998125315 @default.
- W2510120973 cites W2006073149 @default.
- W2510120973 cites W2007963315 @default.
- W2510120973 cites W2009110076 @default.
- W2510120973 cites W2010947597 @default.
- W2510120973 cites W2013685153 @default.
- W2510120973 cites W2014542562 @default.
- W2510120973 cites W2020147333 @default.
- W2510120973 cites W2029806708 @default.
- W2510120973 cites W2031828123 @default.
- W2510120973 cites W2036163111 @default.
- W2510120973 cites W2037575016 @default.
- W2510120973 cites W2038805001 @default.
- W2510120973 cites W2039017009 @default.
- W2510120973 cites W2039353277 @default.
- W2510120973 cites W2040668154 @default.
- W2510120973 cites W2042706137 @default.
- W2510120973 cites W2044845515 @default.
- W2510120973 cites W2045089341 @default.
- W2510120973 cites W2047143316 @default.
- W2510120973 cites W2048709572 @default.
- W2510120973 cites W2052446038 @default.
- W2510120973 cites W2055254020 @default.
- W2510120973 cites W2056105759 @default.
- W2510120973 cites W2058582950 @default.
- W2510120973 cites W2058764271 @default.
- W2510120973 cites W2068404443 @default.
- W2510120973 cites W2070776631 @default.
- W2510120973 cites W2071783964 @default.
- W2510120973 cites W2072130538 @default.
- W2510120973 cites W2079776816 @default.
- W2510120973 cites W2082211297 @default.
- W2510120973 cites W2088563557 @default.
- W2510120973 cites W2088616018 @default.
- W2510120973 cites W2090153931 @default.
- W2510120973 cites W2097158912 @default.
- W2510120973 cites W2101693605 @default.
- W2510120973 cites W2102635010 @default.
- W2510120973 cites W2103719474 @default.
- W2510120973 cites W2103916556 @default.
- W2510120973 cites W2108152721 @default.
- W2510120973 cites W2108332676 @default.
- W2510120973 cites W2112015729 @default.
- W2510120973 cites W2115725634 @default.
- W2510120973 cites W2116714376 @default.
- W2510120973 cites W2119341573 @default.
- W2510120973 cites W2121777722 @default.
- W2510120973 cites W2130266290 @default.
- W2510120973 cites W2131337790 @default.
- W2510120973 cites W2132617216 @default.
- W2510120973 cites W2134076454 @default.
- W2510120973 cites W2136059362 @default.
- W2510120973 cites W2136732064 @default.
- W2510120973 cites W2137536511 @default.
- W2510120973 cites W2138762139 @default.
- W2510120973 cites W2151648957 @default.
- W2510120973 cites W2151795054 @default.
- W2510120973 cites W2153531439 @default.
- W2510120973 cites W2161597539 @default.
- W2510120973 cites W2162511842 @default.
- W2510120973 cites W2165439949 @default.
- W2510120973 cites W2165705942 @default.
- W2510120973 cites W2171944073 @default.
- W2510120973 cites W2186662694 @default.
- W2510120973 cites W2210945128 @default.
- W2510120973 cites W2260627845 @default.
- W2510120973 cites W2323218080 @default.
- W2510120973 cites W2327155560 @default.
- W2510120973 cites W2398077174 @default.
- W2510120973 cites W2399896610 @default.
- W2510120973 cites W2410052886 @default.
- W2510120973 cites W2412974022 @default.
- W2510120973 cites W3145573608 @default.
- W2510120973 cites W4233569868 @default.
- W2510120973 cites W4248400410 @default.
- W2510120973 cites W648593305 @default.
- W2510120973 doi "https://doi.org/10.1093/femspd/ftw087" @default.
- W2510120973 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5761200" @default.