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• W2510144620 abstract "ObjectiveTo investigate the differences in euploidy rates between PGS techniques in patients undergoing blastomere vs trophectoderm biopsy.DesignRetrospective cohort study.Materials and MethodsData used in this study were collected from our routine PGS patients who used either autologous and or donor oocytes from 2014 to 2016 for incubation following insemination (n=365). Translocation and PGD cycles were excluded. The resulting embryos were divided into four groups based on biopsy day (blastomere versus trophoectoderm) and PGS technique used (comparative genomic hybridization microarray [aCGH] vs Next Generation Sequencing [NGS]) (n=2010): Group 1 (aCGH blastomere, n=873), Group 2 (aCGH trophectoderm, n=239), Group 3 (NGS blastomere, n=21) and Group 4 (NGS trophectoderm, n=877). The use of oocyte donor was similar between groups. Patients’ ages were ranged as following; Group 1 (20-48), Group 2 (25-46), Group 3 (27-36) and Group 4 (23-47). Euploidy rates were analysed using chi square test among the groups.ResultsAccording to our findings, euploidy rates (n) were found to be 22.1% (193) and 32.6% (78) (p< .001) within Group 1 vs Group 2, respectively. Likewise, the euploidy rates were different in Group 3 as 23.8% (5) and Group 4 as 47% (412), respectively (p< .035). The euploidy rate in Group 4 was higher than that in Group 2 (p<.00001). The results were shown as a table below. There was no difference between Group 1 vs Group 3 (p>.05).ConclusionsTabled 1Euploidy Rates of Embryos within GroupsGroup 1Group 2Group 3Group 422.1%32.6%23.8%47% Open table in a new tab ObjectiveTo investigate the differences in euploidy rates between PGS techniques in patients undergoing blastomere vs trophectoderm biopsy. To investigate the differences in euploidy rates between PGS techniques in patients undergoing blastomere vs trophectoderm biopsy. DesignRetrospective cohort study. Retrospective cohort study. Materials and MethodsData used in this study were collected from our routine PGS patients who used either autologous and or donor oocytes from 2014 to 2016 for incubation following insemination (n=365). Translocation and PGD cycles were excluded. The resulting embryos were divided into four groups based on biopsy day (blastomere versus trophoectoderm) and PGS technique used (comparative genomic hybridization microarray [aCGH] vs Next Generation Sequencing [NGS]) (n=2010): Group 1 (aCGH blastomere, n=873), Group 2 (aCGH trophectoderm, n=239), Group 3 (NGS blastomere, n=21) and Group 4 (NGS trophectoderm, n=877). The use of oocyte donor was similar between groups. Patients’ ages were ranged as following; Group 1 (20-48), Group 2 (25-46), Group 3 (27-36) and Group 4 (23-47). Euploidy rates were analysed using chi square test among the groups. Data used in this study were collected from our routine PGS patients who used either autologous and or donor oocytes from 2014 to 2016 for incubation following insemination (n=365). Translocation and PGD cycles were excluded. The resulting embryos were divided into four groups based on biopsy day (blastomere versus trophoectoderm) and PGS technique used (comparative genomic hybridization microarray [aCGH] vs Next Generation Sequencing [NGS]) (n=2010): Group 1 (aCGH blastomere, n=873), Group 2 (aCGH trophectoderm, n=239), Group 3 (NGS blastomere, n=21) and Group 4 (NGS trophectoderm, n=877). The use of oocyte donor was similar between groups. Patients’ ages were ranged as following; Group 1 (20-48), Group 2 (25-46), Group 3 (27-36) and Group 4 (23-47). Euploidy rates were analysed using chi square test among the groups. ResultsAccording to our findings, euploidy rates (n) were found to be 22.1% (193) and 32.6% (78) (p< .001) within Group 1 vs Group 2, respectively. Likewise, the euploidy rates were different in Group 3 as 23.8% (5) and Group 4 as 47% (412), respectively (p< .035). The euploidy rate in Group 4 was higher than that in Group 2 (p<.00001). The results were shown as a table below. There was no difference between Group 1 vs Group 3 (p>.05). According to our findings, euploidy rates (n) were found to be 22.1% (193) and 32.6% (78) (p< .001) within Group 1 vs Group 2, respectively. Likewise, the euploidy rates were different in Group 3 as 23.8% (5) and Group 4 as 47% (412), respectively (p< .035). The euploidy rate in Group 4 was higher than that in Group 2 (p<.00001). The results were shown as a table below. There was no difference between Group 1 vs Group 3 (p>.05). ConclusionsTabled 1Euploidy Rates of Embryos within GroupsGroup 1Group 2Group 3Group 422.1%32.6%23.8%47% Open table in a new tab" @default.
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• W2510144620 date "2016-09-01" @default.
• W2510144620 modified "2023-10-16" @default.
• W2510144620 title "Improving euploidy rates in patients undergoing preimplantation genetic screening (PGS)" @default.
• W2510144620 doi "https://doi.org/10.1016/j.fertnstert.2016.07.453" @default.
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