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• W2510135237 abstract "A major consideration in assisted reproduction is providing a laboratory environment that is as similar to in vivo conditions as possible during embryo development. In vivo, the embryo is constantly in motion due to gross movement of the carrier or more localized forces from tubal fluid flow and kinetic forces exuded by tubal cilia. Laboratories worldwide currently use static culture systems; however, a dynamic system may more closely mimic in vivo conditions. Reported benefits to dynamic culture include improved blastulation and pregnancy rates (1,2). This study seeks to determine if dynamic embryo culture impacts the reproductive potential of human embryos resulting from IVF. Paired randomized control trial. IVF patients with normal ovarian reserve have been recruited for participation at a single center since 2015. IVF care is routine until fertilization is confirmed. 2-pronuclei (2PN) are then randomized, and half of each patient’s 2PN are cultured in static culture and half in dynamic culture. Preimplantation genetic screening (PGS) is being utilized to control for aneuploidy and allow for DNA-fingerprinting. The best euploid blastocyst from each culture system is selected and patients will undergo a frozen 2-embryo transfer. If a singleton gestation results, DNA-fingerprinting can determine which of the two blastocysts implanted. The dynamic platform being utilized is the NSSB-300 (Nepagene, Ichikawa, Japan). Outcomes including usable blastulation rate and pregnancy outcomes are being analyzed in a paired fashion. A usable blastocyst is suitable for transfer or vitrification for future use. This analysis was performed using a wilcoxon signed-rank test. To date, 55 patients have enrolled. 51 patients have completed vaginal oocyte retrieval and blastocyst vitrification for future transfer. The mean age of patients is 34.8 + 3.7 years. The mean day 3 follicle stimulating hormone level is 6.18+ 2.20 IU/mL, and the median anti-mullerian hormone level is 3.71 ng/mL (range 1.27-27.36 ng/mL) in this cohort. The mean number of metaphase II oocytes retrieved was 15.4 + 8.5 oocytes and the average rate of fertilization was normal (85.7%). 335 static 2PN and 331 dynamic 2PN were followed. 178 blastocysts developed in static culture and 154 blastocysts developed in dynamic culture. In the paired analysis, the rate of usable blastulation was not different between static culture (53.7%) and dynamic culture (52.8%), (p=0.20). After PGS, there was also no difference in the rate of euploidy between static culture (66.7%) and dynamic culture (66.7%), (p=0.46). In this interim analysis, dynamic culture did not improve blastulation rate which is contrary to previously published data. Further investigation including a paired comparison of the sustained implantation rate between static and dynamic culture systems is needed." @default.
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• W2510135237 date "2016-09-01" @default.
• W2510135237 modified "2023-10-14" @default.
• W2510135237 title "EnMotion: Embryo’s Natural Motion. blastulation is not different between static and dynamic culture systems" @default.
• W2510135237 doi "https://doi.org/10.1016/j.fertnstert.2016.07.1018" @default.
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