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- W2510160646 endingPage "648" @default.
- W2510160646 startingPage "640" @default.
- W2510160646 abstract "There is growing interest in the use of oxytocin (OT) as a potential treatment for alcohol and other substance-use disorders. OT is a neuropeptide that modulates adaptive processes associated with addiction including reward, tolerance, associative learning, memory, and stress responses. OT exerts its effects through interactions with the hypothalamic–pituitary–adrenal axis and multiple neurotransmitter systems including the dopamine mesolimbic reward and corticotrophin-releasing factor stress systems. The effects of OT on stress systems are of high interest, given the strong link between stress, drug use and relapse, and known dysregulation of hypothalamic–pituitary–adrenal-axis activity associated with substance-use disorders. At the same time, the OT system is itself altered by acute or chronic drug exposure. This review summarizes the preclinical and clinical literature on the OT system and its relevance to drug and alcohol addiction. In addition, findings from recent clinical trials conducted in participants with cocaine, cannabis, or alcohol use disorder are included and evidence that OT may help to normalize blunted stress responses, and attenuate withdrawal-associated hypercortisolism, negative mood, and withdrawal symptoms is summarized." @default.
- W2510160646 created "2016-09-16" @default.
- W2510160646 creator A5040605784 @default.
- W2510160646 creator A5078088256 @default.
- W2510160646 date "2016-12-01" @default.
- W2510160646 modified "2023-10-01" @default.
- W2510160646 title "Oxytocin for the treatment of drug and alcohol use disorders" @default.
- W2510160646 cites W1550059138 @default.
- W2510160646 cites W1556392272 @default.
- W2510160646 cites W1570177053 @default.
- W2510160646 cites W1595671608 @default.
- W2510160646 cites W1627848973 @default.
- W2510160646 cites W1744359224 @default.
- W2510160646 cites W1750764127 @default.
- W2510160646 cites W1760946711 @default.
- W2510160646 cites W1828556423 @default.
- W2510160646 cites W1887281586 @default.
- W2510160646 cites W1898877040 @default.
- W2510160646 cites W1902931910 @default.
- W2510160646 cites W1924375074 @default.
- W2510160646 cites W1932902309 @default.
- W2510160646 cites W1968246625 @default.
- W2510160646 cites W1968553080 @default.
- W2510160646 cites W1970577797 @default.
- W2510160646 cites W1971319935 @default.
- W2510160646 cites W1971804394 @default.
- W2510160646 cites W1972393301 @default.
- W2510160646 cites W1974375338 @default.
- W2510160646 cites W1977190194 @default.
- W2510160646 cites W1977529793 @default.
- W2510160646 cites W1978134963 @default.
- W2510160646 cites W1981032504 @default.
- W2510160646 cites W1985605151 @default.
- W2510160646 cites W1985852293 @default.
- W2510160646 cites W1989197363 @default.
- W2510160646 cites W1990623083 @default.
- W2510160646 cites W1991163868 @default.
- W2510160646 cites W1993306413 @default.
- W2510160646 cites W1999948756 @default.
- W2510160646 cites W2000714241 @default.
- W2510160646 cites W2001217292 @default.
- W2510160646 cites W2003149273 @default.
- W2510160646 cites W2003308034 @default.
- W2510160646 cites W2004882698 @default.
- W2510160646 cites W2012409109 @default.
- W2510160646 cites W2014187448 @default.
- W2510160646 cites W2015332984 @default.
- W2510160646 cites W2016825278 @default.
- W2510160646 cites W2017323063 @default.
- W2510160646 cites W2017342751 @default.
- W2510160646 cites W2021782736 @default.
- W2510160646 cites W2023279242 @default.
- W2510160646 cites W2023636464 @default.
- W2510160646 cites W2027658514 @default.
- W2510160646 cites W2028244020 @default.
- W2510160646 cites W2029951737 @default.
- W2510160646 cites W2031414364 @default.
- W2510160646 cites W2031660167 @default.
- W2510160646 cites W2034728900 @default.
- W2510160646 cites W2035096213 @default.
- W2510160646 cites W2036441276 @default.
- W2510160646 cites W2037364012 @default.
- W2510160646 cites W2043559838 @default.
- W2510160646 cites W2043628043 @default.
- W2510160646 cites W2043676928 @default.
- W2510160646 cites W2044547549 @default.
- W2510160646 cites W2048162947 @default.
- W2510160646 cites W2050416351 @default.
- W2510160646 cites W2050835897 @default.
- W2510160646 cites W2051346624 @default.
- W2510160646 cites W2055080711 @default.
- W2510160646 cites W2057967199 @default.
- W2510160646 cites W2059330727 @default.
- W2510160646 cites W2059337320 @default.
- W2510160646 cites W2059343429 @default.
- W2510160646 cites W2060157424 @default.
- W2510160646 cites W2060752188 @default.
- W2510160646 cites W2061226698 @default.
- W2510160646 cites W2062333750 @default.
- W2510160646 cites W2064832639 @default.
- W2510160646 cites W2065577847 @default.
- W2510160646 cites W2067577447 @default.
- W2510160646 cites W2069219662 @default.
- W2510160646 cites W2072568231 @default.
- W2510160646 cites W2073015613 @default.
- W2510160646 cites W2074431470 @default.
- W2510160646 cites W2076518235 @default.
- W2510160646 cites W2077382941 @default.
- W2510160646 cites W2084236418 @default.
- W2510160646 cites W2085062396 @default.
- W2510160646 cites W2086190854 @default.
- W2510160646 cites W2086264205 @default.
- W2510160646 cites W2087433398 @default.
- W2510160646 cites W2089957777 @default.
- W2510160646 cites W2090086966 @default.
- W2510160646 cites W2090312166 @default.
- W2510160646 cites W2090689542 @default.
- W2510160646 cites W2091036510 @default.