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- W2510158334 endingPage "160091" @default.
- W2510158334 startingPage "160091" @default.
- W2510158334 abstract "Axon injury in the peripheral nervous system (PNS) induces a regeneration-associated gene (RAG) response. Atf3 (activating transcription factor 3) is such a RAG and ATF3's transcriptional activity might induce ‘effector’ RAGs (e.g. small proline rich protein 1a ( Sprr1a ) , Galanin ( Gal ) , growth-associated protein 43 ( Gap43 )) facilitating peripheral axon regeneration. We provide a first analysis of Atf3 mouse mutants in peripheral nerve regeneration. In Atf3 mutant mice, facial nerve regeneration and neurite outgrowth of adult ATF3-deficient primary dorsal root ganglia neurons was decreased. Using genome-wide transcriptomics, we identified a neuropeptide-encoding RAG cluster (vasoactive intestinal peptide ( Vip ) , Ngf, Grp, Gal, Pacap ) regulated by ATF3. Exogenous administration of neuropeptides enhanced neurite growth of Atf3 mutant mice suggesting that these molecules might be effector RAGs of ATF3's pro-regenerative function. In addition to the induction of growth-promoting molecules, we present data that ATF3 suppresses growth-inhibiting molecules such as chemokine (C-C motif) ligand 2. In summary, we show a pro-regenerative ATF3 function during PNS nerve regeneration involving transcriptional activation of a neuropeptide-encoding RAG cluster. ATF3 is a general injury-inducible factor, therefore ATF3-mediated mechanisms identified herein might apply to other cell and injury types." @default.
- W2510158334 created "2016-09-16" @default.
- W2510158334 creator A5026785770 @default.
- W2510158334 creator A5032123513 @default.
- W2510158334 creator A5065262725 @default.
- W2510158334 creator A5067525886 @default.
- W2510158334 creator A5071840072 @default.
- W2510158334 creator A5088925456 @default.
- W2510158334 date "2016-08-01" @default.
- W2510158334 modified "2023-10-12" @default.
- W2510158334 title "<i>Atf3</i> mutant mice show reduced axon regeneration and impaired regeneration-associated gene induction after peripheral nerve injury" @default.
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- W2510158334 doi "https://doi.org/10.1098/rsob.160091" @default.